Research Assistant Professor |School of Life Sciences, Academy for Advanced Interdisciplinary Studies

Dr. Fengfeng Niu, as a Research Assistant Professor (RAP), currently works

at Academy for Advanced Interdisciplinary Studies/Biology Department, SUSTech

since 2019.

He got his Ph.D (major in Structural Biology) at Institute of Biophysics, Chinese Academy of Sciences in 2015 and then moved to Department of Biology, SUSTech and started his post-doc and RAP fellow research.

He focuses on structural and bio-functional study on the key biomacromolecules in human/pathogens by employing X-ray, Cryo-EM methods combining with biochemical and cellular assay. Recently, he mainly works on the mechanism investigation on intracellular cargo transport mediated by molecular motors. His main work has been published in Science Advances, PNAS, Journal of Virology and Protein Cell.

Personal Profile


1. Structural study on the key proteins/protein complexes by employing X-ray crystallography and CryoEM methods.

2. Mechnism investigation on intracellular cargo transport mediated by molecular motors.

Publications Read More

  1. Niu, F.*, Sun, K.*, Wei, W., Yu, C., Wei, Z. F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis. Sci Adv. 2020 Nov 6;6(45):eabb1307. doi: 10.1126/sciadv.abb1307. PMID: 33158857; PMCID: PMC7673715.
  2. Niu, F.*, Shaw, N*., Wang, Y. E.*, Jiao, L.*, Ding, W., Li, X., … & Liu, Z. J. (2013). Structure of the Leanyer orthobunyavirus nucleoprotein–RNA complex reveals unique architecture for RNA encapsidation. Proceedings of the National Academy of Sciences, 110(22), 9054-9059.

  3. Jiao, L.*, Ouyang, S.*, Liang, M.*, Niu, F.*, Shaw, N., Wu, W., … & Liu, Z. J. (2013). Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential. Journal of virology, 87(12), 6829-6839.
  4. Niu, F., Ru, H., Ding, W., Ouyang, S., & Liu, Z. J. (2013). Structural biology study of human TNF receptor associated factor 4 TRAF domain. Protein & cell, 4(9), 687-694.
  5. Liang, M.*, Jin, G.*, Xie, X.*, Zhang, W., Li, K., Niu, F., Yu, C., Wei, Z. Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep. 2021 Mar 23;34(12):108901. doi: 10.1016/j.celrep.2021.108901. PMID: 33761347.
  6. Li, J. *, Rodriguez, J. P. *, Niu, F., Pu, M., Wang, J., Hung, L. W., … & Ouyang, S. (2016). Structural basis for DNA recognition by STAT6. Proceedings of the National Academy of Sciences, 113(46), 13015-13020
  7. Burakova, L. P., Natashin, P. V., Malikova, N. P., Niu, F., Pu, M., Vysotski, E. S., & Liu, Z. J. (2016). All Ca 2+-binding loops of light-sensitive ctenophore photoprotein berovin bind magnesium ions: The spatial structure of Mg2+-loaded apo-berovin. Journal of Photochemistry and Photobiology B: Biology, 154, 57-66.

  8. Jiao, L.*, Ouyang, S.*, Shaw, N., Song, G., Feng, Y., Niu, F., … & Liu, Z. J. (2014). Mechanism of the Rpn13-induced activation of Uch37. Protein & Cell, 1-15.

  9. Gu, J., Feng, Y., Feng, X., Sun, C., Lei, L., Ding, W., Niu, F., … & Han, W. (2014). Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin. PLoS pathogens, 10(5), e1004109.  
  10. Ouyang, S.*, Song, X.*, Wang, Y.*, Ru, H.*, Shaw, N., Jiang, Y., Niu, F., … & Liu, Z. J. (2012). Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity, 36(6), 1073-1086.                                                 

        (*co-first author)

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