ASSISTANT PROFESSOR School of Medicine, Department of Medical Neuroscience
Zilong Wang, Ph.D., Assistant Professor in the School of medicine, Southern University of Science and Technology. Dr. Wang graduated from Lanzhou University in 2011. He received his Ph.D from Lanzhou University in 2017. During the graduate study, he worked at Duke University as a visiting graduate student for 1 year. He had his postdoctoral training at Duke University. Dr. Wang’s research is focused on the molecular and cellular mechanism of pathological pain and itch, development of novel candidate analgesics and antipruritic. He has 34 publications, 10 of them are first author or co-corresponding author publications, including “Science Translational Medicine”、“Brain”、“Gastroenterology”、“Neuron” et al.. Dr. Wang has applied 7 patents in China and 3 PCTs and 1 patent in the United States.
Wang Zilong is an assistant professor and doctoral supervisor at the School of Medicine of Southern University of Science and Technology. In 2011, he graduated from the biology talent training base of Lanzhou University. In 2017, he received a Ph.D. degree in joint training from Lanzhou University-Duke University. Later, he conducted post-doctoral research at Duke University. Wang Zilong has long been committed to the research of the molecular cells and neural mechanisms of pain and itching, as well as the research and development of analgesic or antipruritic drugs. He has published 33 SCI papers in related fields, including 10 papers as the first author or corresponding author, including high-level journals such as "Science Translational Medicine", "Brain", "Gastroenterology", and "Neuron". In addition, as the main inventor, I have applied for 7 Chinese national invention patents and 5 have been authorized; I have applied for 3 PCT international patents and 1 US patent.
The research direction of the laboratory mainly involves "pain", "itching", and "development of new analgesic or antipruritic drugs". The main research directions include:
(1) The neural mechanism of pain and itching and the discovery of new targets;
(2) Immune-neural interaction;
(3) Research on the cellular and molecular mechanisms of pathological pain and research and development of new drugs and new technologies for clinical treatment;
(4) Cellular molecular and neural circuit mechanisms of opioid analgesia and its side effects;
(5) Research and development of analgesic or antipruritic drugs.
2007.09 – 2011.06, Bachelor of Lanzhou University, major in biological sciences
2011.09 – 2017.06, Lanzhou University-Duke University Joint Ph.D. major in Biochemistry and Molecular Biology
2017.10-2021.01, Duke University School of Medicine, Postdoctoral Researcher
2021.03-now, Southern University of Science and Technology School of Medicine, assistant professor and doctoral supervisor
Awards and honors
2015 National Scholarship
2017 Outstanding Graduate of Lanzhou University
Representative articles in recent years
1. Zilong Wang1, Changyu Jiang1, Qianru He, Megumi Matsuda, Qingjian Han, Kaiyuan Wang, Sangsu Bang, Huiping Ding, Mei-Chuan Ko, Ru-Rong Ji*. Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates. Science Translational Medicine. 2020; 12 (531): eaaw6471 (1: authors contributed equally to this work)
2. Zilong Wang1*, Changyu Jiang1, Hongyu Yao, Ouyang Chen, Sreya Rahman, Yun Gu, Yul Huh, & Ru-Rong Ji*. Central opioid receptors mediate morphine-induced itch and chronic itch. Brain. 2021 Mar 3;144 (2):665-681(1: authors contributed equally to this work)
3. Zilong Wang, Christopher R Donnelly, Ru-Rong Ji*. Scratching after Stroking and Poking: A Spinal Circuit Underlying Mechanical Itch. Neuron. 2019; 103: 952-954
4. Yong Chen1*, Zilong Wang1, Michele Yeo, Qiao-Juan Zhang, Ana E. López-Romero, Alan E. Medina-Arellano, Hui-Ping Ding, Xin Zhang, Qian Zeng, Sara L. Morales-Lázaro, Carlene Moore, Ying-Ai Jin, Johannes Morstein, Andrey Bortsov, Marcin Krawczyk, Frank Lammert, Anna Mae Diehl, Piotr Milkiewicz, Andreas E. Kremer, Jennifer Y. Zhang, Andrea Nackley, Tony E. Reeves, Mei-Chuan Ko, Ru -Rong Ji, Tamara Rosenbaum, Wolfgang Liedtke*. Epithelia-sensory neuron crosstalk underlies cholestatic itch induced by lysophosphatidylcholine. Gastroenterology. Accepted (1: authors contributed equally to this work)
5. Zilong Wang, Jia-Xin Pan, Jing-Jing Song, Hong-Hai Tang, Hong-Ping Yu, Xu-Hui Li, Ning Li, Ting Zhang, Run Zhang, Meng-Na Zhang, Biao Xu, Quan Fang* , Rui Wang*. Structure-based optimization of multifunctional agonists for opioid and neuropeptide FF receptors with potent non-tolerance forming analgesic activities. Journal of Medicinal Chemistry. 2016, 59 (22), 10198-10208.
6. Sharat Chandra1, Zilong Wang1, Xueshu Tao, Ouyang Chen, Xin Luo, Ru-Rong Ji, Andrey V. Bortsov. Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. Anesthesiology. 2020; In Press. (1: authors contributed equally to this work)
7. Zilong Wang, Biao Xu, Changyu Jiang, Ting Zhang, Mengna Zhang, Ning Li, Qinqin Zhang, Kangtai Xu, Dan Chen, Jian Xiao, Quan Fang*. Spinal DN-9, a peptidic multifunctional opioid/neuropeptide FF agonist produced potent nontolerance forming analgesia with limited side effects. Journal of Pain, 2020, 21(3–4), 477−493
8. Zilong Wang1, Ning Li1, Pei Wang, Hong-hai Tang, Zheng-lan Han, Jing-jing Song, Xu-hui Li, Hong-ping Yu, Ting Zhang, Run Zhang, Biao Xu, Meng-na Zhang, Quan Fang*, Rui Wang*. Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance. Neuropharmacology. 2016; 108: 364-372 (1: authors contributed equally to this work)
9. Yang Suo, Zilong Wang, Lejla Zubcevic, Allen L Hsu, Qianru He, Mario J Borgnia, Ru-Rong Ji, Seok-Yong Lee. Structural insights into electrophile irritant sensing by the human TRPA1 channel. Neuron, 2020; 105 ( 5), 882-894.e5
10. Christopher R Donnelly, Changyu Jiang, Amanda S Andriessen, Kaiyuan Wang, Zilong Wang, Huiping Ding, Junli Zhao, Xin Luo, Michael S Lee, Yu L Lei, William Maixner, Mei-Chuan Ko, Ru-Rong Ji. STING controls nociception via type I interferon signaling in sensory neurons. Nature, 2021 Mar;591(7849):275-280.
Our specific research interests are understanding mechanisms critical for pain and itch and identifying new targets that modulate pain and itch sensations. The long-term goal is developing powerful analgesics and anti-pruritics with limited side effects.
（1）Molecular and cellular mechanisms of opioid receptor signaling in health and disease;
（2）Development of novel candidate analgesics and antipruritics.
（3）Identify new targets for pain and itch treatments;
（4）Neuro-immune interaction in pain and itch;
（5）Molecular and cellular mechanism of pathological pain;
Physiology and Pathophysiology (Undergraduate)
Publications Read More
Lab members Read More
Recruiting 2 Postdoctoral Researchers
Introduction to the research group
Wang Zilong, Assistant Professor (Tenure-track A/P), Southern University of Science and Technology School of Medicine, independent project leader and doctoral supervisor. Received a PhD degree from Lanzhou University in 2017. Conducted postdoctoral research at Duke University from 2017 to 2021. Our research group has long been committed to the research of the molecular cells and neural mechanisms of pain and itching, as well as the research and development of analgesic or antipruritic drugs. Related results have been published in high-level magazines such as "Science Translational Medicine", "Brain", "Gastroenterology", and "Neuron".
The research direction of the research group includes: (1) the discovery of the neural mechanism and new targets of pain and itch; (2) the immune-nerve interaction related to pain and itch; (3) cancerous, diabetic, chemotherapy, nerve damage Research on the cellular and molecular mechanisms of pathological pain and the development of new technologies for clinical treatments; (4) Cellular and molecular mechanisms of opioid analgesia and its side effects and neural circuit mechanisms. (5) Research and development of analgesic or antipruritic drugs related to ion channels.
The applicant's main research field and academic background requirements
Neurobiology, neuropharmacology, neuroimmunology; those with pain or itch research experience or research experience in animal behavior, patch clamp electrophysiology, computer-aided drug design, etc. are preferred.
Basic requirements 1. Have obtained a full-time doctorate degree in related majors, and the time to obtain a doctorate degree generally does not exceed 2 years. Possess solid professional knowledge, research skills and the ability to independently conduct scientific research, as well as excellent scientific research training and practice records. 2. Love science and be interested in neuroscience research or neurological disease drugs, and have a good team spirit. 3. Have good English writing skills and Chinese and English communication skills.
1. The post-doctoral employment period is two years, with an annual salary of 330,000 yuan, including Guangdong Province living allowance of 150,000 yuan and Shenzhen living allowance of 60,000 yuan, and participating in social insurance and housing provident fund in accordance with the relevant regulations of Shenzhen. Post-doctoral welfare fees are paid in accordance with the school’s faculty and staff standards. 2. Particularly outstanding candidates can apply for the principal's outstanding postdoc, with an annual salary of more than 410,000 yuan (including subsidies from Guangdong Province and Shenzhen). 3. During the station, you can rely on the school to apply for Shenzhen public rental housing. Postdoctoral fellows who do not rely on the school to use Shenzhen public rental housing can enjoy a housing subsidy of 2,800 yuan/month before tax for two years. 4. Possess an excellent working environment and opportunities for cooperation and exchanges at home and abroad. Post-doctoral fellows will enjoy a total of 25,000 academic exchange funding for two years during their stay at the station.
Detailed personal resume, including study, work and scientific research experience, main scientific research results (papers, patents, treatises, etc.), and other materials that can prove work ability. Provide the names and valid contact information of at least 2 recommenders. Applicants are requested to integrate the above materials into a single PDF file and send it.
Candidates please integrate the above application materials into a single PDF and send it to firstname.lastname@example.org. After receiving the email, we will reply as soon as possible and invite an interview. This recruitment announcement is valid for a long time, and we look forward to joining!