Sheng-Jian Ji

Associate Professor with Tenure |School of Life Sciences, Department of Biology

Dr. Ji is currently an associate professor with tenure at Department of Biology, School of Life Sciences. He also serves as Associate Dean for Academic Affairs at Shude College. Dr. Ji has mainly focused on developmental neurobiology. He is primarily interested in elucidating mechanisms regulating neuronal development by different signal pathways including retrograde signals derived from target tissues of axon. He also made progresses on studying the roles of local protein synthesis in axons and mRNA modification during neuronal development.

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Novel mechanisms regulating neural development and functions:


◆ mRNA modification


◆ Local mRNA translation in axons


◆ Retrograde signaling from axonal terminal to soma


Neurobiology (Undergraduate)

Cellular and Molecular Neurobiology (Graduate)

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Selected publications (*corresponding author;#equal contribution

  1. Fugui Niu, Peng Han, Jian Zhang, Yuanchu She, Lixin Yang, Jun Yu, Mengru Zhuang, Kezhen Tang, Yuwei Shi, Baisheng Yang, Chunqiao Liu, Bo Peng*, Sheng-Jian Ji*. The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells. eLife 2022, 11: e75827. DOI: 10.7554/eLife.75827 (online Feb 18, 2022).
  2. Hengjun Huang, Gaopu Zhang, Gui-Xin Ruan, Yuxing Li, Wenjing Chen, Jia Zou, Rui Zhang, Jing Wang, Sheng-Jian Ji*, Shengli Xu, Xijun Ou*. Mettl14-mediated m6A modification is essential for germinal center B cell response. Journal of Immunology 2022, 208(8): 1924-1936. Published online April 1, 2022.
  3. Lichao Li#, Jun Yu#Sheng-Jian Ji*. Axonal mRNA localization and translation: local events with broad roles. Cellular and Molecular Life Sciences (In press)
  4. Jun Yu#, Yuanchu She#, Lixin Yang#, Mengru Zhuang, Peng Han, Jianhui Liu, Xiaoyan Lin, Nijia Wang, Mengxian Chen, Chunxuan Jiang, Yujia Zhang, Yujing Yuan, Sheng-Jian Ji*. The m6A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons. Advanced Science 2021, doi:10.1002/advs.202101329. Published Oct 12, 2021.
  5. Jun Yu, Yuanchu She, Sheng-Jian Ji*. m6A modification in mammalian nervous system development, functions, disorders and injuries. Frontiers in Cell and Developmental Biology 2021, 9: 679662.
  6. Mengru Zhuang, Xinbei Li, Junda Zhu, Jian Zhang, Fugui Niu, Fanghao Liang, Mengxian Chen, Duo Li, Peng Han, Sheng-Jian Ji*. The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression. Nucleic Acids Research 2019, 47(9): 4765-4777. Published online Mar 7, 2019.
  7. Jun Yu#, Mengxian Chen#, Haijiao Huang#, Junda Zhu, Huixue Song, Jian Zhu, Jaewon Park, Sheng-Jian Ji*. Dynamic m6A modification regulates local translation of mRNA in axons. Nucleic Acids Research 2018, 46(3): 1412-1423. Published online Nov 23, 2017.
  8. Sheng-Jian Ji, Samie R. Jaffrey*. Axonal transcription factors: Novel regulators of growth cone-to-nucleus signaling. Developmental Neurobiology 2014, 74(3): 245-258. 
  9. Dilek Colak, Sheng-Jian Ji, Bo Torben Porse, Samie R. Jaffrey*. Regulation of axon guidance by nonsense-mediated mRNA decay. Cell 2013, 153(6): 1252-1265. 
  10. Sheng-Jian Ji, Samie R. Jaffrey*. Intra-axonal translation of SMAD1/5/8 mediates retrograde regulation of trigeminal ganglia subtype specification. Neuron 2012, 74(1): 95-107. 
  11. Breset A. Walker#Sheng-Jian Ji#, Samie R. Jaffrey*. Intra-axonal translation of RhoA promotes axon growth inhibition by CSPG. Journal of Neuroscience 2012, 32(41): 14442-14447. 
  12. Sheng-Jian Ji, Goran Periz, Shanthini Sockanathan*. Nolz1 is induced by retinoid signals and controls motoneuron subtype identity through distinct repressor activities. Development 2009, 136 (2): 231-240.
  13. Sheng-Jian Ji#, Binquan Zhuang#, Crystal Falco, André Schneider, Karin Schuster-Gossler, Achim Gossler, Shanthini Sockanathan*. Mesodermal and neuronal retinoids regulate the induction and maintenance of forelimb spinal motor neuron subtype identity. Developmental Biology 2006, 297(1): 249-261. 
  14. Sheng-Jian Ji, Ying-Chun Lu, Jian-Xun Feng, Gang Wei, Jun Li, Yong-Hui Shi, Qiang Fu, Di Liu, Jing-Chu Luo, Yu-Xian Zhu*. Isolation and analyses of genes preferentially expressed during early cotton fiber development by subtractive PCR and cDNA array. Nucleic Acids Research 2003, 31(10): 2534-2543.
  15. Sheng Jian Ji, Feng Liu, Er Qiu Li, Yu Xian Zhu*. Recombinant scorpion insectotoxin AaIT kills specifically insect cells but not human cells. Cell Research 2002, 12(2): 143-150.
  16. Shengjian Ji, Yingchun Lu, Jun Li, Gang Wei, Xiujuan Liang, Yuxian Zhu*. A b-tubulin-like cDNA expressed specifically in elongating cotton fibers induces longitudinal growth of fission yeast. Biochemical and Biophysical Research Communications 2002, 296(5): 1245-1250.

News More

  • Celebrate Teachers' Day and welcome new members and senior members with new titles!

  • New progress on RNA modification regulating retinal development and functions

  • Congratulations, Dr. Zhuang!


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