副教授 |生命科学学院, 基础免疫与微生物学系

周稳博士于2017年在中国科学院植物研究所获得理学博士学位。作为Benacerraf Postdoctoral Fellow in Immunology和Charles A. King Trust Postdoctoral Fellow,周稳博士于2017年至2021年期间在美国哈佛大学医学院/丹娜法伯癌症研究所从事博士后研究工作。周稳博士致力于研究天然免疫系统对于核酸的免疫应答机制,博后期间以cGAS-STING信号为例,系统的研究了抗病原微生物和抗肿瘤免疫。研究结果为深入理解健康和疾病状态下免疫细胞如何感知和响应胞质DNA提供了思路。

周稳博士于2021年4月加入南方科技大学,任课题组组长、博导。实验室将研究免疫细胞中生物大分子凝聚体在响应病原微生物、胁迫和癌症的免疫信号中的重要作用。同时,实验室将致力于发现新的参与核酸免疫的受体和重要调控因子。

个人简介

研究领域

我们致力于抗病原微生物和抗肿瘤免疫应答机制的研究。利用生物化学、细胞生物学和结构生物学的手段,我们将围绕以下科学问题展开研究:(1)免疫细胞如何实现精确的免疫监控与调节?(2)是否存在未知的免疫信号通路?围绕这些问题,我们的研究方向包括:

1. 相分离现象调控免疫信号:相分离是指生物大分子之间由于弱相互作用聚集在一起形成独立液滴的现象,其在天然免疫信号通路中的作用还很不清楚。我们将系统研究相关免疫蛋白相分离发生的分子基础以及相分离在调控天然免疫信号中的生物学功能。

2. 发现新的参与核酸免疫应答的受体和调控蛋白:核酸(包括DNA和RNA)在激活免疫系统中发挥了重要作用,它们能够作为危险信号分子直接触发快速的免疫应答。其中,核酸受体是感受异常核酸存在并引起免疫应答的关键分子。生物信息学分析暗示动物中存在大量未被鉴定的潜在核酸受体蛋白。我们将筛选并鉴定新的核酸受体和相关调控因子,并研究其激活的分子机理与调控网络。


教学

《免疫学》、《表观遗传学》


学术成果 查看更多

Pubmed (Link)

Google Scholar (Link)

 

2024

Biomolecular condensates and disease pathogenesis.

Ruan K#, Bai G#, Fang Y#, Li D#, Li T#, Liu X#, Lu B#, Lu Q#, Songyang Z#, Sun S#, Wang Z#, Zhang X#, Zhou W#, Zhang H#.

Science China Life Sciences. 2024. Advanced Online Publication. (# co-corresponding)

Phase separation as a new form of regulation in innate immunity.

Wang L, Zhou W.

Molecular Cell. 2024; 84, 2410–2422. PMID 38936362.

Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling.

Shim A, Luan X, Zhou W, Crow Y, Maciejowski J.

Human Molecular Genetics. 2024; 25, ddae089. PMID 38796715.

Innate immune responses to RNA: sensing and signaling.

Luan X*, Wang L*, Song G, Zhou W.

Frontiers in Immunology. 2024; 15,e1287940. PMID 38343534. (* co-first)

 

2023

Membrane-less organelles: Condensation matters.

Ruan K#, Lin Y#, Yang P#, Zhou W#.

Nature Chemical Biology. 2023.  PMID 37731018. (# co-corresponding)

Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases.

Mosallanejad K, Kennedy SN, Bahleda KM, Slavik KM, Zhou W, Govande AA, Hancks DC, Kranzusch PJ, Kagan JC.

Science Immunology. 2023; 8(79), eabp9765. PMID 36662885.

 

2022

A microbial transporter of the dietary antioxidant ergothioneine.

Dumitrescu DG, Gordon EM, Kovalyova Y, Seminara AB, Duncan-Lowey B, Forster ER, Zhou W, Booth CJ, Shen A, Kranzusch PJ, Hatzios SK.

Cell. 2022; 185(24), 4526–4540.e18. PMID: 36347253.

Introducing new group leaders: Wen Zhou.

Molecular Cell. 2022; 82(18), 3313–3314. PMID: 36113409

Structural basis of human TREX1 DNA degradation and autoimmune disease.

Zhou W#, Richmond-Buccola D, Wang Q, Kranzusch PJ#.

Nature Communications. 2022; 13(1), 4277. PMID 35879334. (# co-corresponding)

Varicella-Zoster Virus ORF9 Is an Antagonist of the DNA Sensor cGAS.

Hertzog J, Zhou W, Rigby RE, Fowler G, Rigby RE, Bridgeman A, Blest HT, Cursi C, Chauveau L, Davenne T, Warner BE, Kranzusch PJ, Rehwinkel J.

EMBO. 2022; 41(14), e109217. PMID: 35670106.

 

2021

CAF Proteins Help SOT1 Regulate the Stability of Chloroplast ndhA Transcripts.

Li X, Luo W, Zhou W, Yin X, Wang X, Li X, Jiang C, Zhang Q, Kang X, Zhang A, Zhang Y, Lu C.

International Journal of Molecular Sciences. 2021; 22, e12639. PMID: 34884441.

cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila.

Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Leler JL, Kranzusch PJ.

Nature. 2021; 597(7874), 109–113. PMID 34261127.

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.

Zhou W, Mohr L, Maciejowski J, Kranzusch PJ.

Molecular Cell. 2021; 81(4): 739–755. PMID: 33606975.

 

————Start of lab at SUSTech in 2021————

 

2020

Pentatricopeptide repeat protein PHOTOSYSTEM I BIOGENESIS FACTOR2 is required for splicing of ycf3.

Wang X, Yang Z, Zhang Y, Zhou W, Zhang A, Lu C.

Journal of Integrative Plant Biology. 2020; 11(62), 1741–1761. PMID: 32250043.

 

2019

Analysis of human cGAS activity and structure.

Zhou W, Whiteley AT, Kranzusch PJ.

Methods in Enzymology. 2019; 625, 13–40. PMID: 31455523.

PPR protein BFA2 is essential for the accumulation of the atpH/F transcript in chloroplasts.

Zhang L, Zhou W, Che L, Rochaix JD, Lu C, Li W, Peng L.

Frontiers in Plant Science. 2019; 10, 446. PMID: 31031784.

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.

Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC.

Cell. 2019; 176(6), 1432–1446.e11. PMID: 30827685.

 

2018

Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance.

Zhou W*, Whiteley AT*, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ.

Cell. 2018; 174(2), 300–311. PMID: 30007416. (* co-first authors)

 

2017

PPR-SMR protein SOT1 has RNA endonuclease activity.

Zhou W*, Lu Q*, Li Q, Wang L, Ding S, Zhang A, Wen X, Zhang L, Lu C.

PNAS. 2017; 114(8), E1554–E1563. PMID: 28167782. (* co-first authors)

The phytol phosphorylation pathway is essential for the biosynthesis of phylloquinone, which is required for photosystem I stability in Arabidopsis.

Wang L, Li Q, Zhang A, Zhou W, Jiang R, Yang Z, Yang H, Qin X, Ding S, Lu Q, Wen X, Lu C.

Molecular Plant. 2017; 10(1): 183–196. PMID: 28007557.

 

2013

Chloroplast small heat shock protein HSP21 interacts with plastid nucleoid protein pTAC5 and is essential for chloroplast development in Arabidopsis under heat stress.

Zhong L, Zhou W, Wang H, Ding S, Lu Q, Wen X, Peng L, Zhang L, Lu C.

Plant Cell. 2013; 25(8), 2925–2943. PMID: 23922206.

新闻动态 更多新闻

  • [2024.6.27] Molecular Cell | Phase separation as a new form of regulation in innate immunity

    2024-06-27
  • [2024.1.25] Frontiers in Immunology | Innate immune responses to RNA: sensing and signaling

    2024-01-25
  • [2023.9.20] Nature Chemical Biology | Membrane-less organelles: Condensation matters

    2024-01-25

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