Associate Professor |School of Life Sciences, Department of Biology

Dr.Yu’s research work mainly focus on the structural and functional studies of the proteins involved in cell-ECM adhesion, intracellular trafficking and many neuronal diseases, by combining the powerful tools in biochemistry, biophysics and cell biology. The research results have been published on Cell,Molecular Celletc, and Dr.Yu has been awardedHong Kong Young Scientist Award in Life Science (2009) and the Peacock Plan (2014, Shenzhen)

Personal Profile

Self-introduction
Dr.Yu’s research work mainly focus on the structural and functional studies of the proteins involved in cell-ECM adhesion, intracellular trafficking and many neuronal diseases, by combining the powerful tools in biochemistry, biophysics and cell biology. The research results have been published on Cell,Molecular Celletc, and Dr.Yu has been awardedHong Kong Young Scientist Award in Life Science (2009) and the Peacock Plan (2014, Shenzhen)

Research Interests

  • The structures and functions of proteins involved in cell-ECM(extracellular matrix) adhesion
  • The molecular mechanisms of molecular motors related to disease

Professional Experience

  • 2013-present  Associate Professor, Southern University of Science and Technology of China
  • 2009 –2013    Research Associate in Division of Life Science, the Hong Kong University of Science and Technology

Educational Background

  • Jan. 2004 –Aug. 2009 Ph.D., Biochemistry, the Hong Kong University of Science and Technology
  • Sep. 1998 – Jun.2003  B.S., Biology, University of Science and Technology of China

Honors & Awards

  • 2014 Shenzhen (City) Oversea High-Caliber Personnel, Level B
  • 2013 Recruitment Program of Global Youth Experts of China
  • 2009 Young Scientist Award, The Hong Kong Institution of Science

Committee memberships

  • Council member, Society of Biological Phase Separation and Phase transition, Biophysical Society of China

Organization of conferences, workshops, panels, symposia

  • Organizing committee member, The symposium of phase separation and phase transition in biological systems, China (April, 2021)
  • Organizing committee member, 4th South China Structural Biology Symposium, Shenzhen

Research

◆The structural and functional studies of the core proteins involved in cell and extracellular adhesion

◆The structural and functional studies of the cytoskeleton motors and regulators


Teaching

Teaching Courses

Southern University of Science and Technology

1. BIO102 General Biology (4 credit), 2014-2018

2. BIO102B Introduction to Life Science (3 credit),2020- current

3. BIO201 Biochemistry I (Macromolecules) (3 credit), 2013 – current

4. BIO222 Biochemistry and Molecular Biology Laboratory (2 credit, 4 hours/week), 2013-2015


Publications Read More

Selected Publications

  1. H Yang, L Lin, K Sun, T Zhang, W Chen, L Li, Y Xie, C Wu*, Z Wei*, C Yu*. Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics. eLife Sciences, 10:e64395 (2021).
  2. M Liang, G Jin, X Xie, W Zhang, K Li, F Niu, C Yu*, Z Wei*. Oligomerized Liprin-α Promotes Phase Separation of ELKS for Compartmentalization of Presynaptic Active Zone Proteins. Cell Reports, 34(12):108901 (2021).
  3. F Niu, K Sun, W Wei, C Yu*, Z Wei*. F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis. Science Advances, 6(45):eabb1307 (2020).
  4. X Xie, L Luo, M Liang, W Zhang, T Zhang, C Yu, Z Wei*. Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity. Nature Communications, 11(1): 169 (2020).
  5. H Li, Y Deng, K Sun, H Yang, J Liu, M Wang, Z Zhang, J Lin, C Wu*, Z Wei*, C Yu*. Structural basis of kindlin-mediated integrin recognition and activation. Proc Natl Acad Sci USA, 114(35):9349-9354 (2017).
  6. Z Wei, S Zheng, S A Spangler, C Yu*, C C Hoogenraad, M Zhang*. Liprin-mediated large signaling complex organization revealed by the liprin-alpha/CASK and liprin-alpha/liprin-beta complex structures. Molecular Cell, 43(4):586-98 (2011).
  7.  C Yu, W Feng, Z Wei, Y Miyanoiri, W Wen, Y Zhao, M Zhang*. Myosin VI undergoes cargo-mediated dimerization. Cell, 138(3):537-48 (2009).

Presentations

  1. Invited Speaker, “Phase separation in Focal adhesion dynamics regulation”. 2021 National Symposium on Biological Phase Separation and Phase Transition, Shenzhen, China, 2021
  2. Invited Speaker, “Phase separation in integrin-mediated adhesion”. 2nd Frontier Forum of phase separation of biomolecules, Jixi, China, 2020
  3. Invited Speaker, “From Structure to Function: how kindlin Kindling Integrin Mediated Focal Adhesion”. Gordon Research Conference, Italy, 2019
  4. Invited Speaker, “Biomolecular condensate in Focal Adhesion”. Keystone Symposia on Molecular and Cellular Biology, Snowbird, USA, 2019
  5. Invited Speaker, “Biomolecular condensate in Focal Adhesion”. 1st Frontier Forum of phase separation of biomolecules, Suzhou, China, 2019
  6. Invited Speaker, “Structural Insights into the Integrin-based Adhesions”. Youth team exploration forum of Huazhong University of science and technology, Wuhan, China, 2018
  7. Invited Speaker, “Structural Insights into the Integrin-based Adhesions”. 5th South China Structural Biology Symposium, Fuzhou, China, 2017
  8. Invited Speaker, “How kindlin kindlings integrin activation”. Symposium on Functional Conformational Changes in Complex Biological Systems, HKUST, Hong Kong, 2016
  9. Invited Speaker, “Structural insights into neuronal functions of liprin family proteins”. 4th South China Structural Biology Symposium, Shenzhen, China, 2017

News More

  • SUSTech researchers reveal molecular mechanisms to understand how cells communicate with surrounding environments

    2021-03-22
  • SUSTech researchers reveal a novel mechanism of intracellular logistics

    2020-12-21
  • Achievement: Research of Biology Department Published in PNAS

    2018-08-31

Lab members Read More

Join us

Contact Us

Contact Address

Biological Building B212

Office Phone

0755-88018410

Email

yuc@sustech.edu.cn

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