Assistant Professor Department of Biology
Dr. Hanbing Zhong got his PhD degree from Peking University in 2007, and worked for UCLA as postdoctor from 2007 to 20018. From 2008 to 2015, Dr. Zhong worked for Peking University as Associate Professor. In 2013, Dr. Zhong joined SUSTech. The lab of Dr. Zhong uses zebrafish as model organism to investigate endodermal organogenesis, hematopoiesis, drug discovery and neurodegenerative diseases modeling.
Personal Profile
Profile
Dr. Hanbing Zhong got his PhD degree from Peking University in 2007 and worked for UCLA as postdoctor. In 2013, Dr. Zhong joined SUSTech and worked as Assistant Professor.
Research interests:
Drug discovery, Chemical genetics, Developmental biology, Reverse genetics, Neuroscience, Disease model
Work background
2013 –， SUSTech，Assistant Professor
2008 – 2013，Peking University Shenzhen Graduate School, Associate Professor
2007 – 2008，UCLA，Postdoctor
Education background
2000 - 2007, Peking University, Cell Biology, PhD
1995 - 1999, Ocean University of China, marine biology, Bachelor
Selected paper
◆ Ren, G., Li, S., Zhong, H., and Lin, S. (2013) Zebrafish tyrosine hydroxylase 2 gene encodes tryptophan hydroxylase. The Journal of biological chemistry 288, 22451-22459
◆ Chen, L., Ren, X., Liang, F., Li, S., Zhong, H., and Lin, S. (2012) Characterization of two novel small molecules targeting melanocyte development in zebrafish embryogenesis. Pigment cell & melanoma research 25, 446-453
◆ Zhong, H., Wang, D., Wang, N., Rios, Y., Huang, H., Li, S., Wu, X., and Lin, S. (2011) Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity. Cell research 21, 1080-1087
◆ Zhong, H., Zou, H., Semenov, M. V., Moshinsky, D., He, X., Huang, H., Li, S., Quan, J., Yang, Z., and Lin, S. (2009) Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling. Molecular bioSystems 5, 1356-1360
◆ Zhong, H., Wu, X., Huang, H., Fan, Q., Zhu, Z., and Lin, S. (2006) Vertebrate MAX-1 is required for vascular patterning in zebrafish. Proceedings of the National Academy of Sciences of the United States of America 103, 16800-16805
Research
We use zebrafish to investigate the molecular mechanisms by which the biological processes are controlled in embryogenesis and model diseases. Currently, we are particularly interested in three areas, endoderm organ development, hematopoiesis, and Parkinson’s disease model.
Publications Read More
1. Xue, G., Wang, K., Zhou, D., Zhong, H., and Pan, Z. (2019) Light-Induced Protein Degradation with Photocaged PROTACs. J Am Chem Soc
2. Yuan, B., Wang, X., Fan, C., You, J., Liu, Y., Weber, J. D., Zhong, H., and Zhang, Y. (2016) DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle. Molecular and cellular biology 36, 2903-2917
3. Ren, G., Li, S., Zhong, H., and Lin, S. (2013) Zebrafish tyrosine hydroxylase 2 gene encodes tryptophan hydroxylase. The Journal of biological chemistry 288, 22451-22459
4. Zhong, H., Wang, D., Wang, N., Rios, Y., Huang, H., Li, S., Wu, X., and Lin, S. (2011) Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity. Cell research 21, 1080-1087
5. Ren, G., Xin, S., Li, S., Zhong, H., and Lin, S. (2011) Disruption of LRRK2 does not cause specific loss of dopaminergic neurons in zebrafish. PloS one 6, e20630
6. Zou, H. X., Zhou, L. Y., Li, Y. Z., Cui, Y., Zhong, H. B., Pan, Z. Y., Yang, Z., and Quan, J. M. (2010) Benzo[e]isoindole-1,3-diones as Potential Inhibitors of Glycogen Synthase Kinase-3 (GSK-3). Synthesis, Kinase Inhibitory Activity, Zebrafish Phenotype, and Modeling of Binding Mode. Journal of Medicinal Chemistry 53, 994-1003
7. Zhong, H., Wu, X., Huang, H., Fan, Q., Zhu, Z., and Lin, S. (2006) Vertebrate MAX-1 is required for vascular patterning in zebrafish. Proceedings of the National Academy of Sciences of the United States of America 103, 16800-16805
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Contact Us
Contact Address
Research Building 1, Office 208 & Lab 214 No 1088,xueyuan Rode Nanshan District, Shenzhen, Guangdong, China
Office Phone
0755-88018417
zhonghb@sustc.edu.cn