Associate Professor Department of Chemistry

Xiaojiang obtained his Bachelor degree at Nanjing University in China and then under the supervision of Prof. Eric Bakker, he obtained the Master and Ph.D degrees, respectively, at the University of Geneva. He then did a postdoc at ENS Paris working with Prof. Ludovic Jullien and Prof. Thomas Le Saux before joining the Department of Chemistry at SUSTech. In 2017, he was awarded with the Young Thousand Talent Program by the Chinese government. In 2018, he was awarded the Prix Schläfli in Chemistry by the Swiss Academy of Sciences. His current research revolves around 1) developing novel chemical and biological sensing principles at the nanoscale phase-innterface, and 2) Photoswitching, photochromism, and related applications.

Personal Profile

Educational Background:
06.2012 ̶ 07.2015, Ph.D, University of Geneva, Switzerland
09.2010 ̶ 06.2012, Master, University of Geneva, Switzerland
09.2004 ̶ 06.2008, Bachelor, Nanjing University, China
-Prix Schläfli, Chemistry (Swiss Academy of Science, 2018)
-Young Thousand Talent (The Organization Department of The Central Committee, 2017)
-Young Investigators (Analytical and Bioanalytical Chemistry, 2016)
-Metrohm Award (Swiss Chemical Society, 2014)
-Chinese Government Award for Outstanding Self-Financed Students Abroad (2014)


-Potoswitch, Photochromism, and related applications

-Chemical and biological sensors (ion, gas, nucleic acids, proteins, etc. )


Analytical Chemistry (undergraduate course, Spring and Fall Semesters)

Principles of Instrumental Analysis (undergraduate course, Spring Semester)

Publications Read More


(75) Yinghong Tang, Jingying Zhai*, Qinghan Chen, and Xiaojiang Xie*, Ruthenium Bipyridine Complexes as Electrochemiluminescent Transducers for Ionophore-based Ion-Selective Detection. Analyst2021,

(74) Qinghan Chen, Jingying Zhai, Jing Li, Yifu Wang, and Xiaojiang Xie*, Exploring ratiometric endolysosomal pH nanosensors with hydrophobic indicators responding at the nanoscale interface and multiple fluorescence resonance energy transfers. Nano Research2021,

(73) Jing Li, Xueqing Ma, Wei Yang, Chao Guo, Jingying Zhai, and Xiaojiang Xie*, Enhanced Sulfite-Selective Sensing and Cell Imaging with Fluorescent Nanoreactors Containing a Ratiometric Lipid Peroxidation Sensor. Analytical Chemistry,  20219334, 11758-11764

(72)Wei Yang, Jingying Zhai, Jing Li, Yu Qin, Yaotian Wu, Yupu Zhang, Xiaojiang Xie*, Colorimetric and Fluorescent Turn-on Detection of Chloride Ions with Ionophore and BODIPY: Evaluation with Nanospheres and Cellulose Paper. Analytica Chimica Acta2021, 1175: 338752.

(71) Chao Guo, Jingying Zhai, Yifu Wang, Wei Yang, Xiaojiang Xie*, Wash-free Detection of Nucleic Acids with Photoswitch-Mediated Fluorescence Resonance Energy Transfer Against Optical Background Interference. Analytical Chemistry2021, 93, 8128-8133

(70) Xinfeng Du, Jingying Zhai, Xiaoang Li, Yupu Zhang, Niping Li, Xiaojiang Xie*, Hydrogel-based Optical Ion Sensors: Principles and Challenges for Point-of-care Testing and Environmental Monitoring. ACS Sensors2021, 6, 1990-2001

(69) Jingying Zhai, Yaotian Wu, Xiaojiang Xie*, Single-Component Chemical Nose with a Hemicyanine Probe for Pattern-Based Discrimination of Metal Ions. Chinese Journal of Chemistry2021, 39, 1517-1522 (Dedicated to Department of Chemistry, SUSTech, on the Occasion of Her 10th Anniversary.)

(68) Yashu Wang, Jingyi Fan, Mengsi Li, Xiaojiang Xie, Xiangru Meng, Jie Ding*, Hong-Wei Hou*, Expanding benzothiadiazole-tetrazole photo-triggered click reaction with chloride ion into reaction-based chloride ion receptor. Dyes and Pigments2021, 191, 109345

(67)Li Deng, Jingying Zhai, Xinfeng Du, and Xiaojiang Xie*,Ionophore-Based Ion-Selective Nanospheres Based on Monomer–Dimer Conversion in the Near-Infrared Region. ACS Sensors2021, 6, 3, 1279-1285

(66) Xinfeng Du, Xiaojiang Xie*, Ion-Selective optodes: Alternative approaches for simplified fabrication and signaling. Sensors and Actuators B: Chemical, 2021, 335, 129368

(65) Qinghan Chen, Liu-Pan Yang, Dong-Hao Li, Jingying Zhai*, Wei Jiang*, Xiaojiang Xie*, Potentiometric determination of the neurotransmitter acetylcholine with ion-selective electrodes containing oxatub[4]arenes as the ionophore. Sensors and Actuators B: Chemical2021, 326, 128836

(64) Jing Li, Jingying Zhai, Yifu Wang, Wei Yang, Xiaojiang Xie*, Dual functional luminescent nanoprobes for monitoring oxygen and chloride concentration changes in cells. Chemical Communications2020, 56, 14980-14983

(63) Xinfeng Du, Jingying Zhai, Dingxuan Zeng, Fangyi Chen*, Xiaojiang Xie*, Distance-based Detection of Calcium Ions with Hydrogels Entrapping Exhaustive Ion-Selective Nanoparticles. Sensors and Actuators B: Chemical , 2020, 319, 128300

(62) Wang Renjie, Du Xinfeng, Ma Xueqing, Zhai Jingying, Xie Xiaojiang*,Ionophore-based pH independent detection of ions utilizing aggregation-induced effects. Analyst2020, 145, 3846-3850

(61) Wenyue Gao, Xiaojiang Xie*, and Eric Bakker*, Direct Potentiometric Sensing of Anion Concentration (Not Activity). ACS Sensors, 2020, 5, 313-318

(60) Xinfeng Du, Renjie Wang, Jingying Zhai, Xiaoang Li, and Xiaojiang Xie*, Ionophore-based Ion-Selective Nanosensors from Brush Block Copolymer Nanodots. ACS Applied Nano Materials2020, 3, 1, 782-788

(59)Xiaoang Li, Jingying Zhai, and Xiaojiang Xie*, The Hofmeister Anion Effect on Ionophore‐based Ion‐selective Nanospheres Containing Solvatochromic Dyes. Electroanalysis2020, 32, 749-754

(58) Wenyue Gao, Elena Zdrachek, Xiaojiang Xie*, and Eric Bakker*, A Solid-State Reference Electrode Based on a Self-Referencing Pulstrode. Angewandte Chemie International Edition2020,59, 2294-2298.

(57) Wei Yang, Jingying Zhai, Xiaojiang Xie*, Rhodamine dye transfer from hydrogel to nanospheres for the chemical detection of potassium ions. Analyst, 2019, 144, 5617

(56) Qinghan Chen, Xiaoang Li, Renjie Wang, Fanxin Zeng, Jingying Zhai*, Xiaojiang Xie*, Rapid Equilibrated Colorimetric Detection of Protamine and Heparin: Recognition at the Nanoscale Liquid–Liquid Interface. Analytical Chemistry2019, 91, 10390

(55) Lu Wang, Stephanie Sadler, Tianchi Cao, Xiaojiang Xie, Joachim Moser Von Filseck, Eric Bakker*, Simplified Fabrication for Ion-Selective Optical Emulsion Sensor with Hydrophobic Solvatochromic Dye Transducer: A Cautionary Tale. Analytical Chemistry2019, 91, 8973

(54) Li Deng, Jingying Zhai, and Xiaojiang Xie*, A Chemiluminescent Ion Sensing Platform Based on Ionophores. Analytical Chemistry, 2019, 91, 8638

(53) Renjie Wang, Xinfeng Du, Jingying Zhai, and Xiaojiang Xie*, Distance and Color Change Based Hydrogel Sensor for Visual Quantitative Determination of Buffer Concentrations. ACS Sensors2019, 4, 1017

(52) Wenyue Gao, Stéphane Jeanneret, Dajing Yuan, Thomas Cherubini, Lu Wang, Xiaojiang Xie*, and Eric Bakker*, Electrogenerated Chemiluminescence for Chronopotentiometric Sensors. Analytical Chemistry2019, 91, 4889

(51) Fei Jia, Henrik Hupatz, Liu-Pan Yang, Hendrik V. Schröder, Dong-Hao Li, Shan Xin, Dieter Lentz, Felix Witte, Xiaojiang Xie, Beate Paulus, Christoph A. Schalley*, and Wei Jiang*, Naphthocage: A Flexible yet Extremely Strong Binder for Singly Charged Organic Cations. Journal of the American Chemical Society2019, 141 (10), 4468–4473

(50) Xinfeng Du, Manling Huang, Renjie Wang, Jingying Zhai, and Xiaojiang Xie*, A Rapid Point-of-Care Optical Ion Sensing Platform Based on Target-Induced Dye Release from Smart Hydrogels. Chemical Communications2019, 55, 1774

(49) Renjie Wang, Xinfeng Du, Yaotian Wu, Jingying Zhai, and Xiaojiang Xie*, Graphene Quantum Dots Integrated in Ionophore-Based Fluorescent Nanosensors for Na+ and K+. ACS Sensors2018, 3 (11), 2408

(48) Jingying Zhai, Liyuan Yang, Xinfeng Du, and Xiaojiang Xie*, Electrochemical-to-Optical Signal Transduction for Ion-Selective Electrodes with Light-Emitting Diodes. Analytical Chemistry2018, 90 (21), 12791

(47) Changyou Zhu, Manling Huang, Jialing Lan, Lung Wa Chung, Xin Li*, and Xiaojiang Xie*, Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode. ACS Omega2018, 3 (10), 12476

(46) Lu Wang, Xiaojiang Xie, Tianchi Cao, Jerôme Bosset, and Eric Bakker*,  Surface-Doped Polystyrene Microsensors Containing Lipophilic Solvatochromic Dye Transducers. Chemistry-A European Journal2018, 24, 1

(45) Xinfeng Du, Liyuan Yang, WenChang Hu, Renjie Wang, Jingying Zhai, and Xiaojiang Xie*, A Plasticizer-Free Miniaturized Optical Ion Sensing Platform with Ionophores and Silicon-Based Particles. Analytical Chemistry2018, 90 (9), 5818

(44) Coll Crespi, M.; Crespo, G. A.; Xie, X.; Touilloux, R.; Tercier-Waeber, M.; Bakker, E*., Agarose hydrogel containing immobilized pH buffer microemulsion without increasing permselectivity. Talanta, 2018, 177, 191

(43) Zhai, J.; Zhu, C.; Peng, X.; Xie, X.*, Ionophore-based Heterogeneous Calcium Optical Titration. Electroanalysis2018, 30 (4), 705

(42) Querard, J.; Zhang, R.; Kelemen, Z.; Plamont, M.-A.; Xie, X.; Chouket, R.; Roemgens, I.; Korepina, Y.; Albright, S.; Ipendey, E.; Volovitch, M.; Sladitschek, H. L.; Neveu, P.; Gissot, L.; Gautier, A. Faure, J.-D.; Croquette, V.; Le Sausx, T.*; Jullien, L.*, Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations. Nature Communications2017, 8 (1), 969

(41) Xinfeng Du, Xiaojiang Xie*, Non-Equilibrium Diffusion Controlled Ion-Selective Optical Sensor for Blood Potassium Determination. ACS Sensors2017, 2 (10), 1410

(40) Xinfeng Du, Changyou Zhu, Xiaojiang Xie*, Thermochromic Ion-Exchange Micelles Containing H+ Chromoionophores. Langmuir2017, 33 (23), 5910.

Before SUSTech:

(39) Zhai, J.; Xie, X.; Cherubini, T.; Bakker, E.* Ionophore-Based Titrimetric Detection of Alkali Metal Ions in Serum. ACS Sensors, 2017, 2 (4), 606.

(38) Xie, X.* Renovating the chromoionophores and detection modes in carrier-based ion-selective optical sensors. Analytical and Bioanalytical Chemistry, 2016, 408 (11), 2717.

(37) Xie, X.*; Zhai, J.; Jarolimova, Z.; Bakker, E.* Determination of pK(a) Values of Hydrophobic Colorimetric pH Sensitive Probes in Nanospheres. Analytical Chemistry, 2016, 88 (6), 3015.

(36) Wang, L.; Xie, X.; Zhai, J.; Bakker, E.* Reversible pH-independent optical potassium sensor with lipophilic solvatochromic dye transducer on surface modified microporous nylon. Chemical Communications, 2016, 52 (99), 14254.

(35) Xie, X.* Szilagyi, I; Zhai, J.; Wang, L.; Bakker, E.* Ion-Selective Optical Nanosensors Based on Solvatochromic Dyes of Different Lipophilicity: From Bulk Partitioning to Interfacial Accumulation. ACS Sensors, 2016, 1 (5), 516

(34) Zhai, J.; Xie, X.; Bakker, E.* Ion-selective optode nanospheres as heterogeneous indicator reagents in complexometric titrations. Analytical Chemistry, 2015, 87 (5), 2827.

(33) Zhai, J.; Xie, X.; Bakker, E.* Anion-exchange nanospheres as titration reagents for anionic analytes. Analytical Chemistry, 2015, 87 (16), 8347.

(32) Zhai, J.; Xie, X.; Bakker, E.* Solvatochromic Dyes as pH-Independent Indicators for Ionophore Nanosphere-Based Complexometric Titrations. Analytical Chemistry, 2015, 87 (24), 12318.

(31) Xie, X.*; Gutierrez, A.; Trofimov, V.; Szilagyi, I.; Soldati, T.; Bakker, E.* Charged solvatochromic dyes as signal transducers in pH independent fluorescent and colorimetric ion selective nanosensors. Analytical Chemistry, 2015, 87 (19), 9954.

(30) Xie, X.*; Gutierrez, A.; Trofimov, V.; Szilagyi, I.; Soldati, T.; Bakker, E.* Potassium Sensitive Optical Nanosensors Containing Voltage Sensitive Dyes. Chimia, 2015, 69 (4), 196.

(29) Xie, X.*; Bakker, E.* Ion selective optodes: from the bulk to the nanoscale. Analytical and Bioanalytical Chemistry, 2015, 407 (14), 3899.

(28) Xie, X.*; Bakker, E.* Determination of Effective Stability Constants of Ion-Carrier Complexes in Ion Selective Nanospheres with Charged Solvatochromic Dyes. Analytical Chemistry, 2015, 87 (22), 11587.

(27) Xie, X.; Crespo, G. A.; Mistlberger, G.; Bakker, E.* Photocurrent generation based on a light-driven proton pump in an artificial liquid membrane. Nature Chemistry, 2014, 6 (3), 202.

(26) Zhai, J.; Xie, X.; Bakker, E.* Ionophore-based ion-exchange emulsions as novel class of complexometric titration reagents. Chemical Communications, 2014, 50 (84), 12659.

(25) Xie, X.; Zhai, J.; Bakker, E.* Potentiometric response from ion-selective nanospheres with voltage-sensitive dyes. Journal of the American Chemical Society, 2014, 136 (47), 16465.

(24) Xie, X.*; Bakker, E.* Photoelectric conversion based on proton-coupled electron transfer reactions. Journal of the American Chemical Society, 2014, 136 (22), 7857.

(23) Zhai, J.; Xie, X.; Bakker, E.* Advancing Schwarzenbach’s Complexometry: Nano-scale Titration Reagents Based on Heterogeneous Reactions. Chimia, 2014, 68 (12), 899.

(22) Xie, X.; Zhai, J.; Crespo, G. A.; Bakker, E.* Ionophore-based ion-selective optical nanosensors operating in exhaustive sensing mode. Analytical Chemistry, 2014, 86 (17), 8770.

(21) Xie, X.; Zhai, J.; Bakker, E.* pH independent nano-optode sensors based on exhaustive ion-selective nanospheres. Analytical Chemistry, 2014, 86 (6), 2853.

(20) Xie, X.*; Crespo, G. A.; Zhai, J.; Szilagyi, I.; Bakker, E.* Potassium-selective optical microsensors based on surface modified polystyrene microspheres. Chemical Communications, 2014, 50 (35), 4592.

(19) Xie, X.*; Bakker, E.* Light-controlled reversible release and uptake of potassium ions from ion-exchanging nanospheres. ACS Applied Materials & Interfaces, 2014, 6 (4), 2666.

(18) Xie, X.*; Bakker, E.* Creating electrochemical gradients by light: from bio-inspired concepts to photoelectric conversion. Physical Chemistry Chemical Physics, 2014, 16 (37), 19781.

(17) Xie, X.; Mistlberger, G.; Bakker, E.* Visible light induced photoacid generation within plasticized PVC membranes for copper (II) ion extraction. Sensors and Actuators B: Chemical, 2014, 204, 807

(16) Jarolimova, Z.; Crespo, G. A.; Xie, X.; Ghahraman Afshar, M.; Pawlak, M.; Bakker, E.* Chronopotentiometric carbonate detection with all-solid-state ionophore-based electrodes. Analytical Chemistry, 2014, 86 (13), 6307.

(15) Eric Bakker, Mary-Lou Tercier-Waeber, Thomas Cherubini, Miquel Coll Crespi, Gastón A Crespo, Maria Cuartero, Majid Ghahraman Afshar, Zdenka Jarolimova, Stéphane Jeanneret, Sandrine Mongin, Bastien Néel, Nadezda Pankratova, Romain Touilloux, Xiaojiang Xie, Jingying Zhai, Environmental Sensing of Aquatic Systems at the University of Geneva. Chimia, 2014, 68 (11), 772.

(14) Afshar, M. G.; Crespo, G. A.; Xie, X.; Bakker, E.* Direct alkalinity detection with ion-selective chronopotentiometry. Analytical Chemistry, 2014, 86 (13), 6461.

(13) Xie, X.*; Bakker, E.* Detecting and manipulating ions. Q&More (Spotlight on: Bioanalytics | Ion Sensors ) 2014, 02.14

(12) Bakker, E*, and Xie, X.*, Shrinking Ion-selective Sensors for Success. The Analytical Scientist, 2014, 09/23/2014

(11) Xie, X.; Mistlberger, G.; Bakker, E.* Ultrasmall fluorescent ion-exchanging nanospheres containing selective ionophores. Analytical Chemistry, 2013, 85, 9932

(10) Xie, X.; Crespo, G. A.; Bakker, E.* Oxazinoindolines as fluorescent H+ turn-on chromoionophores for optical and electrochemical ion sensors. Analytical Chemistry, 2013, 85 (15), 7434

(9) Xie, X.; Bakker, E.* Non-Severinghaus potentiometric dissolved CO2 sensor with improved characteristics. Analytical Chemistry, 2013, 85 (3), 1332

(8) Mistlberger, G.*; Xie, X.; Pawlak, M.; Crespo, G. A.; Bakker, E.* Photoresponsive ion extraction/release systems: dynamic ion optodes for calcium and sodium based on photochromic spiropyran. Analytical Chemistry, 2013, 85 (5), 2983

(7) Eric Bakker*, Ewa Grygolowicz-Pawlak, Xiaojiang Xie, Günter Mistlberger, Gaston Crespo, Majid Afshar, Bastien Néel, Alexey Shvarev, Modern chemical ion sensor concepts based on electrochemically and optically triggered phase transfer. Analytical Chemistry, 2012, 66, 479

(6) Xie, X.; Pawlak, M.; Tercier-Waeber, M. L.; Bakker, E.* Direct optical carbon dioxide sensing based on a polymeric film doped with a selective molecular tweezer-type ionophore. Analytical Chemistry, 2012, 84 (7), 3163

(5) Xie, X.; Mistlberger, G.; Bakker, E.* Reversible photodynamic chloride-selective sensor based on photochromic spiropyran. Journal of the American Chemical Society, 2012, 134 (41), 16929

(4) Mistlberger, G.; Crespo, G. A.; Xie, X.; Bakker, E.* Photodynamic ion sensor systems with spiropyran: photoactivated acidity changes in plasticized poly(vinyl chloride). Chemical Communications, 2012, 48 (45), 5662

(3) Bakker, E.*; Crespo, G.; Grygolowicz-Pawlak, E.; Mistlberger, G.; Pawlak, M.; Xie, X. Advancing membrane electrodes and optical ion sensors. Chimia, 2011, 65 (3), 141

(2) Xie, X.; Qin, Y.* A dual functional near infrared fluorescent probe based on the bodipy fluorophores for selective detection of copper and aluminum ions. Sensors and Actuators B: Chemical, 2011, 156 (1), 213

(1) Xie, X.; Li, X.; Ge, Y.; Qin, Y.*; Chen, H.-Y. Rhodamine-based ratiometric fluorescent ion-selective bulk optodes. Sensors and Actuators B: Chemical, 2010, 151 (1), 71

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