professor School of Medicine
Professor, Department of Biochemistry, School of medicine, Southern University of science and technology. He was a professor at the University of Texas Health Center, focusing on the mechanism and function of protein homeostasis regulation. He trained more than 40 students, doctors and postdoctors. The research has long been supported by NIH, cancer society, Department of defense and several private foundations. As a number of international fund review experts and editorial board members of academic journals. Our research has been published in many international journals, including nature, PNAs, JCB, JBC, BMC, cancer research, scientific reports, etc.
Protein homeostasis plays an important role in health and disease function. Protein homeostasis and quality control are crucial to the normal life of cells. Abnormal protein homeostasis leads to a variety of diseases, including tumors and neurodegenerative diseases. The mechanism of protein degradation induced by protein modification and ubiquitination was studied by yeast and human cell system. On this basis, we will study the regulation mechanism of protein homeostasis and its role in a number of diseases, including cancer and senile neurological diseases. The specific research directions are as follows:
1) Large scale screening of genes related to protein homeostasis in yeast.
2) How protein ubiquitination regulates various intracellular pathways (including DNA repair, cell cycle regulation, autophagy, etc.). One of the most important functions of protein ubiquitination is to help cells adapt to new challenges and changes, such as DNA damage, cell cycle changes and various stresses. We have been paying attention to the contribution of protein cleavage in these aspects. We have some experience and foundation, and will also do screening to determine its function and impact.
3) Protein ubiquitination technology application, the development of new cancer drugs and treatment methods. We are already designing new methods to rapidly degrade proteins that cause human diseases to develop their therapeutic effects.
4) How can ubiquitination participate in the development of senile neurological diseases by regulating the quality of proteins. We have a certain foundation in this area, and have a deep research on the cleaved proteins with folding errors.