Assistant Professor |School of Medicine, School of Medicine
Yang Xu Ph.D., Tenure-track assistant professor & doctoral supervisor at SUSTech School of Medicine. Dr. Xu graduated from Baylor College of Medicine (Houston, TX) in 2015 with a Ph.D degree in Immunology and finished his post-doc training at the Lineberger Comprehensive Cancer Center at University of North Carolina at Chapel Hill from 2015 to 2020. Dr. Xu’s research focus on CAR-T cell immunology for cancer and basic T cell biology and he published 8 research articles in high-impact journals such as Nature Biotechnology, Blood, Journal of Clinical Investigation, Cancer Cell, etc.
Dr. Xu focuses on improving the efficacy of CAR-T cell immunotherapies in solid tumors by studying the molecular and cellular signatures of solid tumor microenvironment.
My research focus includes:
Development of novel chemotaxis system in CAR-T cells to facilitate tumor infiltration.
Investigate T cell metabolism to improve metabolic fitness of CAR-T cells in tumor.
Investigate the molecular mechanism of functional exhaustion of CAR-T cells and the functions of inhibitory receptors in CAR-T cell signaling.
Meanwhile, we also have collaboration with other laboratories in the U.S. on projects involving T cell differentiation and T cell signaling.
MED5013 Basic Immunology Seminars