助理教授 公共卫生及应急管理学院

公共卫生及应急管理学院助理教授,博士生导师。中国科学院武汉病毒研究所博士,德国海德堡大学博士后,2022年加入南方科技大学。主要从事肝炎病毒、天然免疫、以及抗病毒治疗策略等研究,同时向新发病毒,个体化抗病毒免疫和精准防控等领域拓展。主持国家自然科学基金2项,作为主要成员参与国家自然科学基金国际合作项目、德国科学基金(DFG)重大项目等多项。共发表论文30多篇,其中以第一作者和共同第一作者在Journal of Hepatology(4篇),Journal of Immunology,Viruses等期刊发表论文9篇。研究成果多次被国际学术大会选为口头报告,并获得国际肝病大会、美国肝病学会、国际乙肝病毒大会等授予的多项奖励。担任Viruses杂志客座编辑,Journal of Hepatology, Antiviral research, Viruses, Liver International, Antimicrobial Agents and Chemotherapy等杂志审稿人。

课题组长期招收硕士生、博士生、博士后、研究助理、和访问学生,欢迎联系。

个人简介

工作经历

 2022.10-今:          南方科技大学,公共卫生及应急管理学院,助理教授

 2015.09-2022.09:德国海德堡大学,整合传染病研究中心,博士后

                                    合作导师:Stephan Urban教授和Ralf Bartenschlager教授

 2012.09-2015.08:中国科学院武汉病毒研究所,助理研究员

                                    合作导师:王汉中研究员

 

教育经历

 2004.09 - 2012.07:中国科学院武汉病毒研究所,微生物学,博士

 2000.09 – 2004.07:新疆大学,生物技术,本科

 

奖励和荣誉

  • 国际乙型肝炎病毒大会参会资助Free Registration,2022
  • 欧洲肝病协会 (EASL) - 国际肝脏大会青年学者资助 (Young Investigator Bursary) ,2021
  • 美国肝病研究协会年会 (AASLD) 早期职业学者奖 (Early Career Investigator Award) ,2019
  • 国际乙型肝炎病毒大会参会资助 Travel Grant,2019
  • 国际乙型肝炎病毒大会最佳口头报告,2019
  • 国际乙型肝炎病毒大会参会资助 Travel Grant,2018
  • 国际乙型肝炎病毒大会参会资助 Travel Grant,2016
  • 武汉市自然科学优秀学术论文二等奖,2013

 

学术兼职

  • 2023-2024,Viruses杂志客座编辑
  • 欧洲肝病协会(EASL)会员,2019至今
  • 参与组织德国肝病研究协会年会,2019
  • 独立审稿人: Journal of Hepatology, Antiviral research, Viruses, Liver International, Antimicrobial Agents and Chemotherapy等杂志

研究领域

1. 乙型肝炎病毒和丁型肝炎病毒持续性感染机制和新型感染模型;

2. 乙型肝炎和丁型肝炎的治疗策略(核酸类药物、新型疫苗、靶向治疗等);

3. 天然免疫抗病毒机制及其在治疗中的应用;

4. 个体化抗病毒免疫形成的机制与病毒精准防治。


学术成果 查看更多

代表性论文(#共同一作,*通讯作者)

[1] Groth C, Maric J, Lázaro I-G, Hofman T, Zhang Z, Ni Y, Keller F, Seufert I, Hofmann M, Neumann-Haefelin C, Sticht C, Rippe K, Urban S, Cerwenka A. Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity. Frontiers in Immunology. 2023 Dec 8:14:1287367.

[2] Gillich N#, Zhang Z#, Binder M, Urban S, Bartenschlager R. Effect of variants in LGP2 on MDA5-mediated activation of interferon response and suppression of hepatitis D virus replication. Journal of Hepatology. 2023; 78(1):78-89. (#, 共同第一作者)

[3] 张振锋. 丁型肝炎抗体检测方法比较分析. 临床肝胆病杂. 2023, 39(4) 751-757.

[4] Zhang Z, Ni Y, Lempp F.A, Walter L, Mutz P, Bartenschlage R, Urban S. Hepatitis D virus-induced interferon response and administered interferons control cell division-mediated virus spread. Journal of Hepatology. 2022; 77(4):957-966.

[5] Zhang Z, Urban S. New insights into hepatitis D virus persistence: the role of interferon response and implications for upcoming novel therapies. Journal of Hepatology. 2021; 74(3):686-699.

[6] 张振锋, 庄辉. 丁型肝炎实验室诊断研究进展. 中国病毒病杂志, 2021; 11(6):407-413.

[7] Wang W, Lempp FA, Schlund F, Walter L, Decker CC, Zhang Z, Ni Y, Urban S. Assembly and infection efficacy of hepatitis B virus surface protein exchanges in 8 hepatitis D virus genotype isolates. Journal of Hepatology. 2021; 75(2):311-323.

[8] Zhang Z, Urban S. Interplay between Hepatitis D Virus and the Interferon Response. Viruses. 2020; 12(11): 1334.

[9] Ni Y, Zhang Z, Engelskircher L, Verch G, Tu T, Lempp FA, Urban S. Generation and characterization of a stable cell line persistently replicating and secreting the human hepatitis delta virus. Scientific Reports. 2019; volume 9, Article number: 10021.

[10] Lempp FA, Schlund F, Rieble L, Nussbaum L, Link C, Zhang Z, Ni Y, Stephan Urban. Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation. Nature Communications. 2019; 10:2265.

[11] Zhang Z, Filzmayer C, Ni Y, Mutz P, Sültmann H, Hiet M-S, Vondran F W.R., Bartenschlager R, Urban S. Hepatitis D Virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes. Journal of Hepatology. 2018; 69(1):25-35.

[12] Zhang Z, Zehnder B, Damrau C, Urban S. Visualization of hepatitis B virus entry – novel tools and approaches to directly follow virus entry into hepatocytes. FEBS Letters. 2016; 590(13):1915-26.

[13] Lv C, Lin Y, Liu A, Hong Z, Wen L, Zhang Z, Zhang ZL, Wang H, Pang D. Labeling viral envelope lipids with quantum dots by harnessing the biotinylated lipid-self-inserted cellular membrane. Biomaterials. 2016; 106:69-77.

[14] Liu Q, Zhang Z, Zheng Z, Zheng C, Liu Y, Hu Q, Ke X, Wang H. Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65. Scientific Reports. 2016; 6:28481.

[15] Li Q, Zheng Z, Liu Y, Zhang Z, Liu Q, Meng J, Ke X, Hu Q, Wang H. 2C Proteins of Enteroviruses Suppress IKKβ Phosphorylation by Recruiting Protein Phosphatase 1. Journal of Virology. 2016; 90(10): 5141-51.

[16] Liu A, Zhang Z, Sun E, Zheng Z, Zhang ZL, Hu Q, Wang H, Pang D. Simultaneous Visualization of Parental and Progeny Viruses by a Capsid-Specific HaloTag Labeling Strategy. ACS Nano. 2016; 10(1):1147-55.

[17] Zheng C, Zheng Z, Zhang Z, Meng J, Liu Y, Ke X, Hu Q, Wang H. IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1). Cellular Signalling. 2015; 27 (12):2343-54.

[18] Zhang M, Liu Y, Wang P, Guan X, He S, Luo S, Li C, Hu K, Jin W, Du T, Yan Y, Zhang Z, Zheng Z, Wang H, Hu Q. HSV-2 Immediate-Early Protein US1 Inhibits IFN-β Production by Suppressing Association of IRF-3 with IFN-β Promoter. Journal of Immunology. 2015; 194(7):3102-15.

[19] Xu N, Wang J, Zhang Z, Pang DW, Wang H, Zhang ZL. Anisotropic cell-to-cell spread of vaccinia virus on microgrooved substrate. Biomaterials. 2014; 35(19):5049-55.

[20] Zhang X, Shu B, Liu X, Zhang Z, Liu Y, Bai B, Hu Q, Mao P, Wang H. Human Astrocytic Cells Support Persistent Coxsackievirus B3 Infection. Journal of Virology. 2013; 87(22):12407-21.

[21] Zhang F, Zheng Z, Liu SL, Lu W, Zhang Z, Zhang C, Zhou P, Zhang Y, Long G, He Z, Pang DW, Hu Q, Wang H. Self-biotinylation and site-specific double labeling of baculovirus using quantum dots for single-virus in-situ tracking. Biomaterials. 2013; 34(30):7506-18.

[22] Luo H, Zheng Z, Ke X, Zhang X, Li Q, Liu Y, Bai B, Mao P, Hu Q, Wang H. Human Bocavirus VP2 Upregulates IFN-β Pathway by Inhibiting Ring Finger Protein 125-Mediated Ubiquitination of Retinoic Acid-Inducible Gene-I. Journal of Immunology. 2013; 191(2):660-9.

[23] Zheng Z, Ke X, Wang M, He S, Li Q, Zheng C, Zhang Z, Liu Y, Wang H. Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome. Journal of Virology. 2013; 87(10):5645-56. (IF: 6.549)

[24] Zhang Y, Ke X, Zheng Z, Zhang C, Zhang Z, Zhang F, Hu Q, He Z, Wang H. Encapsulating quantum dots into enveloped virus in living cells for tracking virus infection. ACS Nano. 2013; 7(5):3896-904.

[25] Li Q, Zhang Z, Zheng Z, Ke X, Luo H, Hu Q, Wang H. Identification and Characterization of Complex Dual Nuclear Localization Signals in Human Bocavirus NP1. Journal of General Virology. 2013; 94 (Pt 6): 1335-42.

[26] Zhang Z, Zheng Z, Luo H, Meng J, Li H, Li Q, Zhang X, Ke X, Bai B, Mao P, Hu Q, Wang H. Human Bocavirus NP1 Inhibits IFN-β Production by Blocking Association of IFN Regulatory Factor 3 to IFNB Promoter. Journal of Immunology. 2012; 189(3):1144-53.

[27] Jin M, Zhang Z, Zheng Z, Liu Y, Wang H. Methionine-101 from one strain of H5N1 NS1 protein determines its IFN-antagonizing ability and subcellular distribution pattern. Science China-Life Sciences. 2012; 55(11):933-9.

[28] Li Y, Kang QS, Sun GP, Su LJ, Zheng Z, Zhang Z, Wang H, He Z, Huang W. Microchip-based immunoassays with application of silicon dioxide nanoparticle film. Analytical and Bioanalytical Chemistry. 2012; 403(8):2449-57.

[29] Xu N, Zhang Z, Wang L, Gao B, Pang D, Wang H, Zhang ZL. A microfluidic platform for real-time and in situ monitoring of virus infection process. Biomicrofluidics. 6, 034122 (2012).

[30] Tao L, Chen J, Zheng Z, Meng J, Zhang Z, Chen Y, Luo H, Li H, Chen Z, Hu Q, Wang H. H5N1 influenza virus-like particles produced by transient expression in mammalian cells induce humoral and cellular immune responses in mice. Canadian Journal of Microbiology. 2012; 58(4):391-401.

[31] Huang B, Lin Yi, Zhang ZL, Zhuan F, Liu A, Xie M, Tian Z, Zhang Z, Wang H, Pang D. Surface labeling of enveloped viruses assisted by host cells. ACS Chemical Biology. 2012; 7(4):683-8.

[32] Zhou P, Zheng Z, Lu W, Zhang F, Zhang Z, Pang D, Hu B, He Z, Wang H. Multicolor labeling of living-virus particles in live cells. Angewandte Chemie International Edition. 2012; 51(3):670-4.

[33] Zheng Z, Li H, Zhang Z, Meng J, Mao D, Bai B, Lu B, Mao P, Hu Q, Wang H. Enterovirus 71 2C protein inhibits TNF-α-mediated activation of NF-κB by suppressing IκB kinase β phosphorylation. Journal of Immunology. 2011; 187(5):2202-12.

[34] Hu H, Lu X, Tao L, Bai B, Zhang Z, Chen Y, Zheng F, Chen J, Chen Z, Wang H. Induction of specific immune responses by severe acute respiratory syndrome coronavirus spike DNA vaccine with or without interleukin-2 immunization using different vaccination routes in mice. Clinical and Vaccine Immunology. 2007; 14(7):894-901.

[35] Zhuan F, Zhang Z, Xu D, Si Y, Wang H, Mijit G. Tn7-mediated introduction of DNA into bacmid-cloned pseudorabies virus genome for rapid construction of recombinant viruses. Virologica Sinica. 2007; 22:316-325.

国际会议报告

[1] Zhang Z, Walter L, Urban S. Generation of a fluorescent HDV reporter replicon using the split GFP system. 2022 International HBV Meeting (Paris, France). Oral presentation.

[2] Gillich N#, Zhang Z#, Binder M, Urban S, Bartenschlager R. Role of LGP2 in activation of the interferon response and suppression of HDV replication. 2021 International HBV Meeting (Toronto, Canada). Oral presentation. (#, 共同第一作者)

[3] Zhang Z, Walther T, Lempp FA, Ni Y, Urban S. IFN response blocks cell division-mediated HDV spread and suppresses HDV persistence synergistically with antivirals targeting de novo infection. 2021 EASL / International Liver Congress. Oral presentation.

[4] Zhang Z, Walther T, Lempp FA, Ni Y, Urban S. Synergistic suppression of HDV persistence in vitro by co-treatment with investigational drugs targeting both extracellular and cell-division-mediated spreading pathways. 2019 Liver Meeting – AASLD (Boston, USA). Oral presentation.

[5] Zhang Z, Walther T, Lempp FA, Ni Y, Urban S. Synergistic suppression of HDV persistence in vitro by co-treatment with investigational drugs targeting both extracellular and cell-division-mediated spreading pathways. 2019 International HBV Meeting (Melbourne, Australia). Oral presentation.

[6] Zhang Z, Ni Y, Urban S. Endogenous and exogenous IFN responses suppress HDV persistence during proliferation of hepatocytes in vitro. 2019 EASL / International Liver Congress (Vienna, Austria). Poster.

[7] Zhang Z, Ni Y, Urban S. IFN response suppresses HDV persistence during hepatocytes proliferation in vitro. 2018 International HBV Meeting (Taormina, Italy). Oral presentation.

[8] Zhang Z, Mehnert AK, Zehnder B, Bekker C, Seitz S, Bruss V, Urban S. Site-specific labeling of the HBV and HDV envelope using mCherry-S fusion protein. 2017 international HBV meeting (Washington, D.C. USA). Poster.

[9] Zhang Z, Ni Y, Filzmayer C, Sültmann H, Urban S. Hepatitis D Virus replication induces MDA5 mediated IFN-β/λ responses in immune-competent susceptible cells. 2016 international HBV meeting (Seoul, Korea). Oral presentation.

加入团队

课题组长期诚聘博士后、科研助理和访问学生,同时也通过南科大自主培养和境外联合培养项目招收博士和硕士研究生。有意应聘者请将详细简历发送至以下邮箱:zhangzf@sustech.edu.cn。邮件标题请注明“应聘-姓名-毕业院校”,来信时请注明可到岗时间,我们承诺对所接受的全部材料进行严格保密。课题组处于快速成长期,欢迎加入共创未来!
 
(一)博士后岗位要求和薪酬待遇
1)岗位要求

热爱科研,积极向上,对本实验室研究方向有强烈兴趣
近3年内取得或即将取得博士学位,发表至少一篇SCI期刊论文
专业要求:病毒学、免疫学、分子生物学、基础医学、公共卫生、生物信息学等。
工作认真负责,具备独立工作能力和团队协作精神
具有良好的协调沟通能力和优秀的英文读写能力

2)薪酬待遇

博士后聘用期两年,年薪33万元起,含广东省生活补贴15万元及深圳市生活补贴6万元,并按深圳市有关规定参加社会保险及住房公积金。博士后福利费参照学校教职工标准发放。
特别优秀候选人可以申请校长卓越博士后,年薪可达50万元以上。(含广东省及深圳市在站生活补贴)。
在站期间,可依托学校申请深圳市公租房,未依托学校使用深圳市公租房的博士后,可享受两年税前2800元/月的住房补贴。
拥有优良的工作环境和境内外合作交流机会,博士后在站期间享受两年共计2.5万学术交流经费资助。
课题组协助符合条件的博士后申请“广东省海外青年博士后引进项目”。即在世界排名前200名的高校(不含境内,排名以上一年度泰晤士、USNEWS、QS和上海交通大学的世界大学排行榜为准)获得博士学位,在广东省博士后设站单位从事博士后研究,并承诺在站2年以上的博士后,申请成功后省财政给予每名进站博士后资助60万元生活补贴(与广东省每年15万生活补贴不同时享受,与深圳市每年6万元生活补贴同时享受情况以深圳市规定为准);对获得本项目资助,出站后与广东省用人单位签订工作协议或劳动合同,并承诺连续在粤工作3年以上的博士后,省财政给予每人40万元住房补贴。
博士后出站选择留深从事科研工作,且与本市企事业单位签订3年以上劳动(聘用)合同的,可以申请深圳市博士后留深来深科研资助。深圳市政府给予每人每年10万元科研资助,共资助3年(以深圳市最新申报要求为准)。

 
(二)科研教学助理岗位要求、职责及薪酬待遇
1)岗位要求

硕士及以上学历,具有病毒学、免疫学、细胞生物学、分子生物学、动物实验等经验者优先
具备良好的英文读写能力
工作积极主动,认真负责,善于与人交流,能较快适应工作环境

2)岗位职责
(岗位类型I,偏重职责1-2;岗位类型II,偏重职责3-4)

协助课题组科研项目的申报和管理,协助实验室日常管理与合作事宜
协助课题组科研经费管理,负责课题组财务报销等事宜
熟练掌握相关实验技术,负责新成员培训
协助或独立完成实验室的具体科研项目

3)岗位待遇
基本薪资根据学历和经验面议,五险一金,各项福利,补贴等参照学校标准缴纳、发放。
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