助理教授 |生命科学学院, 系统生物学系
梁征宇2012年本科毕业于华中科技大学生物信息技术专业,2018年博士毕业于清华大学生物学专业(导师张奇伟教授),2018-2023年于加州大学圣地亚哥分校细胞与分子医学系从事博士后研究(导师付向东教授),于2023年4月全职回国加入南方科技大学生命科学学院,担任助理教授,博士生导师,独立课题组长(PI)。
梁征宇博士致力于功能基因组学的研究,运用生物信息学及细胞和分子生物学方法,研究基因组三维空间结构、基因转录调控、RNA代谢及功能等系列科学问题,特别是研究肿瘤中染色体外DNA(extrachromosomal DNA)的结构与功能,以第一作者(含共同)身份在Cell、Circulation、Nature Communication、Cell Reports等国际期刊上发表研究论文多篇。
个人简介
个人简介
研究领域
◆ 三维基因组的检测技术开发和功能研究
◆ 转录调控机制研究
◆ RNA代谢及参与基因组功能研究
◆ 肿瘤中染色体外DNA的结构与功能研究
学术成果 查看更多
- Xiao, R.*, Chen, J.-Y.*, Liang, Z.*, Luo, D., Chen, G., Lu, Z.J., Chen, Y., Zhou, B., Li, H., and Du, X. (2019). Pervasive chromatin-RNA binding protein interactions enable RNA-based regulation of transcription. Cell 178, 107-121. e118.
- Liang, Z., Li, G., Wang, Z., Djekidel, M.N., Li, Y., Qian, M.-P., Zhang, M.Q., and Chen, Y. (2017). BL-Hi-C is an efficient and sensitive approach for capturing structural and regulatory chromatin interactions. Nature communications 8, 1622.
- Liang, Z., and Fu, X.-D. (2021). 3D genome encoded by LINE and SINE repeats. Cell Research 31, 603-604.
- Wu, T.*, Liang, Z.*, Zhang, Z., Liu, C., Zhang, L., Gu, Y., Peterson, K.L., Evans, S.M., Fu, X.-D., and Chen, J. (2022). PRDM16 is a compact myocardium-enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle. Circulation 145, 586-602.
- Song, Y.*, Liang, Z.*, Zhang, J.*, Hu, G.*, Wang, J., Li, Y., Guo, R., Dong, X., Babarinde, I.A., and Ping, W. (2022). CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming. Cell Reports 39, 110626.
- Qian, H., Kang, X., Hu, J., Zhang, D., Liang, Z., Meng, F., Zhang, X., Xue, Y., Maimon, R., and Dowdy, S.F. (2020). Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 582, 550-556.
- Gou, L.-T., Lim, D.-H., Ma, W., Aubol, B.E., Hao, Y., Wang, X., Zhao, J., Liang, Z., Shao, C., and Zhang, X. (2020). Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1-catalyzed protamine phosphorylation. Cell 180, 1212-1227. e1214.
- Qiu, Z., Zhao, L., Shen, J.Z., Liang, Z., Wu, Q., Yang, K., Min, L., Gimple, R.C., Yang, Q., and Bhargava, S. (2022). Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem CellsTargeting Transcription Machinery Potentiates Immunotherapy. Cancer discovery 12, 502-521.
- Zhu, S., Nguyen, A., Pang, J., Zhao, J., Chen, Z.e., Liang, Z., Gu, Y., Huynh, H., Bao, Y., and Lee, S. (2022). Mitochondrial Stress Induces an HRI-eIF2α Pathway Protective for Cardiomyopathy. Circulation 146, 1028-1031.