Li Yanyan

Assistant Professor |School of Life Sciences, Department of Biology

Dr Yanyan Li is currently the assistant professor in the school of life science at Southern University of Science and Technology. Dr Li joined the laboratories at Jiangnan University, University of Maryland, Duke University and Harvard medical school as graduate and visiting scholar. The focus of Dr Li’s research is to understand the molecular basis by which Gram-negative bacteria modify the endotoxin lipopolysaccharide (LPS) and how these alterations affect or circumvent normal host innate immune system responses. The LPS related research results were published in first or corresponding author manuscripts in the journals of Nature, Cell, Cell research, Nature Communications, PNAS, Cell discovery. Three research papers were recommended by Faculty of 1000. Dr Li was funded by the natural science foundation of China and awarded with the Young investigator award from IEIIS (International endotoxin International Endotoxin and Innate Immunity Society).

Personal Profile

Research

Research Interests:

◆The focus of the laboratory is to understand the molecular basis by which Gram-negative bacteria modify the lipopolysaccharide (LPS), how these alterations affect or circumvent normal host innate immune system responses, and the structural mechanism of the LPS and lipids transportation. This study may represent a general paradigm for LPS structure to pathogenesis. Additionally, it may represent a novel pathway for new antibiotics and vaccine adjuvant development.


Publications Read More

Selected Publications ( * Corresponding author)

  1. Luo J, Yang Q, Zhang X, Zhang Y, Wan L, Zhan X, Zhou Y, He L, Li D, Jin D, Zhen Y, Huang J, Li Y*, Tao L*. TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile. Cell, 2022, 185 (6): 980-994.
  2. Xu D, Li Y, Yang F, Sun C, Pan J, Wang L, Chen Z, Fang S, Yao X, Hou W, Zhou C, Chen Y. Structure and transport mechanism of the human cholesterol transporter ABCG1. Cell Report, 2022, 38(4):110298
  3. Sharma S, Zhou R, Wan L, Feng S, Song K, Xu C, Li Y*, Liao M*. Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins. Nature communication, 2021, 12, 4697.
  4. Zhou Y, Li D, Luo J, Chen A, Li X, Pan Z, Wan L, He L, Li D, Li Y, Dong M, Tao L*. Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin. Cell Research, 2021, 31(8): 935-938
  5. Chi X, Fan Q, Zhang Y, Liang K, Wan L, Zhou Q*, Li Y*. Structural mechanism of phospholipids translocation by MlaFEDB complex. Cell Research, 2020, 30(12):1127-1135.
  6. Zhang Y, Fan Q, Chi X, Zhou Q*, Li Y*. Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter. Cell Discovery, 2020, 6(1):86.
  7. Thélot F, Orlando BJ, Li Y*, Liao M*. High-resolution views of lipopolysaccharide translocation driven by ABC transporters MsbA and LptB2FGC. Curr Opin Struct Biol. 2020, 63:26-33.
  8. Li Y+, Orlando B+, Liao M. Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature, 2019, 567(7749): 486-490
  9. Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M. Structural basis of MsbA-mediated lipopolysaccharide transport. Nature, 2017, 549(7671):233-237
  10. Li Y, Powell DA, Shaffer SA, Rasko DA, Pelletier MR, Leszyk JD, Scott AJ, Masoudi A, Goodlett DR, Wang X, Raetz CR, Ernst RK*. LPS remodeling is an evolved survival strategy for bacteria. PNAS. 2012, 109(22):8716-8721

Other Publications ( * Corresponding author)

  1. Xu Z, Liu Z, Soteyome T, Hua J, Zhang L*, Yuan L, Ye Y, Cai Z, Yang L, Chen L, Harro JM, Kjellerup BV, Liu J, Li Y*. Impact of pmrA on Cronobacter sakazakii planktonic and biofilm cells: A comprehensive transcriptomic study. Food Microbiology, 2021, 98: 103785.
  2. Hua J, Jia X, Zhang L*, Li Y*. The Characterization of Two-Component System PmrA/PmrB in Cronobacter sakazakii. Front Microbiol. 2020, 11:903.
  3. Jia X, Hua J, Liu L, Xu Z, Li Y*. Phenotypic characterization of pathogenic Cronobacter spp. strains. Microbial Pathogenesis. 2018, 121:232-237
  4. Yun J, Wang X, Zhang L*, Li Y*. Effects of lipid acyltransferases on the pathogenesis of F. novicida. Microbial Pathogenesis. 2017, 109:313-318
  5. Bao X, Jia X, Chen L, Peters B, Lin C, Chen D, Li L, Li B, Li Y*, Xu Z*, Shirtliff M. Effect of polymyxin resistance (pmr) on biofilm formation of Cronobacter sakazakii. Microbial Pathogenesis. 2017, 106:16-19
  6. Li Y*, Yoon SH, Wang X, Ernst RK, Goodlett DR*. Structural Derivation of lipid A from Cronobacter sakazakii using Tandem Mass Spectrometry. Rapid Commun Mass Spectrom. 2016, 30(20): 2265-70
  7. Liu L, Li Y*, Wang X*, Guo W. A phosphoethanolamine transferase specific for the 4′-phosphateresidue of Cronobacter sakazakii lipid A. J Appl Microbiol. 2016, 121(5):1444-1456
  8. Li Y*, Yun J, Liu L, Li Y, Wang X. Identification of Two Genes Encoding for the Late Acyltransferases of Lipid A in Klebsiella pneumoniae. Curr Microbiol. 2016, 73(5), 732-738
  9. Chen C, Li Y, Hu J, Dong X, Wang X. Metabolic engineering of Corynebacterium glutamicum ATCC13869 for L-valine production. Metab Eng. 2015, 29, 66-75
  10. Li Y, Wang Z, Chen J, Ernst RK, Wang X*. Influence of lipid A acylation pattern on membrane permeability and innate immune stimulation. Marine Drugs. 2013,11(9), 3197-3208.

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Contact Address

1088 Xueyuan Avenue, Shenzhen 518055, P.R. China

Office Phone

0755-88011101

Email

liyy6@sustech.edu.cn

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