Research Assistant Professor |School of Life Sciences, Department of Biology

Bioinformatics research was my first step in my research experience when I was a master student at China Agricultural University, followed by the cryo-EM electron diffraction research that was my PhD project at Leiden University in the Netherlands. After that, I went back to Tsinghua University as a postdoc scientist and did the helical reconstruction method using cryo-EM. I was the first researcher in China who solved the structure of amyloid fiber in Parkinson’s disease at the near-atomic resolution. Currently I am a Research Assistant Professor at Southern University of Science and Technology.

Personal Profile

Introduction

Bioinformatics research was my first step in my research experience when I was a master student at China Agricultural University, followed by the cryo-EM electron diffraction research that was my PhD project at Leiden University in the Netherlands. After that, I went back to Tsinghua University as a postdoc scientist and did the helical reconstruction method using cryo-EM. I was the first researcher in China who solved the structure of amyloid fiber in Parkinson’s disease at the near-atomic resolution. Currently I am a Research Assistant Professor at Southern University of Science and Technology.

Research Interests:

Cryo-EM technology was mainly my research interest. Including but not limit to the electron diffraction and single particle analysis, I also have a great focus on the cryo-ET. In short, I want to investigate the mechanism of life through different methods, seeing is believing.   

Professional Experience:

◆2021-Now, Research Assistant Professor, Southern University of Science and Technology.

◆ 2017-2021, Postdoc, Tsinghua University

◆ 2015-2017, Postdoc and guest, Leiden University 

Educational Background:

◆ 2011-2017, PhD, Leiden University

◆ 2008-2011, Master, China Agricultural University

◆ 2004-2008, Bachelor, Jiangxi Agricultural University

Honors & Awards:

2018 Travel Award of 2018 Kuo symposium on 3D-EM of macromolecules and cells

2018 National Natural Science Funds of China (Grant No.31800709)

2017 General Financial Grant from the China Postdoctoral Science Foundation. (Grant No.2017M620752)

2017 Postdoc research support of Tsinghua University

2017 Advanced Innovation Fellow of Beijing Advanced Innovation Center for structural biology, Tsinghua University

2011 Scholarship of CSC for PhD research

2011 The top 10 thesis at China Agricultural University

2009 Scholarship of scientific achievement at China Agricultural University

Selected Publication:

1. Zhao K.*, Li Y.W.*, Liu Z., Long H. Zhao C., Luo F., Sun Y., Tao Y., Su X., Li D., Li X., Liu C.,(2020) Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a novel fibril structure, Nature Communications, pp. 2643 (* co-first author.)
2. Li Y.W.*, Zhao C.*, Luo F.*, Liu Z., Gui X., Luo Z., Zhang X., Li D., Liu C., Li X. (2018) Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy, Cell Research, pp. 1-7 (* co-first author)
3. Wang R., Fang S., Xiao Y., Gao E., Jiang N., Li, Y.W., Mou L., Shen Y., Zhao W., Li S.,FonSeca A., Galvao D., Chen M., He W., Yu K., Lu H., Wang X., Qian D., Aliev A., Li N.,Haines C., Liu Z., Mu J., Wang Z., Yin S., Lima M., An B., Zhou X., Liu Z., Baughman R.(2019)Torsional refrigeration by twisted, coiled, and supercoiled fibers, Science, pp. 216-221.
4. van Genderen E.*, Li Y.W.*, Nederlof I., Abrahams,J.P. (2016) Lattice filter for processing image data of three-dimensional protein nanocrystals, Acta Crystallographica Section D: Biological Crystallography, vol 72, pp. 34-39. (* co-first author)

5. Nederlof, I, Li Y.W., van Heel, M., Abrahams, J.P., (2013) Imaging protein three-dimensional nanocrystals with cryo-EM, Acta Crystallographica Section D-Biological Crystallography,vol. 69, pp. 852-859.

6. Nederlof, I, van Genderen, E., Li Y.W., Abrahams, J.P., (2013) A Medipix quantum area detector allows rotation electron diffraction data collection from submicrometre three-dimensional protein crystals, Acta Crystallographica Section D-Biological Crystallography, 69, pp. 1223-1230.

7. Li Y.W., Li B., He J., Qian P.,(2011) Structure-activity relationship study of antioxidative peptides by QSAR modeling: the amino acid next to C-terminal affects the activity. Journal of peptide science,17(6),pp.454-462.

Research

Cryo-EM technology was mainly my research interest. Including but not limit to the electron diffraction and single particle analysis, I also have a great focus on the cryo-ET. In short, I want to investigate the mechanism of life through different methods, seeing is believing.


Publications Read More

  1. Zhao K.*, Li Y.W.*, Liu Z., Long H. Zhao C., Luo F., Sun Y., Tao Y., Su X., Li D., Li X., LiuC.,(2020) Parkinson’s disease associated mutation E46K of α-synuclein triggers the formationof a novel fibril structure, Nature Communications, pp. 2643 (* co-first author.)

    2. Li Y.W.*, Zhao C.*, Luo F.*, Liu Z., Gui X., Luo Z., Zhang X., Li D., Liu C., Li X. (2018) Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy, Cell Research, pp. 1-7 (* co-first author)

    3. Wang R., Fang S., Xiao Y., Gao E., Jiang N., Li, Y.W., Mou L., Shen Y., Zhao W., Li S.,FonSeca A., Galvao D., Chen M., He W., Yu K., Lu H., Wang X., Qian D., Aliev A., Li N.,Haines C., Liu Z., Mu J., Wang Z., Yin S., Lima M., An B., Zhou X., Liu Z., Baughman R.(2019)Torsional refrigeration by twisted, coiled, and supercoiled fibers, Science, pp. 216-221.

    4. van Genderen E.*, Li Y.W.*, Nederlof I., Abrahams,J.P. (2016) Lattice filter for processing image data of three-dimensional protein nanocrystals, Acta Crystallographica Section D: Biological Crystallography, vol 72, pp. 34-39. (* co-first author)

  2. Nederlof, I, Li Y.W., van Heel, M., Abrahams, J.P., (2013) Imaging protein three-dimensional nanocrystals with cryo-EM, Acta Crystallographica Section D-Biological Crystallography,vol. 69, pp. 852-859.
  3. Nederlof, I, van Genderen, E., Li Y.W., Abrahams, J.P., (2013) A Medipix quantum area detectorallows rotation electron diffraction data collection from submicrometre three-dimensional proteincrystals, Acta Crystallographica Section D-Biological Crystallography, 69, pp. 1223-1230.
  4. Li Y.W., Li B., He J., Qian P.,(2011) Structure-activity relationship study of antioxidative peptides by QSAR modeling: the amino acid next to C-terminal affects the activity. Journal of peptide science,17(6),pp.454-462.

Lab members Read More

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Contact Address

Department of Biology, College of Life Science, Southern University of Science and Technology Xueyuan avenue 1088, Nanshan district, Shenzhen, Guangdong, China

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Email

liyw@sustech.edu.cn

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