Assistant Professor Department of Biology   Research Group

Dr. Meizhen Zheng obtained her Ph.D. degree from Sun Yat-Sen University Cancer Center in 2007. Then she achieved well-training in 3D genome mapping technology at Genome Institute of Singapore (GIS) and The Jackson Laboratory for Genomic Medicine (JGM) respectively since 2010. Dr. Zheng joined Southern University of Science and Technology (SUSTech) as an Assistant Professor in 2019 and focusing on the development of 3D genome mapping technology with single-molecule precision in single nuclei.

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Research

◆ Multiplex chromatin interaction analysis with single-molecule precision in single nuclei.

◆ Genome-wide protein factor mediated RNA-chromatin DNA interaction analysis.

◆ The interested RNA mediated 3D genome architecture and the transcription regulation mechanism.


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◆ First author research papers:

Meizhen Zheng, Simon Zhongyuan Tian, Daniel Capurso, Minji Kim, Rahul Maurya, Byoungkoo Lee, Emaly Piecuch, Liang Gong, Jacqueline Jufen Zhu, Zhihui Li, Chee Hong Wong, Chew Yee Ngan, Ping Wang, Xiaoan Ruan, Chia-Lin Wei & Yijun Ruan. Multiplex Chromatin Interaction Analysis with Single-Molecule Precision. Nature. 2019, 556:558-562.

M.Z. Zheng, L.M. Zheng and Y.X. Zeng. SCC-112 gene is involved in tumor progression and promotes the cell proliferation in G2/M phase. J Cancer Res Clin Oncol. 2008 Apr; 134(4): 453-62.

Meizhen Zheng, Haide Qin, Ruhua Zhang, Xingjuan Yu, Lizhen Chen, Qisheng Feng, Yixin Zeng. Haplotype of gene Nedd4 binding protein 2 associated with sporadic Nasopharyngeal carcinoma in the Southern Chinese population. J Transl Med. 2007 Jul 13; 5:36.

Zheng, MZ; Jiang, JW. Progress in unmethylated immunostimulatory oligodeoxynucletides. Progress In Biochemistry And Biophysics. 2003,30(2):190-193.

◆ Co-author research papers:

The 4D nucleome project. The 4D Nucleome Network, Nature. 2017 Sep 13; 549(7671): 219–226.

Xingwang Li,Oscar Junhong Luo,Ping Wang, Meizhen Zheng, Danjuan Wang, Emaly Piecuch, Jacqueline Jufen Zhu,Simon Zhongyuan Tian,Zhonghui Tang,Guoliang Li & Yijun Ruan. Long-read ChIA-PET for base-pair-resolution mapping of haplotype-specific chromatin interactions. Nature Protocol. 2017,12:899-915.

Zhonghui Tang, Oscar Junhong Luo, Xingwang Li, Meizhen Zheng, Jacqueline Jufen Zhu, Przemyslaw Szalaj, Pawel Trzaskoma, Adriana Magalska, Jakub Wlodarczyk, Blazej Ruszczycki, Paul Michalski, Emaly Piecuch, Ping Wang, Danjuan Wang, Simon Zhongyuan Tian, May Penrad-Mobayed, Laurent M Sachs, Xiaoan Ruan, Chia-Lin Wei, Edison T Liu, Grzegorz M Wilczynski, Dariusz Plewczynski, Guoliang Li, Yijun Ruan. CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription. Cell.2015, 163:1611-1627.

Guoliang Li, X. Ruan, K. A. Raymond, K. S. Sandhu, Meizhen Zheng, Ping Wang, Huay Mei Poh, Yufen Goh, Joanne Lim, Jingyao Zhang, Hui Shan Sim, Su Qin Peh, Fabianus Hendriyan Mulawadi, Chin Thing Ong, Yuriy L. Orlov, Shuzhen Hong, Zhizhuo Zhang, Steve Landt, Debasish Raha, Ghia Euskirchen, Chia-Lin Wei, Weihong Ge, Huaien Wang, Carrie Davis, Katherine Fisher, Ali Mortazavi, Mark Gerstein, Thomas Gingeras, Barbara Wold, Yi Sun, Melissa J. Fullwood, Edwin Cheung, Edison Liu, Wing-Kin Sung, Michael Snyder, Yijun Ruan. Extensive Promoter-centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation. Cell. 2012 Jan 20;148 (1- 2):84-98.

ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 Sep 6; 489(7414): 57-74.

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Contact Address

Room 404, Building B

Office Phone

Email

zhengmz@ sustech.edu.cn

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