Zhang Mingjie

Dean, Chair Professor |School of Life Sciences   Research Group

BSc (Fudan University, China); Ph.D. (University of Calgary, Canada); Member of Chinese Academy of Sciences; Founding Member of the Academy of Sciences of Hong Kong

Founding Dean, School of Life Sciences, Southern University of Science and Technology (SUSTech)

Prof. Mingjie Zhang obtained his bachelor’s degree in chemistry from Fudan University, Shanghai in 1988, and his Ph.D. degree in Biochemistry in the University of Calgary, Canada in 1994. After a brief postdoctoral training in the Ontario Cancer Institute, Toronto, Canada, he established his own laboratory as an Assistant Professor in the Department of Biochemistry, Hong Kong University of Science and Technology (HKUST) in 1995. Before becoming to be the Founding Dean of School of Life Sciences at SUSTech, Prof Zhang was a Kerry Holdings Professor of Science, Senior Fellow of the Institute for Advanced Study, and Chair Professor in the Division of Life Science, HKUST.

Personal Profile

Research

Our laboratory mainly focuses on neuronal structural biology. We aim to understand the molecular mechanisms governing synaptic signal transduction complex organization, dynamic regulations of synaptic complex assemblies, trafficking of proteins involved in synaptic signaling, as well as cell polarity.

➡ Synaptic signal transduction complex organizations by various scaffold proteins (e.g. PDZ domain containing proteins);

 

➡ How protein complexes (e.g. the Par-3/Par-6/aPKC complex and the Usher complex) orchestrate the highly polarized nature of a wide variety of eukaryotic cells including neurons and epithelia.


Publications Read More

  • Feng, Z., Wu, X., and Zhang, M.(2021) “Presynaptic bouton compartmentalization and postsynaptic density-mediated glutamate receptor clustering via phase separation.” . Neuropharmacology, 108622. [Abstract] PDF Full Version
  • Bai G, Zhang, M.(2021). “Clustering acetylcholine receptors in neuromuscular junction by phase-separated Rapsn condensates.” Neuron. 109(12):1907-1909.  [Abstract] PDF Full Version
  • Hosokawa, T., Liu, P. W., Cai, Q., Ferreira, J. S., Levet, F., Butler, C.,Sibarita,J.B., Choquet, D., Groc,L., Hosy,E., Zhang, M. & Hayashi, Y. (2021). “CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation.”Nature Neuroscience , 1-9. [Abstract] PDF Full Version 
  • Wang, X., Ye, F., Wen, Z., Guo, Z., Yu, C., Huang, W. K., Ringeling, F.R.,Su,Y.,Zheng, W.,Zhou, G., Song, H.,Zhang, M., & Ming, G. L. (2019). “Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders. “Molecular psychiatry, 1-15. [Abstract] PDF Full Version 
  • Chen, W., Shen, Z., Asteriti, S., Chen, Z., Ye, F., Sun, Z., Wan,J. Montell,C. Hardie, R. Liu, W. & Zhang, M. (2021). “Calmodulin binds to Drosophila TRP with an unexpected mode. ” Structure, 29(4), 330-344. [Abstract] PDF Full Version 
  • Bai, G., Wang, Y., and Zhang, M.(2021) “Gephyrin-mediated formation of inhibitory postsynaptic. density sheet via phase separation ” Cell Research, 1-14. [Abstract] PDF Full Version 
  • Zhou, S., Han, L., Weng, M., Zhu, H., Heng, Y., Wang, G., … Zhang, M., and Wu, Z.(2021) “Paxbp1 controls a key checkpoint for cell growth and survival during early activation of quiescent muscle satellite cells .” Proceedings of the National Academy of Sciences, 118(13). [Abstract] PDF Full Version 
  • Zang, J., Ye, F., Solbak, S. M., Høj, L. J., Zhang, M., & Bach, A. (2021). “Identification of novel fragments binding to the PDZ1‐2 domain of PSD‐95. “ChemMedChem, 16(6), 949-954. [Abstract] PDF Full Version 
  • Hayashi, Y., Ford, L. K., Fioriti, L., McGurk, L., & Zhang, M. (2021).” Liquid-liquid phase separation in physiology and pathophysiology of the nervous system. “Journal of Neuroscience, 41(5), 834-844. [Abstract] PDF Full Version 
  • Cai, Q., Zeng, M., Wu, X., Wu, H., Zhan, Y., Tian, R., Zhang, M.(2021) “CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation.” Cell Research, 1-15. [Abstract] PDF Full Version 
  • Ye, J., Zou, G., Zhu, R., Kong, C., Miao, C., Zhang, M., Li,J. Xiong,W.& Wang, C. (2021). “Structural basis of GABARAP-mediated GABA A receptor trafficking and functions on GABAergic synaptic transmission.”Nature communications , 12(1), 1-12. [Abstract] PDF Full Version 
  • Wu, X., Ganzella, M., Zhou, J., Zhu, S., Jahn, R., Zhang, M.(2021) “Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates.” Molecular Cell[Abstract] PDF Full Version 
  • Bai, G., & Zhang, M. (2021). “Mesophasic Assembly of Inhibitory Postsynaptic Density. “Neuroscience Bulletin, 37(1), 141-143. [Abstract] PDF Full Version

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Contact Address

1088 Xueyuan Avenue, Biology Hall 312, Nanshan District, Shenzhen 518055, P.R. China

Office Phone

Email

zhangmj@sustech.edu.cn

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