Assistant Professor |School of Life Sciences, Department of Biology

Our group is mainly focused on RNA-based regulation of gene expression in B lymphocytes. We would like to know how RNA processing and modifications are linked to modulating B cell development and differentiation.

Personal Profile

WORK EXPERIENCE:
2016-present, Assistant Professor, Department of Biology, SUSTech
2015-2016, Associate Staff Scientist, Bioprocessing Technology Institute, Singapore
2009-2015, Research Scientist, Bioprocessing Technology Institute, Singapore

EDUCATION:
2002-2009, Ph.D. (Microbiology), Fudan University, China
1997-2001, B.Sc. (Microbiology), Huazhong Agricultural University, China

Research

1. B Cell Development

2. Humoral Immune Response


Teaching

1. Microbiology (undergraduate)

2. Cellular and Molecular Immunology (postgraduate)


Publications Read More

     #co-first author,*corresponding author

  1. Tan AH#, Tso GHW#, Zhang B#, Teo PY#, Ou X#, Ng SW, Wong AXF, Tan SJX, Sanny A, Kim SS, Lee AP, Xu S, Lam KP*. TACI Constrains TH17 Pathogenicity and Protects against Gut Inflammation. iScience. 2020 Oct 22;23(11):101707.
  2. Xu S, Huo J, Huang Y, Aw M, Chen S, Mak S, Yip LY, Ho YS, Ng SW, Tan AH, Lee A, Ou X, Lam KP*. von Hippel-Lindau Protein Maintains Metabolic Balance to Regulate the Survival of Naive B Lymphocytes. iScience. 2019 Jul 26;17:379-392.
  3. Ou X*, Huo J, Huang Y, Li YF, Xu S*, Lam KP*. Transcription factor YY1 is essential for iNKT cell development. Cellular & Molecular Immunology. 2019 Jun;16(6):547-556.
  4. Li YF, Xu S, Huang Y, Ou X, Lam KP*. Tyrosine kinase c-Abl regulates the survival of plasma cells. Scientific Reports. 2017 Jan 6;7:40133.
  5. Li YF#, Ou X#, Xu S, Jin ZB, Iwai N, Lam KP*. Loss of miR-182 affects B-cell extrafollicular antibody response. Immunology 2016, 148(2):140-9.
  6. Xu S#, Ou X#, Huo J, Lim K, Huang Y, Chee S, Lam KP*. Mir-17-92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c. Nature Communications 2015, 6:6764.
  7. Li YF, Lee KG, Ou X, Lam KP*. Bruton’s tyrosine kinase and protein kinase C µ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cells. PLoS One 2014, 9(8):e105420.
  8. Ou X, Xu S, Li YF, Lam KP*. Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands. PNAS 2014, 111(31):11431-6.
  9. Li YF, Xu S, Ou X, Lam KP*. Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool. Nature Communications 2014, 5:4273.
  10. Ou X, Xu S, Lam KP*. Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival. PNAS 2012, 109(38):15401-6.
  11. Zhang X, Bao Y, Shi X, Ou X, Zhou P*, Ding X*. Efficient transposition of IS204-derived plasmids in Streptomyces coelicolor. Journal of Microbiological Methods 2012, 88(1):67-72.
  12. Zhang L, Wang L, Wang J, Ou X, Zhao G*, Ding X*. DNA cleavage is independent of synapsis during Streptomyces phage phiBT1 integrase-mediated site-specific recombination. Journal of Molecular Cell Biology 2010, 2(5):264-75.
  13. Ou X, Zhang B, Zhang L, Zhao G*, Ding X*. Characterization of rrdA, a TetR family protein gene involved in the regulation of secondary metabolism in Streptomyces coelicolor. Applied and Environmental Microbiology 2009, 75(7):2158-65.
  14. Ou X, Zhang B, Zhang L, Dong K, Liu C, Zhao G*, Ding X*. SarA influences the sporulation and secondary metabolism in Streptomyces coelicolor M145. Acta Biochimica et Biophysica Sinica 2008, 40(10):877-82.
  15. Zhang L, Ou X, Zhao G*, Ding X*. Highly efficient in vitro site-specific recombination system based on streptomyces phage phiBT1 integrase. Journal of Bacteriology 2008, 190(19):6392-7.

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Join us

Open Postdoctoral Position

 

The Ou laboratory has an opening for a highly motivated, self-driven postdoctoral fellow with background knowledge in immunology.  The successful candidate will conduct research projects focused on studying the roles of RNA splicing and modifications in B cell development and differentiaiton.

 
Required Qualifications: 
  • -The successful candidate must have a PhD or MD/PhD in which s/he has gained knowledge in cell and molecular biology, developmental biology, immunology, or cancer biology.
  • -Specific skills and personal attributes required include: excellent writing and presentation skills, high energy multi-tasker, supremely organized with exquisite attention to detail, ability to work independently, strong expertise with molecular and cellular biology.
  • -Collaborative team spirit, strong communication skills, positive attitude and adherence to highest ethical principles are necessary to be considered.
 
Required Application Materials: 
  • -Updated CV
  • -Complete contact information for three references
  • -Short cover letter describing their past research experience, career goals and a statement of future research interest (1 page)

 

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Contact Us

Contact Address

1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong, China 518055

Office Phone

0755-88018402

Email

ouxj@sustech.edu.cn

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