Department of Chemistry

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LC-MS-based analytical chemistry and biochemistry to achieve a comprehensive understanding about the occurrence, repair and biological endpoints of DNA damage products.

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1.Yu, Y.; Guerrero, C. R.; Liu, S.; Amato, N. J.; Sharma, Y.; Gupta, S.; Wang, Y., Comprehensive assessment of oxidatively induced modifications of DNA in a rat model of human Wilson’s Disease. Molecular & Cellular Proteomics 2015, 15 (3), 810-817.

2.Yu, Y.; Wang, J.; Wang, P.; Wang, Y., Quantification of Azaserine-Induced Carboxymethylated and Methylated DNA Lesions in Cells by Nanoflow Liquid Chromatography-Nanoelectrospray Ionization Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method. Analytical Chemistry 2016, 88 (16), 8036-8042.

3.Volz, D. C.; Leet, J. K.; Chen, A.; Stapleton, H. M.; Katiyar, N.; Kaundal, R.; Yu, Y.; Wang, Y., Tris(1,3-dichloro-2-propyl)phosphate Induces Genome-Wide Hypomethylation within Early Zebrafish Embryos. Environmental Science & Technology 2016, 50 (18), 10255-10263.

4.Yu, Y.; Cui, Y.; Niedernhofer, L. J.; Wang, Y., Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage. Chemical Research in Toxicology 2016, 29 (12), 2008-2039. (cover article)

5.Chen, X.; Chen, H.; Cai, W.; Maguire, M.; Ya, B.; Zuo, F.; Logan, R.; Li, H.; Robinson, K.; Vanderburg, C. R.; Yu, Y.; Wang, Y.; Fisher, D. E.; Schwarzschild, M. A., The melanoma-linked “redhead” MC1R influences dopaminergic neuron survival. Annals of Neurology 2017, 81(3), 395-406.

6.Yu, Y.; Wang, P.; Cui, Y.; Wang, Y., Chemical Analysis of DNA Damage. Analytical Chemistry 2018, 90 (1), 556-576.

7.Zhang, ZM.; Lu, R.; Wang, P.; Yu, Y.; Chen, D.; Gao, L.; Liu, S.; Ji, D.; Rothbart, S.B.; Wang, Y.; Wang, G.G.; Song, J., Structural basis for DNMT3A-mediated de novo DNA methylation. Nature 2018, 554 (7692), 387-391.

8.Xie, Q.; Wu,T.P.; Gimple, R.C.; Li, Z.; Prager, B.C.; Wu, Q.; Yu, Y.; Wang, P.; Wang, Y.; Gorkin, D.U.; Zhang, C.; Dowiak, A.V.; Lin, K.; Zeng, C.; Sui, Y.; Kim, L.J.Y.; Miller, T.E.; Jiang, L.; Lee, C.H.; Huang, Z.; Fang, X.; Zhai, K.; Mack, S.C.; Sander, M.; Bao, S.; Kerstetter-Fogle, A.E.; Sloan, A.E.; Xiao, A.Z.; Rich, J.N., N6-methyladenine DNA Modification in Glioblastoma.Cell 2018, 175(5),1228-1243.

9.Cui, Y.; Wang, P.; Yu, Y.; Yuan, J.; Wang, Y., Normalized Retention Time for Targeted Analysis of the DNA Adductome. Analytical Chemistry 2018, 90(24),14111-14115.

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