Research Associate Scientist Department of Biomedical Engineering

Yao Mingxi is currently a tenure-track assistant professor in the BME department, SUSTech. His research interests lie in the molecular mechanisms of mechanosensing in health and disease, utilizing diverse techniques such as single molecule manipulation, nano fabrication and advanced bioimaging. Dr Yao has studied the working principle of several important mechanosensing proteins and uncovered novel force-dependent crosstalk between mechanosensitive ion channels and focal adhesions that relates to neoplastic transformation.

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Research

His research interests lie in the molecular mechanisms of mechanosensing in health and disease, utilizing diverse techniques such as single molecule manipulation, nano fabrication and advanced bioimaging.


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Selected Papers:

(1) Yao, Mingxi#; Qiu, Wu#; Liu, Ruchuan; Efremov, Artem K; Cong, Peiwen; Seddiki, Rima; Payre, Manon; Lim, Chwee Teck; Ladoux, Benoit; Mège, René-Marc*; Yan, Jie*; Force-dependent conformational switch of α-catenin controls vinculin binding , Nature Communications, 2014, 5(4525).

(2) Yao, Mingxi#; Goult, Benjamin T#; Klapholz, Benjamin; Hu, Xian; Toseland, Christopher P; Guo, Yingjian; Cong, Peiwen; Sheetz, Michael P*; Yan, Jie*; The mechanical response of talin., Nature Communications, 2016, 7(1): 0-11966.

(3) Yao, Mingxi#; Goult, Benjamin T#; Chen, Hu; Cong, Peiwen; Sheetz, Michael P*; Yan, Jie*; Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation, Scientific Reports, 2014, 4(4610).

(4) Le, Shimin#; Yao, Mingxi#; Chen, Jin; Efremov, Artem K; Azimi, Sara; Yan, Jie*; Disturbance-free rapid solution exchange for magnetic tweezers single-molecule studies, Nucleic Acids Research, 2015, 43(17): e113.

(5) Yao, Mingxi; Chen, Hu; Yan, Jie*; Thermodynamics of force-dependent folding and unfolding of small protein and nucleic acid structures, Integrative Biology, 2015, 7(10): 1154-1160.

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Contact Address

1088 Xueyuan Rd, Nanshan District, Shenzhen, Guangdong 518055, China

Office Phone

Email

yaomx@sustech.edu.cn

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