Assistant Professor |School of Life Sciences, Department of Biology

Our group is mainly focused on RNA-based regulation of gene expression in B lymphocytes. We would like to know how RNA processing and modifications are linked to modulating B cell differentiation and function.

Personal Profile

2016-present, Assistant Professor, Department of Biology, SUSTech
2015-2016, Associate Staff Scientist, Bioprocessing Technology Institute, Singapore
2009-2015, Research Scientist, Bioprocessing Technology Institute, Singapore

2002-2009, Ph.D. (Microbiology), Fudan University, China
1997-2001, B.Sc. (Microbiology), Huazhong Agricultural University, China


1. B Cell Development

2. Humoral Immune Response


1. Microbiology (undergraduate)

2. Cellular and Molecular Immunology (postgraduate)

Publications Read More


    Publications in the past 3 years: #co-first authors, *corresponding author.

  1. Huang H, Zhang G, Ruan GX, Li Y, Chen W, Zhou J, Zhang R, Wang J, Ji SJ*, Xu S, Ou X*. Mettl14-mediated m6A modification is essential for germinal centre B cell response. Journal of Immunology 2022

  2. Ruan GX, Li Y, Chen W, Huang H, Zhang R, Chen C, Lam KP, Xu S, Ou X*. The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement. Cell Reports 2022 Feb 8;38(6):110338.

  3. Tan AH#, Tso GHW#, Zhang B#, Teo PY#, Ou X#, Ng SW, Wong AXF, Tan SJX, Sanny A, Kim SS, Lee AP, Xu S, Lam KP*. TACI Constrains TH17 Pathogenicity and Protects against Gut Inflammation. iScience 2020 Oct 22;23(11):101707.

  4. Xu S, Huo J, Huang Y, Aw M, Chen S, Mak S, Yip LY, Ho YS, Ng SW, Tan AH, Lee A, Ou X, Lam KP*. von Hippel-Lindau Protein Maintains Metabolic Balance to Regulate the Survival of Naive B Lymphocytes. iScience 2019 Jul 26;17:379-392.

  5. Ou X*, Huo J, Huang Y, Li YF, Xu S*, Lam KP*. Transcription factor YY1 is essential for iNKT cell development. Cellular & Molecular Immunology 2019 Jun;16(6):547-556.

Lab members Read More

Join us

Open Postdoctoral Position


The Ou laboratory has an opening for a highly motivated, self-driven postdoctoral fellow with background knowledge in immunology.  The successful candidate will conduct research projects focused on studying the roles of RNA splicing and modifications in B cell development and differentiaiton.

Required Qualifications: 
  • -The successful candidate must have a PhD or MD/PhD in which s/he has gained knowledge in cell and molecular biology, developmental biology, immunology, or cancer biology.
  • -Specific skills and personal attributes required include: excellent writing and presentation skills, high energy multi-tasker, supremely organized with exquisite attention to detail, ability to work independently, strong expertise with molecular and cellular biology.
  • -Collaborative team spirit, strong communication skills, positive attitude and adherence to highest ethical principles are necessary to be considered.
Required Application Materials: 
  • -Updated CV
  • -Complete contact information for three references
  • -Short cover letter describing their past research experience, career goals and a statement of future research interest (1 page)


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