Department of Chemistry   Research Group

Dr. Jie Wang joined in Southern University of Science and Technology as an assistant professor (PI) in June 2020 and the research of Jie’s gourp mainly focus on the bioorthogonal chemistry, genetic code expansion and directed evolution of enzymes.

Jie Wang obtained his B.S. of chemistry from Wuhan University (WHU) at 2012, and then he got the Ph.D degree from Peking University (PKU). In the past ten years, Jie Wang worked at the Prof. Aiwen Lei group (WHU 2009-2012), Prof. Peng Chen gourp (PKU,2012-2020) and Prof. Chu Wang group (PKU, 2018-2020) for the study of organic chemistry, protein chemistry, bioorthogonal chemistry, genetic code expansion and chemical proteomics. Dr. Jie Wang developed a siries of chemical biology tools for the precise control of protein functions in living systems and published 4 papers as first authors in international refereed journals, including Nature,J Am Chem Soc and Angew Chem In Ed.

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Bioorthogonal chemistry

Directed evolution of enzyme

Genetic code expansion

Protein chemistry

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Selected publications:

1. Jie Wang#, Yuan Liu#, Yanjun Liu#, Siqi Zheng, Xin Wang, Jingyi Zhao, Fan Yang, Gong Zhang, Chu Wang*, Peng Chen*. Time-resolved protein activation by proximal decaging in living systems. Nature, 2019, 569, 509–513.

2. Jie Wang, Siqi Zheng, Yanjun Liu, Zhaoyue Zhang, Zhi Lin, Jiaofeng Li, Gong Zhang, Xin Wang, Jie Li, Peng R. Chen*. Palladium-triggered chemical rescue of intracellular proteins via genetically encoded allene-caged tyrosine. J. Am. Chem. Soc. 2016, 138(46), 15118-21.

3. Jie Wang#, Bo Cheng#, Jie Li#, Zhaoyue Zhang, Weiyao Hong, Xing Chen*, Peng R. Chen*. Chemically remodeling of cell-surface sialic acids by using the palladium-triggered bioorthogonal elimination reactions. Angew. Chem. Int. Ed., 2015, 54 (18), 5364-5368.

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