Associate Professor Department of Biology

Dr. Sun obtained her Ph.D. degree from Hong Kong University of Science and Technology. At 2012, she joined Southern University of science and technology.

Personal Profile

Research

Cell-extracellular matrix (ECM) interactions are critically involved in multiple human diseases development and progression. The focal adhesion complexes consisting of integrin-linked kinase (ILK), PINCH and parvin (IPP complex) and Kindlin-2-migfillin complex that plays important roles in controlling integrin-mediated cell-ECM adhesion and signaling. The goal of my laboratory is to understand the function and molecular mechanism of these focal adhesion proteins in human diseases (particularly in cancer and glomerular disease) progression and to identify a number of novel focal adhesion proteins mediated signaling axis that may serve as useful targets for therapeutic control of cancer or glomerular disease.


Teaching

1.Introduction to Human Health and Diseases

2.Microbiology

3.Microbiology Lab

4.Frontier in Life Sciences Seminar and Journal Club


Publications Read More

1.Liu J#, Liu Z#, Chen K#, Chen W, Fang X, Li M, Zhou X, Ding N, Lei H, Guo C, Qian T, Wang Y, Liu L, Chen Y, Zhao H, Sun Y*, Deng Y*, Wu C*. (2020). Kindlin-2 promotes rear focal adhesion disassembly and directional persistence in cell migration. J Cell Sci. Dec 4. doi: 10.1242/jcs.244616.

2.Wang M, Liu J, Tu Y, Zhao Z, Qu J, Chen K, Chen Y, Sun Y, Zhao H, Deng Y*, Wu C*. (2020). RSU-1 interaction with prohibitin-2 links cell–extracellular matrix detachment to downregulation of ERK signaling. J Biol Chem. Nov 22; doi: 10.1074/jbc.RA120.014413.

3.Qian T#, Liu C#, Ding Y, Guo C, Cai R, Wang X, Wang R, Zhang K, Zhou L, Deng Y, Wu C*, Sun Y*. (2020). PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis. Oncogene. Mar;39(10):2069-2087

4.Sun Y*#, Ding Y#, Guo C#, Liu C, Ma P, Ma S, Wang Z, Liu J, Qian T, Ma L, Deng Y, Wu C*. (2019). α-parvin promotes breast cancer progression and metastasis through interaction with G3BP2 and regulation of TWIST1 signaling. Oncogene. Jun;38 (24):4856-4874.

5.Guo L*, Cui C, Zhang K, Wang J, Wang Y, Lu Y, Chen K, Yuan J, Xiao G, Tang B, Sun Y*, Wu C*. (2019). Kindlin-2 links mechano-environment to proline synthesis and tumor growth. Nat Commun. 10(1):845.

6.Chu B#, He A#, Tian Y, He W, Chen P, Hu J, Xu R, Zhou W, Zhang M, Yang P, Sun Y*, Li P*, Hunter T, Tian R*. (2018). Photoaffinity engineered protein scaffold for systematically exploring native phosphotyrosine signaling complexes in tumor samples. Proc Natl Acad Sci U S A. 115(38):E8863-E8872.

7.Sun Y*#, Guo C#, Ma P, Lai Y, Yang F, Cai J, Sheng Y, Cheng Z, Tian R, Deng Y, Xiao G*, Wu C*. (2017). Kindlin-2 association with Rho GDP-Dissociation Inhibitor α suppresses Rac1 activation and podocyte injury. J Am Soc Nephrol. 28 (12): 3545-3562.

8.Hu W#, Yu X#, Liu Z#, Sun Y, Chen X, Yang X, Li X, Lam W, Duan Y, Cao X, Steller H, Liu K, Huang P*. (2017). The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multipleadenylyl cyclase isoforms. Elife. 28;6. pii: e28021.

9.Sun Y*, Huang P*. (2016). Adenosine A2B receptor: from cell biology to human diseases. Front Chem. 4:37. (invited review)

10.Sun Y#, Hu W#, Yu X, Liu Z, Tarran R, Ravid K, Huang P*. (2016). Actinin-1 binds to the C-terminus of A2B adenosine receptor and enhances its cell surface expression. Biochem J. 473(14):2179-86.

11.Sun Y, Duan Y, Eisenstein A, Hu W, Quintana A, Lam WK, Wang Y, Wu Z, Ravid, K, Huang P*. (2012). A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. J Cell Sci. 125(Pt 19):4507-17.

12.Sun Y# , Wu F# , Sun F, and Huang P*. (2008). Adenosine promotes IL-6 release in airway epithelia. J Immunol. 180(6):4173-81.

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Contact Address

Office Phone

+86-755-88018412

Email

suny@sustech.edu.cn

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