Associate Professor Department of Chemistry

Xiaojiang obtained his Bachelor degree at Nanjing University in China (2004-2008), and his Master and Ph.D degrees at the University of Geneva with Prof. Eric Bakker (2010-2015). He also had a Postdoc experience at ENS Paris with Prof. Ludovic Jullien and Prof. Thomas Le Saux before joining the Department of Chemistry at SUSTech in Oct. 2016. In 2017, he was awarded with the Young Thousand Talent Program by the Chinese government, and in 2018 he was awarded the Prix Schläfli in Chemistry by the Swiss Academy of Sciences.

Personal Profile

Educational Background:
06.2012 ̶ 07.2015, Ph.D, University of Geneva, Switzerland
09.2010 ̶ 06.2012, Master, University of Geneva, Switzerland
09.2004 ̶ 06.2008, Bachelor, Nanjing University, China
-Prix Schläfli, Chemistry (Swiss Academy of Science, 2018)
-Young Thousand Talent (The Organization Department of The Central Committee, 2017)
-Young Investigators (Analytical and Bioanalytical Chemistry, 2016)
-Metrohm Award (Swiss Chemical Society, 2014)
-Chinese Government Award for Outstanding Self-Financed Students Abroad (2014)


-Chemical sensors (ion, gas, nucleic acids, proteins, etc. )

-Fluorescent nanoprobes and subcellular microscopic imaging

-Photochromism, photoswitching, and their applications

-Analysis&Sensing with electrochemical and optical approaches


Analytical Chemistry (undergraduate course, Spring and Fall Semesters)

Principles of Instrumental Analysis (undergraduate course, Spring Semester)

Publications Read More

Independent work:

(72)Wei Yang, Jingying Zhai, Jing Li, Yu Qin, Yaotian Wu, Yupu Zhang, Xiaojiang Xie*, Colorimetric and Fluorescent Turn-on Detection of Chloride Ions with Ionophore and BODIPY: Evaluation with Nanospheres and Cellulose Paper. Analytica Chimica Acta, 2021, 1175: 338752.

(71) Chao Guo, Jingying Zhai, Yifu Wang, Wei Yang, Xiaojiang Xie*, “Wash-free Detection of Nucleic Acids with Photoswitch-Mediated Fluorescence Resonance Energy Transfer Against Optical Background Interference”, Analytical Chemistry, 2021, 93, 8128-8133

(70) Xinfeng Du, Jingying Zhai, Xiaoang Li, Yupu Zhang, Niping Li, Xiaojiang Xie*, “Hydrogel-based Optical Ion Sensors: Principles and Challenges for Point-of-care Testing and Environmental Monitoring”, ACS Sensors, 2021, 6, 1990-2001

(69) Jingying Zhai, Yaotian Wu, Xiaojiang Xie*, “Single-Component Chemical Nose with a Hemicyanine Probe for Pattern-Based Discrimination of Metal Ions”, Chinese Journal of Chemistry, 2021, 39, 1517-1522 (Dedicated to Department of Chemistry, SUSTech, on the Occasion of Her 10th Anniversary.)

(68) Yashu Wang, Jingyi Fan, Mengsi Li, Xiaojiang Xie, Xiangru Meng, Jie Ding*, Hong-Wei Hou*, “Expanding benzothiadiazole-tetrazole photo-triggered click reaction with chloride ion into reaction-based chloride ion receptor” Dyes and Pigments, 2021, 191, 109345

(67)Li Deng, Jingying Zhai, Xinfeng Du, and Xiaojiang Xie*,“Ionophore-Based Ion-Selective Nanospheres Based on Monomer–Dimer Conversion in the Near-Infrared Region”, ACS Sensors, 2021, 6, 3, 1279-1285

(66) Xinfeng Du, Xiaojiang Xie*, “Ion-Selective optodes: Alternative approaches for simplified fabrication and signaling”, Sensors and Actuators B: Chemical, 2021, 335, 129368

(65) Qinghan Chen, Liu-Pan Yang, Dong-Hao Li, Jingying Zhai*, Wei Jiang*, Xiaojiang Xie*, “Potentiometric determination of the neurotransmitter acetylcholine with ion-selective electrodes containing oxatub[4]arenes as the ionophore”, Sensors and Actuators B: Chemical , 2021, 326, 128836

(64) Jing Li, Jingying Zhai, Yifu Wang, Wei Yang, Xiaojiang Xie*, “Dual functional luminescent nanoprobes for monitoring oxygen and chloride concentration changes in cells”, Chem. Commun. 2020, 56, 14980-14983

(63) Xinfeng Du, Jingying Zhai, Dingxuan Zeng, Fangyi Chen*, Xiaojiang Xie*, “Distance-based Detection of Calcium Ions with Hydrogels Entrapping Exhaustive Ion-Selective Nanoparticles”, Sensors and Actuators B: Chemical , 2020, 319, 128300

(62) Wang Renjie, Du Xinfeng, Ma Xueqing, Zhai Jingying, Xie Xiaojiang*,”Ionophore-based pH independent detection of ions utilizing aggregation-induced effects”, Analyst, 2020,145,3846-3850

(61) Wenyue Gao, Xiaojiang Xie*, and Eric Bakker*, “Direct Potentiometric Sensing of Anion Concentration (Not Activity)”, ACS Sensors, 2020, 5, 313-318

(60) Xinfeng Du, Renjie Wang, Jingying Zhai, Xiaoang Li, and Xiaojiang Xie*, “Ionophore-based Ion-Selective Nanosensors from Brush Block Copolymer Nanodots”, ACS Appl. Nano Mater. 2020, 3, 1, 782-788

(59)Xiaoang Li, Jingying Zhai, and Xiaojiang Xie*, “The Hofmeister Anion Effect on Ionophore‐based Ion‐selective Nanospheres Containing Solvatochromic Dyes”, Electroanalysis, 2020, 32, 749-754

(58) Wenyue Gao, Elena Zdrachek, Xiaojiang Xie*, and Eric Bakker*, “A Solid-State Reference Electrode Based on a Self-Referencing Pulstrode”, Angew. Chem. Int. Ed., 2020, 132(6),2314-2318.

(57) Wei Yang, Jingying Zhai, Xiaojiang Xie*, “Rhodamine dye transfer from hydrogel to nanospheres for the chemical detection of potassium ions”, Analyst, 2019, 144, 5617

(56) Qinghan Chen, Xiaoang Li, Renjie Wang, Fanxin Zeng, Jingying Zhai*, Xiaojiang Xie*, “Rapid Equilibrated Colorimetric Detection of Protamine and Heparin: Recognition at the Nanoscale Liquid–Liquid Interface”, Anal. Chem. 2019, 91, 10390

(55) Lu Wang, Stephanie Sadler, Tianchi Cao, Xiaojiang Xie, Joachim Moser Von Filseck, Eric Bakker* “Simplified Fabrication for Ion-Selective Optical Emulsion Sensor with Hydrophobic Solvatochromic Dye Transducer: A Cautionary Tale”, Anal. Chem. 2019, 91, 8973

(54) Li Deng, Jingying Zhai, and Xiaojiang Xie* “A Chemiluminescent Ion Sensing Platform Based on Ionophores”, Anal. Chem. 2019, 91, 8638

(53) Renjie Wang, Xinfeng Du, Jingying Zhai, and Xiaojiang Xie* “Distance and Color Change Based Hydrogel Sensor for Visual Quantitative Determination of Buffer Concentrations”, ACS Sensors 2019, 4, 1017

(52) Wenyue Gao, Stéphane Jeanneret, Dajing Yuan, Thomas Cherubini, Lu Wang, Xiaojiang Xie*, and Eric Bakker* “Electrogenerated Chemiluminescence for Chronopotentiometric Sensors”, Anal. Chem., 2019, 91, 4889

(51) Fei Jia, Henrik Hupatz, Liu-Pan Yang, Hendrik V. Schröder, Dong-Hao Li, Shan Xin, Dieter Lentz, Felix Witte, Xiaojiang Xie, Beate Paulus, Christoph A. Schalley*, and Wei Jiang* “Naphthocage: A Flexible yet Extremely Strong Binder for Singly Charged Organic Cations”, J. Am. Chem. Soc.,2019,141 (10), 4468–4473

(50) Xinfeng Du, Manling Huang, Renjie Wang, Jingying Zhai, and Xiaojiang Xie*, A Rapid Point-of-Care Optical Ion Sensing Platform Based on Target-Induced Dye Release from Smart Hydrogels, Chem. Commun., 2019, 55, 1774

(49) Renjie Wang, Xinfeng Du, Yaotian Wu, Jingying Zhai, and Xiaojiang Xie*, Graphene Quantum Dots Integrated in Ionophore-Based Fluorescent Nanosensors for Na+ and K+, ACS Sensors, 2018, 3 (11), 2408

(48) Jingying Zhai, Liyuan Yang, Xinfeng Du, and Xiaojiang Xie* Electrochemical-to-Optical Signal Transduction for Ion-Selective Electrodes with Light-Emitting Diodes, Anal. Chem., 2018, 90 (21), 12791

(47) Changyou Zhu, Manling Huang, Jialing Lan, Lung Wa Chung, Xin Li*, and Xiaojiang Xie* Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode, ACS Omega, 2018, 3 (10), 12476

(46) Lu Wang, Xiaojiang Xie, Tianchi Cao, Jerôme Bosset, and Eric Bakker*,  Surface-Doped Polystyrene Microsensors Containing Lipophilic Solvatochromic Dye Transducers, Chem. Eur. J. 2018, 24, 1

(45) Xinfeng Du, Liyuan Yang, WenChang Hu, Renjie Wang, Jingying Zhai, and Xiaojiang Xie*, A Plasticizer-Free Miniaturized Optical Ion Sensing Platform with Ionophores and Silicon-Based Particles, Anal. Chem. 2018, 90 (9), 5818

(44) Coll Crespi, M.; Crespo, G. A.; Xie, X.; Touilloux, R.; Tercier-Waeber, M.; Bakker, E*., Agarose hydrogel containing immobilized pH buffer microemulsion without increasing permselectivity, Talanta 2018, 177, 191

(43) Zhai, J.; Zhu, C.; Peng, X.; Xie, X.* Ionophore-based Heterogeneous Calcium Optical Titration. Electroanalysis, 2018, 30 (4), 705

(42) Querard, J.; Zhang, R.; Kelemen, Z.; Plamont, M.-A.; Xie, X.; Chouket, R.; Roemgens, I.; Korepina, Y.; Albright, S.; Ipendey, E.; Volovitch, M.; Sladitschek, H. L.; Neveu, P.; Gissot, L.; Gautier, A. Faure, J.-D.; Croquette, V.; Le Sausx, T.*; Jullien, L.* Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations. Nature Communications. 2017, 8 (1), 969

(41) Xinfeng Du, Xiaojiang Xie* Non-Equilibrium Diffusion Controlled Ion-Selective Optical Sensor for Blood Potassium Determination. ACS Sensors 2017, 2 (10), 1410

(40) Xinfeng Du, Changyou Zhu, Xiaojiang Xie* Thermochromic Ion-Exchange Micelles Containing H+ Chromoionophores. Langmuir 2017, 33 (23), 5910.

Before SUSTech:

(39) Zhai, J.; Xie, X.; Cherubini, T.; Bakker, E.* Ionophore-Based Titrimetric Detection of Alkali Metal Ions in Serum. ACS Sens. 2017, 2 (4), 606.

(38) Xie, X.* Renovating the chromoionophores and detection modes in carrier-based ion-selective optical sensors. Anal. Bioanal. Chem. 2016, 408 (11), 2717.

(37) Xie, X.*; Zhai, J.; Jarolimova, Z.; Bakker, E.* Determination of pK(a) Values of Hydrophobic Colorimetric pH Sensitive Probes in Nanospheres. Anal. Chem. 2016, 88 (6), 3015.

(36) Wang, L.; Xie, X.; Zhai, J.; Bakker, E.* Reversible pH-independent optical potassium sensor with lipophilic solvatochromic dye transducer on surface modified microporous nylon. Chem. Commun.  2016, 52 (99), 14254.

(35) Xie, X.* Szilagyi, I; Zhai, J.; Wang, L.; Bakker, E.* Ion-Selective Optical Nanosensors Based on Solvatochromic Dyes of Different Lipophilicity: From Bulk Partitioning to Interfacial Accumulation. ACS Sens. 2016, 1 (5), 516

(34) Zhai, J.; Xie, X.; Bakker, E.* Ion-selective optode nanospheres as heterogeneous indicator reagents in complexometric titrations. Anal. Chem. 2015, 87 (5), 2827.

(33) Zhai, J.; Xie, X.; Bakker, E.* Anion-exchange nanospheres as titration reagents for anionic analytes. Anal. Chem. 2015, 87 (16), 8347.

(32) Zhai, J.; Xie, X.; Bakker, E.* Solvatochromic Dyes as pH-Independent Indicators for Ionophore Nanosphere-Based Complexometric Titrations. Anal. Chem. 2015, 87 (24), 12318.

(31) Xie, X.*; Gutierrez, A.; Trofimov, V.; Szilagyi, I.; Soldati, T.; Bakker, E.* Charged solvatochromic dyes as signal transducers in pH independent fluorescent and colorimetric ion selective nanosensors. Anal. Chem. 2015, 87 (19), 9954.

(30) Xie, X.*; Gutierrez, A.; Trofimov, V.; Szilagyi, I.; Soldati, T.; Bakker, E.* Potassium Sensitive Optical Nanosensors Containing Voltage Sensitive Dyes. Chimia 2015, 69 (4), 196.

(29) Xie, X.*; Bakker, E.* Ion selective optodes: from the bulk to the nanoscale. Anal. Bioanal. Chem. 2015, 407 (14), 3899.

(28) Xie, X.*; Bakker, E.* Determination of Effective Stability Constants of Ion-Carrier Complexes in Ion Selective Nanospheres with Charged Solvatochromic Dyes. Anal. Chem. 2015, 87 (22), 11587.

(27) Xie, X.; Crespo, G. A.; Mistlberger, G.; Bakker, E.* Photocurrent generation based on a light-driven proton pump in an artificial liquid membrane. Nat. Chem. 2014, 6 (3), 202.

(26) Zhai, J.; Xie, X.; Bakker, E.* Ionophore-based ion-exchange emulsions as novel class of complexometric titration reagents. Chem. Commun. 2014, 50 (84), 12659.

(25) Xie, X.; Zhai, J.; Bakker, E.* Potentiometric response from ion-selective nanospheres with voltage-sensitive dyes. J. Am. Chem. Soc. 2014, 136 (47), 16465.

(24) Xie, X.*; Bakker, E.* Photoelectric conversion based on proton-coupled electron transfer reactions. J. Am. Chem. Soc. 2014, 136 (22), 7857.

(23) Zhai, J.; Xie, X.; Bakker, E.* Advancing Schwarzenbach’s Complexometry: Nano-scale Titration Reagents Based on Heterogeneous Reactions. Chimia 2014, 68 (12), 899.

(22) Xie, X.; Zhai, J.; Crespo, G. A.; Bakker, E.* Ionophore-based ion-selective optical nanosensors operating in exhaustive sensing mode. Anal. Chem. 2014, 86 (17), 8770.

(21) Xie, X.; Zhai, J.; Bakker, E.* pH independent nano-optode sensors based on exhaustive ion-selective nanospheres. Anal. Chem. 2014, 86 (6), 2853.

(20) Xie, X.*; Crespo, G. A.; Zhai, J.; Szilagyi, I.; Bakker, E.* Potassium-selective optical microsensors based on surface modified polystyrene microspheres. Chem. Commun. 2014, 50 (35), 4592.

(19) Xie, X.*; Bakker, E.* Light-controlled reversible release and uptake of potassium ions from ion-exchanging nanospheres. ACS Appl. Mater. Interfaces 2014, 6 (4), 2666.

(18) Xie, X.*; Bakker, E.* Creating electrochemical gradients by light: from bio-inspired concepts to photoelectric conversion. Phys. Chem. Chem. Phys. 2014, 16 (37), 19781.

(17) Xie, X.; Mistlberger, G.; Bakker, E.* Visible light induced photoacid generation within plasticized PVC membranes for copper (II) ion extraction. Sensors and Actuators B: Chemical 2014, 204, 807

(16) Jarolimova, Z.; Crespo, G. A.; Xie, X.; Ghahraman Afshar, M.; Pawlak, M.; Bakker, E.* Chronopotentiometric carbonate detection with all-solid-state ionophore-based electrodes. Anal. Chem. 2014, 86 (13), 6307.

(15) Eric Bakker, Mary-Lou Tercier-Waeber, Thomas Cherubini, Miquel Coll Crespi, Gastón A Crespo, Maria Cuartero, Majid Ghahraman Afshar, Zdenka Jarolimova, Stéphane Jeanneret, Sandrine Mongin, Bastien Néel, Nadezda Pankratova, Romain Touilloux, Xiaojiang Xie, Jingying Zhai, Environmental Sensing of Aquatic Systems at the University of Geneva. Chimia 2014, 68 (11), 772.

(14) Afshar, M. G.; Crespo, G. A.; Xie, X.; Bakker, E.* Direct alkalinity detection with ion-selective chronopotentiometry. Anal. Chem. 2014, 86 (13), 6461.

(13) Xie, X.*; Bakker, E.* Detecting and manipulating ions. Q&More (Spotlight on: Bioanalytics | Ion Sensors ) 2014, 02.14

(12) Bakker, E*, and Xie, X.*, Shrinking Ion-selective Sensors for Success. The Analytical Scientist, 2014, 09/23/2014

(11) Xie, X.; Mistlberger, G.; Bakker, E.* Ultrasmall fluorescent ion-exchanging nanospheres containing selective ionophores. Anal. Chem. 2013, 85, 9932

(10) Xie, X.; Crespo, G. A.; Bakker, E.* Oxazinoindolines as fluorescent H+ turn-on chromoionophores for optical and electrochemical ion sensors. Anal. Chem. 2013, 85 (15), 7434

(9) Xie, X.; Bakker, E.* Non-Severinghaus potentiometric dissolved CO2 sensor with improved characteristics. Anal. Chem. 2013, 85 (3), 1332

(8) Mistlberger, G.*; Xie, X.; Pawlak, M.; Crespo, G. A.; Bakker, E.* Photoresponsive ion extraction/release systems: dynamic ion optodes for calcium and sodium based on photochromic spiropyran. Anal. Chem. 2013, 85 (5), 2983

(7) Eric Bakker*, Ewa Grygolowicz-Pawlak, Xiaojiang Xie, Günter Mistlberger, Gaston Crespo, Majid Afshar, Bastien Néel, Alexey Shvarev, Modern chemical ion sensor concepts based on electrochemically and optically triggered phase transfer. Anal. Chem., 2012, 66, 479

(6) Xie, X.; Pawlak, M.; Tercier-Waeber, M. L.; Bakker, E.* Direct optical carbon dioxide sensing based on a polymeric film doped with a selective molecular tweezer-type ionophore. Anal. Chem. 2012, 84 (7), 3163

(5) Xie, X.; Mistlberger, G.; Bakker, E.* Reversible photodynamic chloride-selective sensor based on photochromic spiropyran. J. Am. Chem. Soc. 2012, 134 (41), 16929

(4) Mistlberger, G.; Crespo, G. A.; Xie, X.; Bakker, E.* Photodynamic ion sensor systems with spiropyran: photoactivated acidity changes in plasticized poly(vinyl chloride). Chem. Commun. 2012, 48 (45), 5662

(3) Bakker, E.*; Crespo, G.; Grygolowicz-Pawlak, E.; Mistlberger, G.; Pawlak, M.; Xie, X. Advancing membrane electrodes and optical ion sensors. Chimia 2011, 65 (3), 141

(2) Xie, X.; Qin, Y.* A dual functional near infrared fluorescent probe based on the bodipy fluorophores for selective detection of copper and aluminum ions. Sensors and Actuators B: Chemical 2011, 156 (1), 213

(1) Xie, X.; Li, X.; Ge, Y.; Qin, Y.*; Chen, H.-Y. Rhodamine-based ratiometric fluorescent ion-selective bulk optodes. Sensors and Actuators B: Chemical 2010, 151 (1), 71

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