姚明曦

助理教授 生物医学工程系

姚明曦,南方科技大学生物医学工程系助理教授,博士生导师。研究方向包括:细胞力学感受分子机制,单分子力谱技术,及癌症等重大疾病中力学信号传导与调控等。姚博士先后在新加坡国立大学获得学士,博士学位,并完成博士后研究,师从美国物理学会会士严洁教授及拉斯克奖得主Michael P. Sheetz教授。课题组负责人在单分子水平研究了几个重要力敏感蛋白质的作用原理,并揭示了细胞力敏感钙离子通道与粘着斑通信的力学调控及其与细胞转化的关系,在Nat. Comm., NAR等主流刊物上发表论文多篇,被Science, Nature, Cell, Nature Reviews Materials, Chemical Reviews 等学术期刊引用近1500次,取得了一些在学界具有影响力的创新性成果。 课题组与新加坡国立大学,德州大学医学院,澳大利亚新南威尔士大学,及英国肯特大学研究团队建立有长期深度合作关系。

个人简介

研究领域

研究方向包括:细胞力学感受分子机制,单分子力谱技术,及癌症等重大疾病中力学信号传导与调控等。


学术成果 查看更多

代表性论文:

(1) Yao, Mingxi#; Qiu, Wu#; Liu, Ruchuan; Efremov, Artem K; Cong, Peiwen; Seddiki, Rima; Payre, Manon; Lim, Chwee Teck; Ladoux, Benoit; Mège, René-Marc*; Yan, Jie*; Force-dependent conformational switch of α-catenin controls vinculin binding , Nature Communications, 2014, 5(4525).

(2) Yao, Mingxi#; Goult, Benjamin T#; Klapholz, Benjamin; Hu, Xian; Toseland, Christopher P; Guo, Yingjian; Cong, Peiwen; Sheetz, Michael P*; Yan, Jie*; The mechanical response of talin., Nature Communications, 2016, 7(1): 0-11966.

(3) Yao, Mingxi#; Goult, Benjamin T#; Chen, Hu; Cong, Peiwen; Sheetz, Michael P*; Yan, Jie*; Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation, Scientific Reports, 2014, 4(4610).

(4) Le, Shimin#; Yao, Mingxi#; Chen, Jin; Efremov, Artem K; Azimi, Sara; Yan, Jie*; Disturbance-free rapid solution exchange for magnetic tweezers single-molecule studies, Nucleic Acids Research, 2015, 43(17): e113.

(5) Yao, Mingxi; Chen, Hu; Yan, Jie*; Thermodynamics of force-dependent folding and unfolding of small protein and nucleic acid structures, Integrative Biology, 2015, 7(10): 1154-1160.

(6) Tijore A ,  Yao M ,  Wang Y H , et al. Selective killing of transformed cells by mechanical stretch[J]. Biomaterials, 2021, 275(4302):120866.

(7) Wang Y ,  Yao M ,  Baker K B , et al. Force-dependent interactions between talin and full-length vinculin. Cold Spring Harbor Laboratory, 2021(36).

(8) Efremov, Yao, M., Sun, Y., Tee, Y. H., Sheetz, M. P., Bershadsky, A. D., Martinac, B., & Yan, J. (2022). Application of piconewton forces to individual filopodia reveals mechanosensory role of L-type Ca2+ channels. Biomaterials, 284, 121477–121477. 

(9)Huang, Le, S., Sun, Y., Lin, D. J., Yao, M., Shi, Y., & Yan, J. (2022). Mechanical Stabilization of a Bacterial Adhesion Complex. Journal of the American Chemical Society, 144(37), 16808–16818. 

(10) Guttula D ,  Yao M ,  Baker K , et al. Calcium-mediated Protein Folding and Stabilization of Salmonella Biofilm-associated Protein A – ScienceDirect[J].  2019.

(11) Guo S ,  Tang Q ,  Yao M , et al. Structural-elastic determination of the mechanical lifetime of biomolecules[J].  2018.

(12) Yuan G ,  Le S ,  Yao M , et al. Elasticity of the Transition State Leading to an Unexpected Mechanical Stabilization of Titin Immunoglobulin Domains[J]. Angewandte Chemie, 2017.

(13) Hu, X., Margadant, F.M., Yao, M. and Sheetz, M.P. (2017), Molecular stretching modulates mechanosensing pathways. Protein Science, 26: 1337-1351

(14) Le S ,  Hu X ,  Yao M , et al. Mechanotransmission and Mechanosensing of Human Alpha-actinin 1[J]. Social Science Electronic Publishing.

(15) Yan J ,  Yao M ,  Goult B T , et al. Talin Dependent Mechanosensitivity of Cell Focal Adhesions[J]. Cellular and Molecular Bioengineering, 2015, 8(1):151-159.

(16) Schneider R ,  Huang J R ,  Yao M , et al. Towards a robust description of intrinsic protein disorder using nuclear magnetic resonance spectroscopy[J]. Molecular Biosystems, 2011, 8(1):58-68.

(17) Liu C ,  Yao M ,  Hogue C . Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway[J]. BMC Bioinformatics, 2011, 12(13):S13.

(18)Chen, Oh, D., Dubey, A. K., Yao, M., Yang, B., Groves, J. T., & Sheetz, M. (2018). EGFR family and Src family kinase interactions: mechanics matters? Current Opinion in Cell Biology, 51, 97–102. 

(19)You, Guo, S., Le, S., Tang, Q., Yao, M., Zhao, X., & Yan, J. (2018). Two-State Folding Energy Determination Based on Transition Points in Nonequilibrium Single-Molecule Experiments. The Journal of Physical Chemistry Letters, 9(4), 811–816. 

(20)Winardhi, Tang, Q., Chen, J., Yao, M., & Yan, J. (2016). Probing Small Molecule Binding to Unfolded Polyprotein Based on its Elasticity and Refolding. Biophysical Journal, 111(11), 2349–2357. 

(21) Chen, Yuan, G., Winardhi, R. S., Yao, M., Popa, I., Fernandez, J. M., & Yan, J. (2015). Dynamics of Equilibrium Folding and Unfolding Transitions of Titin Immunoglobulin Domain under Constant Forces. Journal of the American Chemical Society, 137(10), 3540–3546. 

(22) Ozenne, Schneider, R., Yao, M., Huang, J., Salmon, L., Zweckstetter, M., Jensen, M. R., & Blackledge, M. (2012). Mapping the Potential Energy Landscape of Intrinsically Disordered Proteins at Amino Acid Resolution. Journal of the American Chemical Society, 134(36), 15138–15148. 

(23) Leyrat, Schneider, R., Ribeiro, E. A., Yabukarski, F., Yao, M., Gérard, F. C. A., Jensen, M. R., Ruigrok, R. W. H., Blackledge, M., & Jamin, M. (2012). Ensemble Structure of the Modular and Flexible Full-Length Vesicular Stomatitis Virus Phosphoprotein. Journal of Molecular Biology, 423(2), 182–197. 

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南方科技大学力学生物学实验室由新加坡国立大学、深圳市“孔雀计划”人才姚明曦教授建立,致力于在单分子水平研究了几个重要力敏感蛋白质的作用原理,并揭示了细胞力敏感钙离子通道(如Piezo1)与粘着斑通信的力学调控及其与细胞转化的关系的研究,主要的研究方向有细胞力学感受分子机制,单分子力谱技术,及癌症等重大疾病中力学信号传导与调控等。现公开招聘课题组博士后、博士、研究助理等职位。
一、应聘条件
有生物学、生物医学工程、化学、物理等领域背景;既往从事过生物学相关科研经历具有细胞培养、DNA提纯、微纳米、蛋白表达等相关研究背景者优先;并且对生物医学工程交叉学科具有强烈兴趣的学者,均可报名。
二、岗位待遇
(1)先进的科研设施与浓厚的科研氛围,按照南方科技大学相关岗位薪酬管理规定执行,在职期间为聘用人员购买"五险一金"等,我们将为招聘的人才提供具有市场竞争力的薪酬待遇。
(2)博士后年薪不低于35万,含广东省补助15万元及深圳市生活补助6万,并按照深圳市有关规定享受社会保险和住房公积金,此外还享受过节费、餐补、计划生育奖励、高温补贴、免费体检等福利待遇;特别优秀者可以入选校长卓越奖励计划,年薪可达41.5万年薪(含广东省及深圳市补助)。条件优秀、有高校工作经历、博士后经历者也可以申请研究副教授或助理教授职位,年薪35万起。
(3)研究助理月薪5000元起(本科)或7000元起(硕士),有经验者可适当调整,表现优秀者可以申请南科大和国外大学(境外)合作培养研究生项目或南科大和国内一流大学(境内)合作培养的研究生项目。
三、联系我们
请提交个人简历 ,中英文均可,将申请材料发至:yaomx@sustech.edu.cn ,邮件标题请注明“XXX应聘力学生物学实验室”,通过初选者将及时安排面试并对申请个人信息严格保密。
四、截止日期
长期有效,直到岗位招满为止。
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联系地址

广东省深圳市南山区学苑大道1088号

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yaomx@sustech.edu.cn

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