Research Associate Scientist Department of Biomedical Engineering

Dr. Huawei ZHANG is currently a Research Associate Scientist in the Department of Biomedical Engineering, Southern University of Science and Technology. Using structural biology, especially cryo-EM as a tool, he aims to understand the mechanism of Helicobacter pylori pathogenesis, understand the biogenesis of exosomes and their applications in the diagnosis and treatment of osteoarthritis. He obtained his Ph.D. degree in 2017 and then did postdoc work in The Chinese University of Hong Kong until 2019. He has several presentations at international academic conferences and won the Travel Awards. He has published several academic papers and holds one project funded by National Natural Science Foundation of China (NSFC).

Personal Profile

Research

Structural Biology (Cryo-EM and X-ray crystallography)

Biogenesis of exosome

Diagnosis and treatment of osteoarthritis


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代表论文:

● Lam W.W.L., Sun K.L.,ZHANG H.W., Au S.W.N. (2020) Crystal Structure of Flagellar Export Chaperone FliS in Complex With Flagellin and HP1076 of Helicobacter pylori. Front. Microbiol., 2020 May 19;11:787. doi: 10.3389/fmicb.2020.00787. eCollection 2020.

● Qu J.L, Cao S., Wei Q.X., Zhang H.W., Wang R., Kang W., Ma, T., Zhang L., Liu T.G., Au S.W.N.,Sun F., Xia J. (2019) Engineering covalent multienzyme complexes to increase the flux of terpenoid biosynthesis in Escherichia coli. ACS Nano. doi: 10.1021/acsnano.9b03631.

● Kang W., Ma T., Liu M., Qu J.L., Liu Z.J., Zhang H.W., Shi B., Fu S., Ma J.C., Lai L., He S.C., Qu J.N., Au S.W.N., Kang B., Lau W., Deng Z.X., Xia J., Liu T.G. (2019) Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux. Nat commun. 10(1):4248. doi: 10.1038/s41467-019-12247-w.

● Zhang K.M.*, Zhang H.W.*, Li S.S.*, Pintilie G.D., Mou T.C., Gao Y.Z., Zhang Q.F., Bedem H.V.D.,Schmid M.F., Au S.W.N., Chiu W. (2019). Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies at near-atomic resolution. Proc Natl Acad Sci U S A 116 (14) 6800-6805. doi: 10.1073/pnas.1821959116. (* co-first author).

● Lam K.H., Xue C.L., Sun K.L., Zhang H.W., Lam W.W.L., Zhu Z.Y., Ng J.T.Y., Sause W. E.,Lertsethtakarn P., Lau K. F., Ottemann K. M. and Au S.W.N. (2018) Three SpoA-domain proteins interact in the creation of the flagellar type III secretion system in Helicobacter pylori. J. Biol. Chem. 293, 13961-13973. doi: 10.1074/jbc.RA118.002263

● Xue, C.L., Lam, K. H., Zhang, H.W., Sun, K.L., Lee, S.H., Chen, X., and Au, S.W.N. (2017) Crystal structure of the FliF-FliG complex from Helicobacter pylori yields insight into the assembly of the motor MS-C ring in the bacterial flagellum. J. Biol. Chem. 293(6):2066-2078. doi:10.1074/jbc.M117.797936

● Zhang, H.W., Lam, K.H., Lam, W.W.L., Wong, S.Y.Y., Chan, V.S.F., and Au, S.W.N. (2017) A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori. Mol Microbiol. 106 (5): 690-703. doi: 10.1111/mmi.13829.

● Zhang, H.W., and Au, S.W.N. (2017) Helicobacter pylori does not use spermidine synthase to produce spermidine. Biochem Biophys Res Commun 490 (3): 861–867.

● Zhang, H.W., Zeng, X.M., Qi, Q., Sun, K.L., Ma, C.J., Hu, X.J., and Lin, J. (2014) The in vitro interaction of CmeA with CmeC. Chin. Sci. Bull. 59 (25): 3114-3119.

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Join us

The Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), seeks outstanding applicants for full-time tenure-track/tenured faculty positions. Positions are available for both junior and senior-level applicants. Exceptional candidates in any areas are welcome to apply.  The current departmental focus are in the areas of mechanomedicine, biomedical/medical imaging, bioMEMS, regenerative medicine, wearable devices/wireless monitoring, and biomedical data science.

We seek faculty members who can contribute to the excellence and diversity of our academic community. A globally competitive start-up package will be provided to successful candidates. Applicants must possess a Ph.D. degree in biomedical engineering or relevant fields, demonstrated excellent research contributions, and teaching ability.

All applicants should submit the following documents to bmehr@sustech.edu.cn in a single (merged) PDF document: (1) Curriculum Vitae, (2) a Statement of Research and Teaching Interests, (3) up to three representative publications, and (4) 3 letters of reference

SUSTech is a research university that ranks No. 8 in mainland China (Times Higher Education World University Ranking 2019). Established in 2012, SUSTech is a public institution funded by the City of Shenzhen. SUSTech is the first academic institution resulting from the national Chinese Higher Educational Reform. The University’s mission is to become a global institution that is recognized for its academic excellence, innovation, and entrepreneurship. The University promotes bilingual interactions, in which lectures and academic seminars are conducted in both English and Mandarin. SUSTech is determined to cultivate a place where global talents could share their ideas and develop their skills to better contribute to the local and global communities.

Shenzhen is a modern metropolis, where some of the world’s largest technology giants are based. The city is ranked the No.1 most livable city in China (Chinese Cities Livability Development Index Report 2017), with world’s top restaurants, efficient transportation, and extensive green spaces.

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Contact Address

Southern University of Science and Technology Shenzhen, Guangdong, China

Office Phone

Email

zhanghw@sustech.edu.cn

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