前沿与交叉科学研究院

余晓玲博士,深圳市高层次专业人才“地方级领军人才”。2012至2015年在哈佛大学医学院进行博士后研究(导师Thomas Walz教授,HHMI),主攻方向为生物大分子及膜蛋白的冷冻电镜和晶体结构研究。余博士主要从事肿瘤细胞生物学和结构生物学方面的研究工作,特别是人类重大疾病相关蛋白质和细胞粘附分子的结构和功能研究。2008年获中国免疫学会“免疫学青年学者奖”,2014年获教育部“科学研究技术发明一等奖”。

个人简介

研究领域

◆重大疾病相关蛋白质和细胞粘附分子的结构和功能研究

◆肿瘤与微环境相互作用及信号传导的分子机制研究

◆细胞粘附及信号复合体的组装和结构功能研究


学术成果 查看更多

1. Lees JA, Zhang Y, Oh MS, Schauder CM, Yu X, Baskin JM, Dobbs K, Notarangelo LD, De Camilli P, Walz T, Reinisch KM.Architecture of the human PI4KIIIα lipid kinase complex. Proc Natl Acad Sci U S A. 2017;114(52): 13720-5.

2. Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC. Molecular architecture of the αβ T cell receptor-CD3 complex. Proc Natl Acad Sci U S A. 2014;111(49):17576-81.

3. Yu XL, Hu T, Du JM, Yang XM, Zhang J, Yang B, Shen X, Zhang Z, Zhong WD, Wen N, Ding JP, Jiang H, Zhu P, Chen ZN. Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion. J Biol Chem. 2008;283(26):18056-65.

4. Yu XL, Jiang JL, Li L, Feng Q, Xu J, Chen ZN. The glycosylation characteristic of hepatoma-associated antigen HAb18G/CD147 in human hepatoma cells. Int J Biochem Cell Biol. 2006; 38(11):1939-45.

5. Tang J#, Guo YS#, Yu XL#, Huang W, Zheng M, Zhou YH, Nan G, Wang JC, Yang HJ, Yu JM, Jiang JL, Chen ZN. CD147 reinforces [Ca2+]i oscillations and promotes oncogenic progression in hepatocellular carcinoma. Oncotarget. 2015;6(33):34831-45.

6. Cui HY, Guo T, Wang SJ, Zhao P, Dong ZS, Zhang Y, Jiang JL, Chen ZN, Yu XL*. Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway. Biochem Biophys Res Commun. 2012;419(3):517-22.

7. Guo T#, Yu XL#, Ding Y. The expression of estrogen receptors in rat genioglossus muscle-derived satellite cells and its relationship to intracellular Ca2+ mobilization. Arch Oral Biol. 2010; 55(8):591-8.

8. Tang J, Guo YS, Zhang Y, Yu XL, Li L, Huang W, Li Y, Chen B, Jiang JL, Chen ZN. CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinoma. Cell Death Differ, 2012;19(11):1779-90.

9. Huang W, Luo WJ, Zhu P, Tang J, Yu XL, Cui HY, Wang B, Zhang Y, Jiang JL, Chen ZN. Modulation of CD147-induced matrix metalloproteinase activity: role of CD147 N-glycosylation. Biochem J. 2013;449(2):437-48.

10. Li Y, Wu J, Song F, Tang J, Wang SJ, Yu XL, Chen ZN, Jiang JL. Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin β1 to modulate malignant properties of hepatoma cells. J Biol Chem. 2012;287(7):4759-72.

11. Zhao P, Zhang W, Wang SJ, Yu XL, Tang J, Huang W, Li Y, Cui HY, Guo YS, Tavernier J, Zhang SH, Jiang JL, Chen ZN. HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells. Hepatology, 2011, 54(6): 2012-24.

12. Zhang Z, Yang X, Yang H, Yu X, Li Y, Xing J, Chen Z. New strategy for large-scale preparation of the extracellular domain of tumor-associated antigen HAb18G/CD147 (HAb18GED). J Biosci Bioeng. 2011;111(1):1-6.

13. Xu J, Shen ZY, Chen XG, Zhang Q, Bian HJ, Zhu P, Xu HY, Song F, Yang XM, Mi L, Zhao QC, Tian R, Feng Q, Zhang SH, Li Y, Jiang JL, Li L, Yu XL, Zhang Z, Chen ZN. A randomized controlled trial of Licartin for preventing hepatoma recurrence after liver transplantation. Hepatology. 2007; 45(2): 269-76.

14. Chen ZN, Mi L, Xu J, Song F, Zhang Q, Zhang Z, Xing JL, Bian HJ, Jiang JL, Wang XH, Shang P, Qian AR, Zhang SH, Li L, Li Y, Feng Q, Yu XL, Feng Y, Yang XM, Tian R, Wu ZB, Leng N, Mo TS, Kuang AR, Tan TZ, Li YC, Liang DR, Lu WS, Miao J, Xu GH, Zhang ZH, Nan KJ, Han J, Liu QG, Zhang HX, Zhu P. Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection: clinical phase I/II trials. Int J Radiat Oncol Biol Phys. 2006; 65 (2): 435-44.

15. Chen Z, Mi L, Xu J, Yu J, Wang X, Jiang J, Xing J, Shang P, Qian A, Li Y, Shaw PX, Wang J, Duan S, Ding J, Fan C, Zhang Y, Yang Y, Yu X, Feng Q, Li B, Yao X, Zhang Z, Li L, Xue X, Zhu P. Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus. J Infect Dis. 2005; 191 (5): 755-60.

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