Leilei Tian, Ph.D.

Associate Professor Department of Materials Science and Engineering


2003-2008 Jilin University (PhD, Polymer Chemistry and Physics)

1999-2003 Jilin University (Bachelor, Chemical Engineering and Technology)

Research experiences

2015-present: South University of Science and Technology of China Position: associate professor

2014-2015: The University of Chicago Position: Research Fellow

2011-2014: The University of Chicago Position: Post-doctoral Scholar

2009-2010: Clemson University (CU) Position: Post-doctoral Scholar

2008-2009: University of South Carolina (USC) Position: Post-doctoral Scholar

Honours and Awards

Shenzhen Peacock Award, Shenzhen Municipality China

Personal Profile


•Composite, hybrid intelligent materials based on bio-macromolecules: Our project focuses on the development of novel nucleic acid nano-biotechnology. Compared with synthetic polymers, nucleic acids exhibit many unique properties, including its biological function, biocompatibility, and molecular recognition capacity. We engage in developing DNA composite/hybrid materials, which will have interesting applications in biosensors and biomedicines.

•Chemical and bio-sensing applications of organic optoelectronic materials: To achieve ultrasensitive detection of small molecules or biomarkers, we develop new optoelectronic material systems by designing and adjusting their intermolecular forces.

•Developing new strategies of signal amplifications for the highly sensitive detection of cancer markers.


•Physical Chemistry, sophomore college students, SUSTC

•Materials Chemistry, junior college students, SUSTC

Publications Read More


(1)Chao, Z. C.; Lu, H. W.; Xiao, F.; Shao, C.; Wei, Z. X.; Yu, J. T.; Zhang, X. D.; Li, L.; Tian, L. L.* “Robust and Tumor-Environment-Activated DNA Crosslinker Driving Nanoparticle Accumulation for Enhanced Therapeutics” CCS Chem. 2020, 2, 349–361.

(2)Xiao, F.; Li, L.; Chao, Z. C.; Shao, C.; Chen, Z.; Wei, Z. X.; Lu, J. X.; Huang, Y. S.; Li, L. Q.; Liu, Q.; Liang, Y. Y.; Tian, L. L.* “Organic Spherical Nucleic Acids for the Transport of a NIR‐II‐Emitting Dye Across the Blood–Brain Barrier.” Angew. Chemie 2020, 59, 2–11.

(3)Chen, Z.; Lu, J. X.; Xiao, F.; Huang, Y. S.; Zhang, X. J.*; Tian, L. L.* “A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission” Chem. Commun. 2020, 56, 1501-1504.

(4)Wang, M. J.; Han, L.; Zhu, Y. L.; Qi, R.; Tian, L. L.*; He, F.* “Formation of Hierarchical Architectures with Dimensional and Morphological Control in the Self-Assembly of Conjugated Block Copolymers” Small Methods 2020, 4, 1900470.

(5)Shao, C.; Xiao, F.; Guo, H.; Yu, J. T.; Jin, D.; Wu, C. F.; Xi, L.*; Tian, L. L.* “Utilizing Polymer Micelle to Control Dye J-aggregation and Enhance Its Theranostic Capability” iScience 2019, 22, 229–239.

(6)Li, J.; Yu, J. T.; Huang, Y. S.; Zhao, H. R.; Tian, L. L.* “Highly Stable and Multiemissive Silver Nanoclusters Synthesized in Situ in a DNA Hydrogel and Their Application for Hydroxyl Radical Sensing” ACS Appl. Mater. Interfaces. 2018, 10, 26075−26083.

(7)Zhao, H. R.; Yuan, X. X.; Yu, J. T.; Huang, Y. S.; Shao, C.; Xiao, F.; Li, L.; Li, Y.; Tian, L. L.* “Magnesium Stabilized Multifunctional DNA Nanoparticles for Tumor-Targeted and pH-Responsive Drug Delivery” ACS Appl. Mater. & Interfaces. 2018, 10, 15418-15427.

(8)Yu, J. T.; He, S. H.; Shao, C.; Zhao, H. R.; Li, J.; Tian, L. L.* “A Common Anchor Facilitated GO-DNA Nano-system for Multiplex MicroRNA Analysis in Live Cells” Nanoscale. 2018, 10, 7067-7076.

(9)Shao, C.; Liang, J.; He, S. H.; Luan, T. Q.; Yu, J. T.; Zhao, H. R.; Xu, J. Y.; Tian, L. L.* “pH-Responsive Graphene Oxide-DNA Nano-System for Living Cell Imaging and Detection” Anal. Chem. 2017, 89, 5445-5452.

(10)Huang, Y. S.; Xu, W. L.; Liu, G. Y.; Tian, L. L.* “A Pure DNA Hydrogel with Stable Catalytic Ability Produced by One-step Rolling Circle Amplification”, Chem. Commun. 2017, 53, 3038.

(11)Tian, L. L.; Cronin, T. M.; Weizmann, Y.* “Enhancing-effect of Gold Nanoparticles on DNA Strand Displacement Amplifications and Their Application to an Isothermal Telomerase Assay”, Chem. Sci., 2014, 5, 4153 (Front Cover).

(12)Tian, L. L.; Weizmann, Y.* “Real-Time Detection of Telomerase Activity Using the Exponential Isothermal Amplification of Telomere Repeat Assay”, J. Am. Chem. Soc., 2013, 135, 1661.

News More

  • Congratulations! The research group published paper in the journal Chemical Communications

  • Congratulations! The research group published paper in the journal Advanced Science

  • 祝贺2018级硕士生金东圆满毕业


Lab members Read More

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South University of Science and Technology of China,Faculty Research Building 2, Room 407

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