李凯

研究员 生物医学工程系

李凯博士,副教授/研究员,国家特聘专家(青年)。2003年毕业于北京化工大学获得学士学位,2006年毕业于韩国忠南国立大学获得硕士学位,2011年于新加坡国立大学化学与生物分子工程系获得博士学位,并获得了国家优秀自费留学生奖学金。随后加入新加坡科技研究局材料与工程研究院任研究科学家,开发的有机荧光示踪探针曾被Nature杂志专题报道。2013年获得新加坡科技研究局优秀青年研究员奖并开展独立研究,2015-2017年作为访问学者加入斯坦福大学分子影像中心进行合作研究,2018年加入南方科技大学生物医学工程系任副教授。迄今在Chemical Society Reviews、Angewandte Chemie、Advanced Materials、ACS Nano等期刊发表学术论文100余篇,总被引超过7,500次 (Web of Science),当前H-index为46。主持国家自然科学基金委员会面上项目、联合基金重点支持项目、深圳市科创委技术攻关重点项目等科研项目,并作为骨干成员参与科技部国家重点研发计划“合成生物学”重点专项。

个人简介

个人简介:

李凯博士,副教授/研究员,国家特聘专家(青年)。2003年毕业于北京化工大学获得学士学位,2006年毕业于韩国忠南国立大学获得硕士学位,2011年于新加坡国立大学化学与生物分子工程系获得博士学位,并获得了国家优秀自费留学生奖学金。随后加入新加坡科技研究局材料与工程研究院任研究科学家,开发的有机荧光示踪探针曾被Nature杂志专题报道。2013年获得新加坡科技研究局优秀青年研究员奖并开展独立研究,2015-2017年作为访问学者加入斯坦福大学分子影像中心进行合作研究,2018年加入南方科技大学生物医学工程系任副教授。迄今在Chemical Society Reviews、Angewandte Chemie、Advanced Materials、ACS Nano等期刊发表学术论文100余篇,总被引超过7,500次 (Web of Science),当前H-index为46。主持国家自然科学基金委员会面上项目、联合基金重点支持项目、深圳市科创委技术攻关重点项目等科研项目,并作为骨干成员参与科技部国家重点研发计划“合成生物学”重点专项。

教育背景:

1999年-2003年 北京化工大学材料科学与工程学院 本科

2004年-2006年 忠南国立大学高分子工学系 硕士

2008年-2011年 新加坡国立大学化学与生物分子系 博士

工作经历:

2018年-至今 南方科技大学生物医学工程系 研究员

2015年-2017年 斯坦福大学医学院分子影像中心 访问学者

2011年-2018年 新加坡科研局材料工程研究院 研究科学家, PI

荣誉及奖励:

2019年  深圳市海外高层次人才B类、广东省优粤人才以及南山区领航人才

2016年 世界分子影像大会Travel Award

2015年 新加坡科技研究局International Fellowship

2013年 新加坡科技研究局年轻研究员职业发展奖

2011年 教育部优秀自费留学生奖学金

2008年 新加坡国立大学校长奖学金

2004年 韩国科技财团优秀外国留学生奖学金

2003年 北京地区高校优秀毕业生

代表论文:

  1. Guang Yang,[a,+] Jen-Shyang Ni,[a,+] Yaxi Li,[a] Menglei Zha,[a] Yao Tu,[a] and Kai Li*[a]. Acceptor Engineering for Optimized ROS Generation Facilitates Reprogramming Macrophages to M1 Phenotype in Photodynamic Immunotherapy. Angew. Chem. Int. Ed. 2020, doi: 10.1002/anie.202013228.
  2. Zonghai Sheng, Yaxi Li, Dehong Hu, Tianliang Min, Duyang Gao, Jen-Shyang Ni, Pengfei Zhang, Yuenan Wang, Xin Liu, Kai Li,* Hairong Zheng,* Ben Zhong Tang.* Centimeter-deep NIR-II fluorescence imaging with nontoxic AIE probes in non-human primates. Research 2020, Accepted (Article ID 4074593).
  3. Menglei Zha,† Xiangwei Lin,† Jen-Shyang Ni,†,* Yaxi Li, Yachao Zhang, Xun Zhang, Lidai Wang,* Kai Li.* An ester-substituted semiconducting polymer with efficient nonradiative decay enhances NIR-II photoacoustic performance for monitoring of tumor growth. Angew. Chem. Int. Ed. 2020, doi: 10.1002/anie.202010228 (†contributed equally).
  4. Yaxi Li,† Dehong Hu,† Zonghai Sheng, Tianliang Min, Menglei Zha, Jen-Shyang Ni, Hairong Zheng,* Kai Li.* Self-assembled AIEgen nanoparticles for multiscale NIR-II vascular imaging. Biomaterials 2020, doi: 10.1016/j.biomaterials.2020.120365 (†contributed equally).
  5. Xuanyu Li,† Menglei Zha,† Yaxi Li, Jen-Shyang Ni, Tianliang Min, Tianyi Kang, Guang Yang, Hao Tang, Kai Li,* Xingyu Jiang.* Sub-10 nm aggregation-induced emission quantum dots assembled by microfluidics for enhanced tumor-targeting and reduced retention in the liver. Angew. Chem. Int. Ed. 2020, doi: 10.1002/anie.202008564 (†contributed equally).
  6. Jen-Shyang Ni,† Xun Zhang,† Guang Yang, Tianyi Kang, Xiangwei Lin, Menglei Zha, Yaxi Li, Lidai Wang, Kai Li*. Photoinduced nonadiabatic decay-guided molecularmotor triggers effective photothermal conversion for hyperthermia cancer therapy. Angew. Chem. Int. Ed. 2020, doi: 10.1002/ange.202002516 (†contributed equally).
  7. Jen-Shyang Ni, Tianliang Min, Yaxi Li, Menglei Zha, Pengfei Zhang, Chun Loong Ho, Kai Li.* Planar AIEgens with Enhanced Solid-State Luminescence and ROS-Generation for Multidrug-Resistant Bacteria Treatment. Angew. Chem. Int. Ed. 2020, doi:10.1002/anie.202001103 (contributed equally).
  8. Jen-Shyang Ni, Yaxi Li, Wentong Yue, Bin Liu,*Kai Li.* Nanoparticle-based cell trackers for biomedical applications. Theranostics. 2020, 10, 1923-1947. (contributed equally).
  9. Huaxiao Yang,* Xulei Qin, Huiyuan Wang, Xin Zhao, Yonggang Liu, Hung-Ta Wo, Chun Liu, Masataka Nishiga, Haodong Chen, Jing Ge, Nazish Sayed, Oscar J. Abilez, Dan Ding, Sarah C. Heilshorn, Kai Li.* An in vivo miRNA delivery system for restoring infarcted myocardium. ACS Nano. 2019, 13, 9880-9894.
  10. Xulei Qin, Haodong Chen, Huaxiao Yang, Haodi Wu, Xin Zhao, Huiyuan Wang, Tony Chour, Evgenios Neofytou, Dan Ding, Heike Daldrup-Link, Sarah C. Heilshorn, Kai Li,* Joseph C. Wu,* Photoacoustic imaging of embryonic stem cell-derived cardiomyocytes in living hearts with ultrasensitive semiconducting polymer nanoparticles. Adv. Funct. Mater. 2018, 28, 1704939.
  11. Heqi Gao, Xiaoyan Zhang, Chao Chen, Kai Li,* Dan Ding.* Unity makes strength: how aggregation-induced emission luminogens advance the biomedical field. Adv. Biosys. 2018, 2, 1800074 (Invited Review).
  12. Kai Li,* Hossein Nejadnik, Heike E. Daldrup-Link,* Next generation superparamagnetic iron oxide nanoparticles for cancer theranostics. Drug Discov. Today 2017, 22, 1421-1429 (Invited Review).
  13. Guorui Jin, Guangxue Feng, Wei Qin, Ben Zhong Tang, Bin Liu,* Kai Li,* Multifunctional organic nanoparticles with aggregation-induced emission (AIE) characteristics for targeted photodynamic therapy and RNA interference therapy. Chem. Commun. 2016, 52, 2752-2755 (*corresponding author).
  14. Guorui Jin, Duo Mao, Pingqiang Cai, Rongrong Liu, Nikodem Tomczak, Jie Liu, Xiaodong Chen, Deling Kong, Dan Ding,* Bin Liu,* Kai Li,* Conjugated polymer nanodots as ultrastable long-term trackers to understand mesenchymal stem cell therapy in skin regeneration. Adv. Funct. Mater. 2015, 25, 4263-4273 (Frontispiece Story).
  15. Jie Liu, Kai Li,* Bin Liu,* Far-red/near-infrared conjugated polymer nanoparticles for long-term in-situ monitoring of liver tumor growth. Adv. Sci. 2015, 2, 1500008.
  16. Kai Li, Bin Liu, Polymer-encapsulated organic nanoparticles for fluorescence and photoacoustic imaging. Chem. Soc. Rev. 2014, 43, 6570-6597.
  17. Dan Ding,† Duo Mao,† Kai Li,† Xiaomin Wang, Wei Qin, Rongrong Liu, David Shunzhong Chiam, Nikodem Tomczak, Zhimou Yang, Ben Zhong Tang, Deling Kong, Bin Liu (†contributed equally), Precise and long-term tracking of adipose-derived stem cells and their regenerative capacity via superb bright and stable organic nanodots. ACS Nano 2014, 8, 12620-12631.
  18. Wei Qin,† Kai Li,† Guangxue Feng, Min Li, Zhiyong Yang, Bin Liu, Ben Zhong Tang, Bright and photostable organic fluorescent dots with aggregation-induced emission characteristics for noninvasive long-term cell imaging. Adv. Funct. Mater. 2014, 24, 635-643 (†contributed equally).
  19. Guangxue Feng,† Kai Li,† Jie Liu, Dan Ding, Bin Liu, Bright single-chain conjugated polymer dots embedded nanoparticles for long-term cell tracing and imaging. Small 2014, 10, 1212-1219 (†contributed equally).
  20. Kai Li, Wei Qin, Dan Ding, Nikodem Tomczak, Junlong Geng, Rongrong Liu, Jianzhao Liu, Xinhai Zhang, Hongyu Liu, Bin Liu, Ben Zhong Tang, Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing. Sci. Rep. 2013, 3, 1150 (Highlighted by Nature News).
  21. Kai Li, Zhenshu Zhu, Zujin Zhao, Nikodem Tomczak, Pingqiang Cai, Rongrong Liu, Jie Liu, Wei Qin, Yong Hu, Xiaodong Chen, Ben Zhong Tang, Bin Liu, Organic dots with aggregation-induced emission (AIE dots) characteristics for dual-color cell tracing. Chem. Mater. 2013, 25, 4181-4187.
  22. Kai Li, Dan Ding, Da Huo, Kan-Yi Pu, Ngo Nguyen Phuong Thao, Yong Hu, Zhi Li, Bin Liu, Conjugated polymer based nanoparticles as dual-modal probes for targeted in vivo fluorescence and magnetic resonance imaging. Adv. Funct. Mater. 2012, 22, 3107-3115.
  23. Kai Li, Yutao Liu, Kan-Yi Pu, Si-Shen Feng, Ruoyu Zhan, Bin Liu, Polyhedral oligomeric silsesquioxanes-containing conjugated polymer loaded PLGA nanoparticles with Trastuzumab (Herceptin) functionalization for HER2-positive cancer cell detection. Adv. Funct. Mater. 2011, 21, 287-294 (Inside Front Cover Story).
  24. Kai Li, Jie Pan, Si-Shen Feng, Arthur Wenqing Wu, Kan-Yi Pu, Yutao Liu, Bin Liu, Generic strategy of preparing fluorescent conjugated polymer-loaded poly(dl-lactide-co-glycolide) nanoparticles for targeted cell imaging. Adv. Funct. Mater. 2009, 19, 3535-3542 (Frontispiece Story).

 

研究领域

分子探针与光学成像、光动力抗菌纤维、光免疫治疗


教学

主讲课程:纳米生物医学(研究生)


学术成果 查看更多

(Google Scholar Metrics: H-Index = 47Citations > 8000,

https://scholar.google.com/citations?user=GGfBsSQAAAAJ&hl=zh-CN&oi=ao)

 
2022

1.     Jun Wang,† Qinzhen Li,† Hui Zhao, Wentong Yue, Kaiwen Zhang, Xingyu Jiang,* Kai Li.* Facile and controllable synthesis of the renal-clearable “luminous pearls” for in vivo afterglow/magnetic resonance imaging, ACS Nano 2022, 16, 462-472 (†contributed equally).

2.     Jun, Wang,† Menglei Zha,† Hui Zhao,† Wentong Yue, Decheng Wu, Kai Li.* Detection of kidney dysfunction through in vivo magnetic resonance imaging with renal-clearable gadolinium nanoprobes. Anal. Chem. 2022, doi: 10.1021/acs.analchem.1c05140 (†contributed equally).

3.     Yaxi Li,† Menglei Zha,† Tianyi Kang, Chong Li, Xue Wu, Shuxian Wang, Song-Bo Lu, Yi-Shan Lee, Yun-Rong Wu, Jen-Shyang Ni,* Kai Li.* Promoted NIR-II fluorescence by heteroatom-inserted rigid-planar cores for monitoring cell therapy of acute lung injury. Small 2022, 18, 2105362 (†contributed equally).

 

2021

4.     Guang Yang,† Song-Bo Lu,† Chong Li, Feng Chen, Jen-Shyang Ni, Menglei Zha, Yaxi Li, Ji Gao, Tianyi Kang, Chao Liu, Kai Li.* Type I macrophage activator photosensitizer against hypoxic tumor. Chem. Sci. 2021, 12, 14773-14780. (†contributed equally).

5.     Yaxi Li,† Hongli Zhou,† Renzhe Bi, Xiuting Li, Menglei Zha, Yanqing Yang, Jen-Shyang Ni, Weng Heng Liew, Malini Olivo, Kui Yao, Jie Liu,* Hao Chen,* Kai Li.* Acceptor engineering of small molecule fluorophores for NIR-II fluorescent and photoacoustic imaging. J. Mater. Chem. B 2021, 9, 9951-9960 (†contributed equally).

6.     Tianyi Kang,† Jen-Shyang Ni,† Tingting Li, Jun Wang, Zeshun Li, Yaxi Li, Menglei Zha, Chen Zhang, Xue Wu, Heng Guo, Lei Xi, Kai Li.* Efficient and precise delivery of microRNA by photoacoustic force generated from semiconducting polymer-based nanocarriers. Biomaterials 2021, 275, 120907 (†contributed equally).

7.     Fei Ren,† Zeshun Li,† Kai Li,* Xiaoyan Zheng,* Jianbing Shi,* Chen Zhang, Heng Guo, Bin Tong, Lei Xi, Zhengxu Cai, Yuping Dong.* Donor strategy for promoting nonradiative decay to achieve an efficient photothermal therapy for treating cancer. Sci. China Chem. 2021, 64, 1530-1539 (†contributed equally).

8.     Menglei Zha, Guang Yang,* Yaxi Li, Chen Zhang, Bo Li,* Kai Li.* Recent advances in AIEgen-based photodynamic therapy and immunotherapy. Adv. Healthcare Mater. 2021, 10, 2101066 (Invited Review).

9.     Weizhi Qi,† Tingting Li,† Chen Zhang,† Fei Liu, Jun Wang, Dandan Chen, Xiaofeng Fang, Changfeng Wu,* Kai Li,* Lei Xi.* Light-controlled precise delivery of NIR-responsive semiconducting polymer nanoparticles with promoted vascular permeability. Adv. Healthcare Mater. 2021, 10, 2100569 (†contributed equally).

10.  Yaxi Li,† Menglei Zha,† Guang Yang, Shuxian Wang, Jen-Shyang Ni,* Kai Li.* NIR-II fluorescent brightness promoted by “ring fusion” for the detection of intestinal inflammation. Chem. Eur. J. 2021, 27, 13085-13091(†contributed equally).

11.  Zeshun Li,† Tingting Li,† Chen Zhang,† Jen-Shyang Ni, Yaoyao Ji, Aihui Sun, Dinglu Peng, Weijun Wu, Lei Xi,* Kai Li.* A multispectral photoacoustic tracking strategy for wide-field and real-time monitoring of macrophages in inflammation. Anal. Chem. 2021, 93, 8467-8475 (†contributed equally).

12.  Hao Chen,† Huaxiao Yang,† Chen Zhang, Si Chen, Xin Zhao, Mark Zhu, Zhiming Wang, Yuebing Wang, Hung-Ta Wo, Kai Li,* Zhen Cheng.* Differential responses of transplanted stem cells to diseased environment unveiled by a molecular NIR-II cell tracker. Research 2021, 2021, 9798580 (†contributed equally).

13.  Yaxi Li,† Zeshun Li,† Dehong Hu,† Shuxian Wang, Menglei Zha, Song-Bo Lu, Zonghai Sheng, Kai Li.* Targeted NIR-II emissive nanoprobes for tumor detection in mice and rabbits. Chem. Commun. 2021, 57, 6420-6423 (†contributed equally).

14.  Jun Wang,† Tingting Li,† Jen-Shyang Ni,† Heng Guo, Tianyi Kang, Zeshun Li, Menglei Zha, Songbo Lu, Chen Zhang, Weizhi Qi, Lei Xi,* Kai Li.* Photoacoustic force-guided precise and fast delivery of nanomedicine with boosted therapeutic efficacy. Adv. Sci. 2021, 8, 2100228 (†contributed equally).

15.  Guang Yang,† Jen-Shyang Ni,† Yaxi Li, Menglei Zha, Yao Tu, Kai Li.* Acceptor engineering for optimized ROS generation facilitates reprogramming macrophages to M1 phenotype in Photodynamic Immunotherapy. Angew. Chem. Int. Ed. 2021, 60, 5386-5393 (†contributed equally). (Hot Paper)

16.  Wei Zhu,† Miaomiao Kang,† Qian Wu, Zhijun Zhang, Yi Wu, Chunbin Li, Kai Li,* Lei Wang, Domng Wang,* Ben Zhong Tang.* Zwitterionic AIEgens: rational molecular design for NIR-II fluorescence imaging-guided synergistic phototherapy. Adv. Funct. Mater. 2021, 31, 202007026 (†contributed equally).

17.  Yan-Long Ma,† Chen Sun,† Zeshun Li, Ziyi Wang, Jianwen Wei, Qian Cheng, Li-Shuo Zheng, Xiao-Yong Chang, Kai Li, Ruibing Wang,* Wei Jiang,* Biomimetic recognition-based biorthogonal host-guest pairs for cell targeting and tissue imaging in living animals. CCS Chem. 2021, 3, 2143-2155 (†contributed equally).

18.  Aihui Sun, Tingting Li, Tian Jin, Yaxi Li, Kai Li, Chaolong Song, Lei Xi,*Acoustic standing wave aided multiparametric photoacoustic imaging flow cytometry. Anal. Chem. 2021, 93, 14820-14827.

19.  Tian Jin, Chen Zhang, Fei Liu, Xingxing Chen, Guangru Liang, Fei Ren, Suzi Liang, Chaolong Song, Jianbing Shi, Weibao Qiu, Xingyu Jiang, Kai Li, Lei Xi,* On-chip multicolor photoacoustic imaging flow cytometry. Anal. Chem. 2021, 93, 8134-8142.

20.  Xun Zhang,† Yanqing Yang,† Tianyi Kang, Jun Wang, Guang Yang, Yuming Yang, Xiangwei Lin, Lidai Wang, Kai Li, Jie Liu,* Jen-Shyang Ni,* NIR‐II absorbing semiconducting polymer‐triggered gene‐directed enzyme prodrug therapy for cancer treatment. Small 2021, 17, e2100501 (†contributed equally).

21.  Haifei Wen, Zhijun Zhang,* Miaomiao Kang, Haoxuan Li, Wenhan Xu, Heng Guo, Youmei Li, Yonghong Tan, Ziyao Wen, Qian Wu, Jiachang Huang, Lei Xi, Kai Li, Lei Wang, Dong Wang,* Ben Zhong Tang,* One-for-all phototheranostics: single component AIE dots as multi-modality theranostic agent for fluorescence-photoacoustic imaging-guided synergistic cancer therapy. Biomaterials 2021, 274, 120892.

 

2020

22.  Zonghai Sheng, Yaxi Li, Dehong Hu, Tianliang Min, Duyang Gao, Jen-Shyang Ni, Pengfei Zhang, Yuenan Wang, Xin Liu, Kai Li,* Hairong Zheng,* Ben Zhong Tang.* Centimeter-deep NIR-II fluorescence imaging with nontoxic AIE probes in non-human primates. Research 2020, 2020, 4074593.

23.  Menglei Zha,† Xiangwei Lin,† Jen-Shyang Ni,†,* Yaxi Li, Yachao Zhang, Xun Zhang, Lidai Wang,* Kai Li.* An ester-substituted semiconducting polymer with efficient nonradiative decay enhances NIR-II photoacoustic performance for monitoring of tumor growth. Angew. Chem. Int. Ed. 2020, 59, 23268-23276 (†contributed equally).

24.  Yaxi Li,† Dehong Hu,† Zonghai Sheng, Tianliang Min, Menglei Zha, Jen-Shyang Ni, Hairong Zheng,* Kai Li.* Self-assembled AIEgen nanoparticles for multiscale NIR-II vascular imaging. Biomaterials 2021, 264, 120365 (†contributed equally).

25.  Xuanyu Li,† Menglei Zha,† Yaxi Li, Jen-Shyang Ni, Tianliang Min, Tianyi Kang, Guang Yang, Hao Tang, Kai Li,* Xingyu Jiang.* Sub-10 nm aggregation-induced emission quantum dots assembled by microfluidics for enhanced tumor-targeting and reduced retention in the liver. Angew. Chem. Int. Ed. 2020, 59, 21899-21903 (†contributed equally). (Hot Paper)

26.  Jen-Shyang Ni,† Xun Zhang,† Guang Yang, Tianyi Kang, Xiangwei Lin, Menglei Zha, Yaxi Li, Lidai Wang, Kai Li.* A photoinduced nonadiabatic decay-guided molecular motor triggers effective photothermal conversion for hyperthermia cancer therapy. Angew. Chem. Int. Ed. 2020, 59, 11298-11302 (†contributed equally).

27.  Jen-Shyang Ni,† Tianliang Min,† Yaxi Li, Menglei Zha, Pengfei Zhang, Chun Loong Ho, Kai Li.* Planar AIEgens with enhanced solid-state luminescence and ROS-generation for multidrug-resistant bacteria treatment. Angew. Chem. Int. Ed. 2020, 59, 10179-10185 (†contributed equally).

28.  Jen-Shyang Ni,† Yaxi Li,† Wentong Yue, Bin Liu,* Kai Li.* Nanoparticle-based cell trackers for biomedical applications. Theranostics 2020, 10, 1923-1947 (†contributed equally).

29.  Zhijun Zhang, Wenhua Xu, Miaomiao Kang, Haifei Wen, Heng Guo, Pengfei Zhang, Lei Xi, Kai Li, Lei Wang, Dong Wang,* Ben Zhong Tang.* An all‐round athlete on the track of phototheranostics: subtly regulating the balance between radiative and nonradiative decays for multimodal imaging‐guided synergistic therapy. Adv. Mater. 2020, 32, 2003210.

30.  Jiachang Huang, Benzhao He, Zhijun Zhang, Youmei Li, Miaomiao Kang, Yuanwei Wang, Kai Li, Dong Wang,* Ben Zhong Tang,* Aggregation‐induced emission luminogens married to 2D black phosphorus nanosheets for highly efficient multimodal theranostics. Adv. Mater. 2020, 32, 2003382.

31.  Wenhan Xu,† Zhijun Zhang,† Miaomiao Kang, Heng Guo, Youmei Li, Haifei Wen, Michelle M. S. Lee, Zhaoyu Wang, Ryan T. K. Kwok, Jacky W. Y. Lam, Kai Li, Lei Xi*, Sijie Chen, Dong Wang*, Ben Zhong Tang.* Making the best use of excited-state energy: Multimodality theranostic systems based on second near-infrared (NIR-II) aggregation-induced emission luminogens (AIEgens). ACS Materials Lett. 2020, 2, 1033-1040 (†contributed equally).

32.  Qiyao Li,† Ying Li,† Tianliang Min,† Junyi Gong, Lili Du, David Lee Phillips, Junkai Liu, Jacky W. Y. Lam, Herman H. Y. Sung, Ian D. Williams, Ryan T. K. Kwok, Chun Loong Ho, Kai Li, Jianguo Wang,* Ben Zhong Tang.* Time‐dependent photodynamic therapy for multiple targets: a highly efficient AIE‐active photosensitizer for selective bacterial elimination and cancer cell ablation. Angew. Chem. Int. Ed. 2020, 59, 9470-9477 (†contributed equally).

 

2019

33.  Huaxiao Yang,* Xulei Qin, Huiyuan Wang, Xin Zhao, Yonggang Liu, Hung-Ta Wo, Chun Liu, Masataka Nishiga, Haodong Chen, Jing Ge, Nazish Sayed, Oscar J. Abilez, Dan Ding, Sarah C. Heilshorn, Kai Li.* An in vivo miRNA delivery system for restoring infarcted myocardium. ACS Nano 2019, 13, 9880-9894.

34.  Ashok J. Theruvath,† Hossein Nejadnik,† Olga Lenkov, Ketan Yerneni, Kai Li, Lara Kuntz, Cody Wolterman, Jutta Tuebel, Rainer Burgkart, Tie Liang, Stephen Felt, Heike E. Daldrup-Link.* Tracking stem cell implants in cartilage defects of minipigs by using ferumoxytol-enhanced MRI. Radiology 2019, 292, 182176.

35.  Guorui Jin, Rongyan He, Qian Liu, Min Lin, Yuqing Dong, Kai Li, Ben Zhong Tang, Bin Liu, Feng Xu. Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles. Theranostics 2019, 9, 246-264.

36.  Xin-Chi Jiang, Jia-Jia Xiang, Hong-Hui Wu, Tian-Yuan Zhang, Dan-Ping Zhang, Qian-Hao Xu, Xiao-Li Huang, Xiang-Lei Kong, Ji-Hong Sun, Yu-Lan Hu, Kai Li, Yasuhiko Tabata, You-Qing Shen, Jian-Qing Gao. Neural stem cells transfected with reactive oxygen species-responsive polyplexes for effective treatment of ischemic stroke. Adv. Mater. 2019, 31, 1807591.

 

2018

37.  Xulei Qin,† Haodong Chen,† Huaxiao Yang,† Haodi Wu, Xin Zhao, Huiyuan Wang, Tony Chour, Evgenios Neofytou, Dan Ding, Heike Daldrup-Link, Sarah C. Heilshorn, Kai Li,* Joseph C. Wu.* Photoacoustic imaging of embryonic stem cell-derived cardiomyocytes in living hearts with ultrasensitive semiconducting polymer nanoparticles. Adv. Funct. Mater. 2018, 28, 1704939 (†contributed equally).

38.  Heqi Gao, Xiaoyan Zhang, Chao Chen, Kai Li,* Dan Ding.* Unity makes strength: how aggregation-induced emission luminogens advance the biomedical field. Adv. Biosys. 2018, 2, 1800074 (Invited Review).

39.  Kai Li, † Carmel T. Chan, † Hossein Nejadnik, † Olga D. Lenkov, Cody Wolterman, Ramasamy Paulmurugan, Huaxiao Yang, Sanjiv Sam Gambhir, Heike E. Daldrup-Link. Ferumoxytol-based dual-modality imaging probe for detection of stem cell transplant rejection. Nanotheranostics 2018, 2, 306-319 (†contributed equally).

40.  Xiang Ni, Shaorui Jia, Xingchen Duan, Dan Ding,* Kai Li.* Fluorescent nanoparticles for noninvasive stem cell tracking in regenerative medicine. J. Biomed. Nanotechnol. 2018, 14, 240-256 (Invited Review).

 

2017

41.  Kai Li,* Hossein Nejadnik, Heike E. Daldrup-Link.* Next generation superparamagnetic iron oxide nanoparticles for cancer theranostics. Drug Discov. Today 2017, 22, 1421-1429 (Invited Review).

42.  Guorui Jin, Jun Li, Kai Li.* Photosensitive semiconducting polymer-incorporated nanofibers for promoting the regeneration of skin wound. Mater. Sci. Eng. C 2017, 70, 1176-1181.

43.  Suchismita Mohanty, Zixin Chen, Kai Li, Goreti Ribeiro Morais, Jessica Klockow, Ketan Yerneni, Laura Pisani, Frederick T. Chin, Siddhartha Mitra, Samuel Cheshier, Edwin Chang, Sanjiv Sam Gambhir, Jianghong Rao, Paul M. Loadman, Robert A. Falconer, Heike E. Daldrup-Link. A novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival. Mol. Cancer Ther. 2017, 16, 1909-1921.

44.  Hossein Nejadnik,† Seyedmeghdad Taghavigarmestani,† Steven Madsen, Kai Li, Saeid Zanganeh, Phillip Yang, Morteza Mahmoudi, Heike E. Daldrup-Link. The protein corona around nanoparticles facilitates stem cell labeling for clinical MRI. Radiology 2017, DOI: 10.1148/radiol.2017170130 (†contributed equally).

 

2016

45.  Guorui Jin, Guangxue Feng, Wei Qin, Ben Zhong Tang, Bin Liu,* Kai Li.* Multifunctional organic nanoparticles with aggregation-induced emission (AIE) characteristics for targeted photodynamic therapy and RNA interference therapy. Chem. Commun. 2016, 52, 2752-2755.

46.  Shengjie Peng, Guorui Jin, Linlin Li, Kai Li, Madhavi Srinivasan, Seeram Ramakrishna, Jun Chen. Multi-functional electrospun nanofibres for advances in tissue regeneration, energy conversion & storage, and water treatment. Chem. Soc. Rev. 2016, 45, 1225-1241.

 

2015

47.  Guorui Jin, Duo Mao, Pingqiang Cai, Rongrong Liu, Nikodem Tomczak, Jie Liu, Xiaodong Chen, Deling Kong, Dan Ding,* Bin Liu,* Kai Li.* Conjugated polymer nanodots as ultrastable long-term trackers to understand mesenchymal stem cell therapy in skin regeneration. Adv. Funct. Mater. 2015, 25, 4263-4273 (Frontispiece Story).

48.  Jie Liu, Kai Li,* Bin Liu.* Far-red/near-infrared conjugated polymer nanoparticles for long-term in-situ monitoring of liver tumor growth. Adv. Sci. 2015, 2, 1500008.

49.  Ghayathri Balasundaram, Chris Jun Hui Ho, Kai Li, Wouter Driessen, U. S. Dinish, Chi Lok Wong, Vasilis Ntziachristos, Bin Liu, Malini Olivo. Molecular photoacoustic imaging of breast cancer using an actively targeted conjugated polymer. Inter. J. Nanomedicine 2015, 10, 387-397.

50.  Dan Kai, Zhi Wei Low, Sing Shy Liow, Anis Abdul Karim, Hongye Ye, Guorui Jin, Kai Li, Xian Jun Loh. Development of lignin supramolecular hydrogels with mechanically responsive and self-healing properties. ACS Sustain. Chem. Eng. 2015, 3, 2160-2169.

51.  Lu Peng, Meng Gao, Xiaolei Cai, Ruoyu Zhang, Kai Li, Guangxue Feng, Aijun Tong, Bin Liu. A fluorescent light-up probe based on AIE and ESIPT processes for beta-galactosidase activity detection and visualization in living cells. J. Mater. Chem. B 2015, 3, 9168-9172.

 

2014

52.  Kai Li, Bin Liu. Polymer-encapsulated organic nanoparticles for fluorescence and photoacoustic imaging. Chem. Soc. Rev. 2014, 43, 6570-6597.

53.  Dan Ding,† Duo Mao,† Kai Li,† Xiaomin Wang, Wei Qin, Rongrong Liu, David Shunzhong Chiam, Nikodem Tomczak, Zhimou Yang, Ben Zhong Tang, Deling Kong, Bin Liu. Precise and long-term tracking of adipose-derived stem cells and their regenerative capacity via superb bright and stable organic nanodots. ACS Nano 2014, 8, 12620-12631 (†contributed equally).

54.  Guorui Jin, Kai Li.* The electrically conductive scaffold as the skeleton of stem cell niche in regenerative medicine. Mater. Sci. Eng. C 2014, 45, 671-681 (Invited Review).

55.  Kai Li,† Mie Yamamoto,† Su Jing Chan, Mun Yee Chiam, Wei Qin, Peter Tsun Hon Wong, Evelyn King Fai Yim, Ben Zhong Tang, Bin Liu. Organic nanoparticles with aggregation-induced emission for tracking bone marrow stromal cells in the rat ischemic stroke model. Chem. Commun. 2014, 50, 15136-15139 (Cover Story, †contributed equally).

56.  Wei Qin,† Kai Li,† Guangxue Feng, Min Li, Zhiyong Yang, Bin Liu, Ben Zhong Tang. Bright and photostable organic fluorescent dots with aggregation-induced emission characteristics for noninvasive long-term cell imaging. Adv. Funct. Mater. 2014, 24, 635-643 (†contributed equally).

57.  Guangxue Feng,† Kai Li,† Jie Liu, Dan Ding, Bin Liu. Bright single-chain conjugated polymer dots embedded nanoparticles for long-term cell tracing and imaging. Small 2014, 10, 1212-1219 (†contributed equally).

58.  Junlong Geng, Kai Li, Wei Qin, Ben Zhong Tang, Bin Liu. Red-emissive chemiluminescent nanoparticles with aggregation-induced emission characteristics for in vivo hydrogen peroxide imaging. Part. Part. Syst. Charact. 2014, 31, 1238-1243.

59.  Youyong Yuan, Dan Ding, Kai Li, Jie Liu, Bin Liu. Tumor-responsive fluorescent light-up probe based on gold nanoparticle/conjugated polyelectrolyte hybrid. Small 2014, 11, 1967-1975. (Cover Story)

60.  Zibiao Li, Beng H. Tan, Guorui Jin, Kai Li, Chaobin He. Design of polyhedral oligomeric silsesquioxane (POSS) based thermo-responsive amphiphilic hybrid copolymers for thermally denatured protein protection applications. Poly. Chem. 2014, 5, 6740-6753.

61.  Guangxue Feng, Dan Ding, Kai Li, Jie Liu, Bin Liu. Reversible photoswitching conjugated polymer nanoparticles for cell and ex vivo tumor imaging. Nanoscale 2014, 6, 4141-4147.

 

2013

62.  Kai Li, Wei Qin, Dan Ding, Nikodem Tomczak, Junlong Geng, Rongrong Liu, Jianzhao Liu, Xinhai Zhang, Hongyu Liu, Bin Liu, Ben Zhong Tang. Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing. Sci. Rep. 2013, 3, 1150 (Highlighted by Nature News).

63.  Kai Li, Dan Ding, Prashant Chandrasekharan, Wei Qin, Chang-Tong Yang, Ben Zhong Tang, Bin Liu. Gadolinium-functionalized aggregation-induced emission dots as dual-modality probes for cancer metastasis study. Adv. Healthcare Mater. 2013, 2, 1600-1605.

64.  Kai Li, Zhenshu Zhu, Zujin Zhao, Nikodem Tomczak, Pingqiang Cai, Rongrong Liu, Jie Liu, Wei Qin, Yong Hu, Xiaodong Chen, Ben Zhong Tang, Bin Liu. Organic dots with aggregation-induced emission (AIE dots) characteristics for dual-color cell tracing. Chem. Mater. 2013, 25, 4181-4187.

65.  Kai Li, Dan Ding, QiuLi Zhao, JingZhi Sun, B. Z. Tang, B. Liu. Biocompatible organic dots with aggregation-induced emission for in vitro and in vivo fluorescence imaging. Sci. China Chem. 2013, 56, 1228-1233.

66.  Dan Ding, Kai Li, Bin Liu, Ben Zhong Tang. Bioprobes based on AIE fluorogens. Acc. Chem. Res. 2013, 46, 2441-2453.

67.  Jing Liang, Kai Li, Bin Liu. Visual sensing with conjugated polyelectrolytes. Chem. Sci. 2013, 4, 1377-1394 (Invited Review).

68.  Jie Liu, Kai Li, Junlong Geng, Li Zhou. Prashant Chandrasekharan, Chang-Tong Yang, Bin Liu. Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging. Poly. Chem. 2013, 4, 1517-1524.

69.  Junlong Geng, Kai Li, Wei Qin, Lin Ma, Gagik G. Gurzadyan, Ben Zhong Tang, Bin Liu. Eccentric loading of fluorogen with aggregation-induced emission in PLGA matrix increases nanoparticle fluorescence quantum yield for targeted cellular imaging. Small 2013, 9, 2012-2019.

70.  Dan Ding, Kai Li, Wei Qin, Ruoyu Zhan, Yong Hu, Jianzhao Liu, Ben Zhong Tang, Bin Liu. Conjugated polymer amplified far-red/near-infrared fluorescence from nanoparticles with aggregation-induced emission characteristics for targeted in vivo imaging. Adv. Health. Mater. 2013, 2, 500-507 (Cover Story).

71.  Dan Ding, Jie Liu, Guangxue Feng, Kai Li, Yong Hu, Bin Liu. Bright far-red/near-infrared conjugated polymer nanoparticles for in vivo bioimaging. Small 2013, 9, 3093-3102.

 

2012

72.  Kai Li, Dan Ding, Da Huo, Kan-Yi Pu, Ngo Nguyen Phuong Thao, Yong Hu, Zhi Li, Bin Liu. Conjugated polymer based nanoparticles as dual-modal probes for targeted in vivo fluorescence and magnetic resonance imaging. Adv. Funct. Mater. 2012, 22, 3107-3115.

73.  Kai Li, Bin Liu. Polymer encapsulated conjugated polymer nanoparticles for fluorescence bioimaging. J. Mater. Chem. 2012, 22, 1257-1264.

74.  Junlong Geng,† Kai Li,† Dan Ding, Xinhai Zhang, Wei Qin, Jianzhao Liu, Ben Zhong Tang, Bin Liu. Lipid-PEG-folate encapsulated nanoparticles with aggregation induced emission characteristics: cellular uptake mechanism and two-photon fluorescence imaging. Small 2012, 8, 3655-3663 (†contributed equally).

75.  Qiuli Zhao,† Kai Li,† Sijie Chen, Anjun Qin, Dan Ding, Shuang Zhang, Yi Liu, Bin Liu, Jing Zhi Sun, Ben Zhong Tang. Aggregation-induced red-NIR emission organic nanoparticles as effective and photostable fluorescent probes for bioimaging. J. Mater. Chem. 2012, 22, 15128-15135 (†contributed equally).

76.  Junlong Geng, Kai Li, Kan-Yi Pu, Dan Ding, Bin Liu. Conjugated polymer and gold nanoparticle co-loaded PLGA nanocomposites with eccentric internal nanostructure for dual-modal targeted cellular imaging. Small 2012, 15, 2421-2429.

77.  Jing Liang, Kai Li, Gagik G. Gurzadyan, Xianmao Lu, Bin Liu. Silver nanocube-enhanced far-red/near-infrared fluorescence of conjugated polyelectrolyte for cellular imaging. Langmuir 2012, 28, 11302-11309.

78.  Dan Ding, Guan Wang, Jianzhao Liu, Kai Li, Kan-Yi Pu, Yong Hu, Jason C. Y. Ng, Ben Zhong Tang, Bin Liu. Hyperbranched conjugated polyelectrolyte for dual-modality fluorescence and magnetic resonance cancer imaging. Small 2012, 8, 3523-3530.

79.  Guan Wang, Xinhai Zhang, Junlong Geng, Kai Li, Dan Ding, Liping Cai, Yee-Hing Lai, Bin Liu. Glycosylated star-shaped conjugated oligomers for targeted two-photon fluorescence imaging. Chem. Eur. J. 2012, 18, 9705-9713.

80.  Guan Wang, Junlong Geng, Xinhai Zhang, Liping Cai, Dan Ding, Kai Li, Long Wang, Yee-Hing Lai, Bin Liu. Pyrene-based water dispersible orange emitter for one- and two-photon fluorescence cellular imaging. Polym. Chem. 2012, 3, 2464-2470.

 

2011

81.  Kai Li, Yutao Liu, Kan-Yi Pu, Si-Shen Feng, Ruoyu Zhan, Bin Liu. Polyhedral oligomeric silsesquioxanes-containing conjugated polymer loaded PLGA nanoparticles with Trastuzumab (Herceptin) functionalization for HER2-positive cancer cell detection. Adv. Funct. Mater. 2011, 21, 287-294 (Inside Front Cover Story).

82.  Kai Li, Kan-Yi Pu, Liping Cai, Bin Liu. Phalloidin-functionalized hyperbranched conjugated polyelectrolyte for filamentous actin imaging in living Hela cells. Chem. Mater. 2011, 23, 2113-2119.

83.  Kai Li, Yihua Jiang, Dan Ding, Xinhai Zhang, Yutao Liu, Jianli Hua, Si-Shen Feng, Bin Liu. Folic acid-functionalized two-photon absorbing nanoparticles for targeted MCF-7 cancer cell imaging. Chem. Commun. 2011, 47, 7323-7325 (Back Cover Story).

84.  Kai Li, Ruoyu Zhan, Si-Shen Feng, Bin Liu. Conjugated polymer loaded nanospheres with surface functionalization for simultaneous discrimination of different live cancer cells under single wavelength excitation. Anal. Chem. 2011, 83, 2125-2132.

85.  Yu Mi,† Kai Li,† Yutao Liu, Kan-Yi Pu, Bin Liu, Si-Shen Feng. Herceptin functionalized polyhedral oligomeric silsesquioxane-conjugated oligomers-silica/iron oxide nanoparticles for tumor cell sorting and detection. Biomaterials 2011, 32, 8226-8233 (†contributed equally).

86.  Dan Ding, Kai Li, Zhenshu Zhu, Kan-Yi Pu, Yong Hu, Xiqun Jiang, Bin Liu. Conjugated polyelectrolyte-cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking. Nanoscale 2011, 3, 1997-2002.

87.  Dan Ding, Kan-Yi Pu, Kai Li, Bin Liu. Conjugated oligoelectrolyte-polyhedral oligomeric Silsesquioxane 
loaded pH-responsive nanoparticles for targeted fluorescence imaging of cancer cell nucleus. Chem. Commun. 2011, 47, 9837-9839.

88.  Kan-Yi Pu, Zhentao Luo, Kai Li, Jianping Xie, Bin Liu. Energy transfer between conjugated-oligoelectrolyte-substituted POSS and gold nanocluster for multicolor intracellular detection of mercury ion. J. Phys. Chem. C 2011, 115, 13069-13075.

89.  Kan-Yi Pu, Jianbing Shi, Liping Cai, Kai Li, Bin Liu. Affibody-attached hyperbranched conjugated polyelectrolyte for targeted fluorescence imaging of HER2-positive cancer cell. Biomacromolecules 2011, 12, 2966-2974.

90.  Guan Wang, Kan-Yi Pu, Xinhai Zhang, Kai Li, Long Wang, Liping Cai, Dan Ding, Yee-Hing Lai, Bin Liu. Star-shaped glycosylated conjugated oligomer for two-photon fluorescence imaging of live cells. Chem. Mater. 2011, 23, 4428-4434.

 

2010

91.  Kai Li, Bin Liu. Water-soluble conjugated polymers as the platform for protein sensors. Polym. Chem. 2010, 1, 252-259 (Cover Story).

92.  Kan-Yi Pu,† Kai Li,† Bin Liu. Multicolor conjugate polyelectrolyte/peptide complexes as self-assembled nanoparticles for receptor-targeted cellular imaging. Chem. Mater. 2010, 22, 6736-6741 (†contributed equally).

93.  Kan-Yi Pu, Kai Li, Bin Liu. Cationic oligofluorene-substituted polyhedral oligomeric silsesquioxane as light-harvesting unimolecular nanoparticle for fluorescence amplification in cellular imaging. Adv. Mater. 2010, 22, 643-646.

94.  Kan-Yi Pu, Kai Li, Xinhai Zhang, Bin Liu. Conjugated oligoelectrolyte harnessed polyhedral oligomeric silsesquioxane as light-up hybrid nanodot for two-photon fluorescence imaging of cellular nucleus. Adv. Mater. 2010, 22, 4186-4189.

95.  Kan-Yi Pu, Kai Li, Bin Liu. A molecular brush approach to enhance quantum yield and suppress nonspecific interactions of conjugated polyelectrolyte for targeted far-red/near-infrared fluorescence cell imaging. Adv. Funct. Mater. 2010, 20, 2770-2777.

96.  Yutao Liu, Kai Li, Jie Pan, Bin Liu, Si-Shen Feng. Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of docetaxel. Biomaterials 2010, 31, 330-338.

97.  Yutao Liu, Kai Li, Bin Liu, Si-Shen Feng. A strategy for precision engineering of nanoparticles of biodegradable copolymers for quantitative control of targeted drug delivery. Biomaterials 2010, 31, 9145-9155.

 

2009

98.  Kai Li, Jie Pan, Si-Shen Feng, Arthur Wenqing Wu, Kan-Yi Pu, Yutao Liu, Bin Liu. Generic strategy of preparing fluorescent conjugated polymer-loaded poly(dl-lactide-co-glycolide) nanoparticles for targeted cell imaging. Adv. Funct. Mater. 2009, 19, 3535-3542 (Frontispiece Story).

99.  Kai Li, Bin Liu. Conjugated polyelectrolyte amplified thiazole orange emission for label free sequence specific DNA detection with single nucleotide polymorphism selectivity. Anal. Chem. 2009, 81, 4099-4150.

100.           Kan-Yi Pu, Kai Li, Jianbing Shi, Bin Liu. Fluorescent single-molecular core-shell nanospheres of hyperbranched conjugated polyelectrolyte for live-cell imaging. Chem. Mater. 2009, 21, 3816-3822.

 

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南方科技大学生物医学工程系李凯副教授课题组致力于新型光学分子探针和纳米探针的设计开发及其在干细胞示踪、肿瘤诊疗、生物检测中的应用研究,涉及化学、材料学、生物学、医学等领域的交叉研究,欢迎有志于从事相关科研工作的优秀青年加入课题组共同成长。李凯博士在相关领域有较好的学术积累,发表SCI收录论文总被引大于8000次(Web of Science),其中单篇被引超过100次的论文共15篇,当前H-index为47,详情请参考课题组网页:http://faculty.sustech.edu.cn/lik/
 
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应聘条件:

1.已经取得或近期将取得有机化学、高分子材料、生物学等相关专业的博士学位。
2. 具备较好的有机合成研究背景者优先。
3.具有细胞实验、小动物模型建立和研究背景者优先。
4.有责任心、动手能力强、勤勉努力、富有团队合作精神,具有良好的实验安全意识以及一定的独立科研能力。
5.已在相关研究领域取得一定的科研成果,有高质量的SCI论文,在top学术期刊发表或被正式接收。
6.具备良好的文献查阅和英文论文写作能力。
 
岗位待遇:
1、博士后聘用期两年,年薪33万元起,含广东省生活补助15万元及深圳市生活补助6万元,并按深圳市有关规定参加社会保险及住房公积金。博士后福利费参照学校教职工标准发放。  
2、特别优秀候选人可以申请校长卓越博士后,年薪可达50万元以上。(含广东省及深圳市在站生活补贴)。
3、在站期间,可依托学校申请深圳市公租房,未依托学校使用深圳市公租房的博士后,可享受两年税前2800元/月的住房补贴。
4、拥有优良的工作环境和境内外合作交流机会,博士后在站期间享受两年共计2.5万学术交流经费资助。
5、课题组协助符合条件的博士后申请“广东省海外青年博士后引进项目”。即在世界排名前200名的高校(不含境内,排名以上一年度泰晤士、USNEWS、QS和上海交通大学的世界大学排行榜为准)获得博士学位,在广东省博士后设站单位从事博士后研究,并承诺在站2年以上的博士后,申请成功后省财政给予每名进站博士后资助60万元生活补贴(与广东省每年15万生活补贴不同时享受,与深圳市每年6万元生活补贴同时享受情况以深圳市规定为准);对获得本项目资助,出站后与广东省用人单位签订工作协议或劳动合同,并承诺连续在粤工作3年以上的博士后,省财政给予每人40万元住房补贴。
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2 岗位:科研助理












应聘条件:
1.化学、材料学、生物学、生物医学工程等相关专业的优秀本科或硕士毕业生。
2. 已发表SCI论文者优先。
3.工作认真负责、动手能力强、勤勉努力、积极进取、富有团队合作精神,具备扎实的实验技能。
4.具备良好的英文读写能力。
 

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