◆ 细胞与微环境相互作用中重要的分子机理的研究

◆ 疾病相关的分子马达功能的研究

Teaching Courses

Southern University of Science and Technology

1. BIO102 General Biology (4 credit), 2014-2018

2. BIO102B Introduction to Life Science (3 credit),2020- current

3. BIO201 Biochemistry I (Macromolecules) (3 credit), 2013 – current

4. BIO222 Biochemistry and Molecular Biology Laboratory (2 credit, 4 hours/week), 2013-2015

Selected Publications

1. Y Xu, C Guo, W Pan, C Zhao, Y Ding, X Xie, Z Wei*, Y Sun*, C Yu*. Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A. JBC, 297(2):100958 (2021).
2. H Yang, L Lin, K Sun, T Zhang, W Chen, L Li, Y Xie, C Wu*, Z Wei*, C Yu*. Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics. eLife, 10:e64395 (2021).
3. M Liang, G Jin, X Xie, W Zhang, K Li, F Niu, C Yu*, Z Wei*. Oligomerized Liprin-α Promotes Phase Separation of ELKS for Compartmentalization of Presynaptic Active Zone Proteins. Cell Reports, 34(12):108901 (2021).
4. F Niu, K Sun, W Wei, C Yu*, Z Wei*. F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis. Science Advances, 6(45):eabb1307 (2020).
5. X Xie, L Luo, M Liang, W Zhang, T Zhang, C Yu, Z Wei*. Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity. Nature Communications, 11(1): 169 (2020).
6. H Li, Y Deng, K Sun, H Yang, J Liu, M Wang, Z Zhang, J Lin, C Wu*, Z Wei*, C Yu*. Structural basis of kindlin-mediated integrin recognition and activation. Proc Natl Acad Sci USA, 114(35):9349-9354 (2017).
7. Z Wei, S Zheng, S A Spangler, C Yu*, C C Hoogenraad, M Zhang*. Liprin-mediated large signaling complex organization revealed by the liprin-alpha/CASK and liprin-alpha/liprin-beta complex structures. Molecular Cell, 43(4):586-98 (2011).
8.  C Yu, W Feng, Z Wei, Y Miyanoiri, W Wen, Y Zhao, M Zhang*. Myosin VI undergoes cargo-mediated dimerization. Cell, 138(3):537-48 (2009).

Presentations

1. Invited Speaker, “Phase separation in Focal adhesion dynamics regulation”. 2021 National Symposium on Biological Phase Separation and Phase Transition, Shenzhen, China, 2021
2. Invited Speaker, “Phase separation in integrin-mediated adhesion”. 2nd Frontier Forum of phase separation of biomolecules, Jixi, China, 2020
3. Invited Speaker, “From Structure to Function: how kindlin Kindling Integrin Mediated Focal Adhesion”. Gordon Research Conference, Italy, 2019
4. Invited Speaker, “Biomolecular condensate in Focal Adhesion”. Keystone Symposia on Molecular and Cellular Biology, Snowbird, USA, 2019
5. Invited Speaker, “Biomolecular condensate in Focal Adhesion”. 1st Frontier Forum of phase separation of biomolecules, Suzhou, China, 2019
6. Invited Speaker, “Structural Insights into the Integrin-based Adhesions”. Youth team exploration forum of Huazhong University of science and technology, Wuhan, China, 2018
7. Invited Speaker, “Structural Insights into the Integrin-based Adhesions”. 5th South China Structural Biology Symposium, Fuzhou, China, 2017
8. Invited Speaker, “How kindlin kindlings integrin activation”. Symposium on Functional Conformational Changes in Complex Biological Systems, HKUST, Hong Kong, 2016
9. Invited Speaker, “Structural insights into neuronal functions of liprin family proteins”. 4th South China Structural Biology Symposium, Shenzhen, China, 2017