Associate Professor |School of Life Sciences, Department of Biology

Zhiyi Wei, PhD

Associate Professor, Department of Biology

Biochemistry, Biophysics, Structural Biology, and Neurobiology

ORCID iD: 0000-0002-4446-6502

Personal Profile

Dr. Zhiyi Wei was attracted by the uniqueness of structural biology in understanding biology during his Ph.D. study. After his postdoctoral training at University of Washington, he joined the Hong Kong UST as a Research Assistant Professor. Currently, he is an Associate Professor at Southern University of Science and Technology. His research focus on decoding the mystery of how life is built up via dynamic interactions between proteins and between protein and other biomolecules at atomic level. We use structural biology approach, combining with biochemistry and cell biology approaches, to dissect the structures and regulatory mechanisms of key protein complexes underlying various cellular processes, especially membrane-related events in neuronal development. Since 2009, he has published more than 20 high impact research papers in international journals, including NatureScience, Cell, Molecular Cell, and PNAS.


Research Interests
◆ Molecular mechanism of neuronal development and related diseases
◆ Assembly mechanisms of membrane microdomains
◆ Intracellular trafficking of membrane compartments
◆ Transmembrane signalings
◆ Protein machines


Professional Experience
◆ 2013 – present, Associate Professor, Department of Biology, Southern University of Science and Technology of China
◆ 2009 – 2013, Research Associate Professor, Division of Life Science, Hong Kong University of Science and Technology
◆ 2007 – 2009, Research Fellow, School of Medicine, University of Washington


Educational Background
◆ 2007, Ph.D., Biochemistry & Molecular Biology, University of Science and Technology of China
◆ 2002, B.S., Biology, University of Science and Technology of China


Honors & Awards
◆ 2019 SUSTech Presidential Early Career Award for Excellent in Research
◆ 2019 High-Level Professional in Shenzhen, National Level
◆ 2016 Special Support for Technology Top-Notch Innovative Young Talents of Guangdong Province
◆ 2016 SUSTech Excellent Research Award
◆ 2014 Shenzhen Oversea High-Caliber Personnel, Level B
◆ 2011-2013 Tin Ka Ping Fellowship, Tin Ka Ping Foundation
◆ 2007 Outstanding Graduate of University of Science and Technology of China


◆ Molecular mechanism of neuronal development and related diseases

◆ Assembly mechanisms of membrane microdomains

◆ Intracellular transport mechanisms

◆ Protein machinery

Publications Read More

  1. Liang M, Jin G, Xie X, Zhang W, Li K, Niu F, Yu C#, Wei Z#.Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep. 34:108901. (2021)
  2. Yang H, Lin L, Sun K, Zhang T, Chen W, Li L, Xie Y, Wu C, Wei Z, Yu C.Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics. eLife. 10.(2021)
  3. Niu F, Sun K, Wei W, Yu C#, Wei Z#. F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis. Sci Adv. 6. (2020)
  4. Xie X, Luo L, Liang M, Zhang W, Zhang T, Yu C, Wei Z#. Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity. Nat Commun. 11:169. (2020)
  5. Tang K#, Li Y, Yu C, Wei Z#. Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2. J Biol Chem. 294:5896-5906. (2019)
  6. Wang L, Yao D, Deepak RNVK, Liu H, Xiao Q, Fan H, Gong W, Wei Z#, Zhang C#. Structures of the human PGD2 receptor CRTH2 reveal novel mechanisms for ligand recognition. Mol Cell. 72:48-59. (2018)
  7. Li H*, Deng Y*, Sun K, Yang H, Liu J, Wang M, Zhang Z, Lin J, Wu C#, Wei Z#, Yu C#. Structural basis of kindlin-mediated integrin recognition and activation. Proc Natl Acad Sci USA. 114:9349-9354. (2017)
  8. Zhao H, Sheng G, Wang J, Wang M, Bunkoczi G, Gong W, Wei Z#, Wang Y#. Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli. Nature. 515:147-150. (2014)

News More

  • SUSTech researchers reveal molecular mechanisms to understand how cells communicate with surrounding environments

  • Congratulation on Graduation

  • SUSTech researchers reveal a novel mechanism of intracellular logistics


Lab members Read More

Join us

Currently, two postdoctoral positions are avaliable. Applicants should hold PhD degree with strong biochemistry, structural biology, or cellular neuroscience background. Please send your CV and two reference letters to

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RM211, Biology Hall

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