Associate Professor |School of Life Sciences, Department of Biology
Dr. Wenfei Jin is an Associate Professor (PI) in Department of Biology in Southern University of Science and Technology (SUSTech). He has worked on population genetics and precision medicine related field since his Ph.D. program. He has published >30 research articles and book chapters, including first author and corresponding author articles on Nature, Nat Methods, Genome Res, AJHG and Genome Biol. He and his colleagues developed single cell DNase-seq that provides key regulatory information for precision medicine (Jin, et.al, 2015 Nature).
Dr. Wenfei Jin received his bachelor’s degree from Zhengzhou University in 2006. He received his Ph.D. in Computational biology from Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB) with Prof. Li Jin (CAS member) and Prof. Shuhua Xu in 2012. Dr. Jin completed his Postdoc Fellow in systems biology in National Institutes of Health (NIH) with Dr. Keji Zhao in 2017. Dr. Jin is the recipient of many honors and awards including Springer Theses, CAS Excellent Doctoral Dissertation and NHLBI Orloff Award. Dr. Jin is especially interested in promoting the applications of single cell sequencing in clinical diagnosis and medical consultation.
Dr. Jin is interested in 1) single cell sequencing and its applications in cancer biology; 2) bioinformatics and identifying genetic/epigenetic changes that drive oncogenesis; 3) developing cancer prediction and treatment model for precision medicine.
Personal Profile
Dr. Wenfei Jin is an Associate Professor (PI; PhD supervisor;Tenure Track) in Department of Biology in Southern University of Science and Technology (SUSTech). Dr. Jin received his bachelor's degree from Zhengzhou University in 2006. He received his Ph.D. in Computational biology from Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB) with Prof. Li Jin (CAS member) and Prof. Shuhua Xu in 2012. Dr. Jin completed his Postdoc Fellow in systems biology at National Institutes of Health (NIH) with Dr. Keji Zhao in 2017. He joined in Southern University of Science and Technology (SUSTech) in 2017. Dr. Jin works on population genetics and precision medicine related field since his Ph.D. program. He has published >20 research articles and book chapters, including first/co-fist author articles on Nature, AJHG, Genome Res, Genome Biol and HMG. Dr. Jin and his colleagues developed single cell DNase-seq (scDNase-seq) that could provide key regulatory information for precision medicine (Jin, et.al, 2015 Nature). Dr. Jin is the recipient of many honors and awards including Springer Theses, CAS Excellent Doctoral Dissertation and NHLBI Orloff Award. Dr. Jin is especially interested in promoting the applications of single cell sequencing in clinical diagnosis and medical consultation.
Research interests
Dr. Jin’s lab is interested in identifying genetic/epigenetic changes that drive oncogenesis, and developing disease risk prediction model for precision medicine. The long-term goal of the lab is to develop efficient personalized treatment for cancers based on patients’ genetic background. In near future, the lab will focus on investigating genetic/epigenetic heterogeneity and micro-evolution of cancer cells using single cell sequencing related technologies.
Professional Experience
Mar.2017-present Associate Professor, Southern University of Science and Technology
Jan.2013-Mar.2017 Postdoc fellow, National Institutes of Health (NIH)
Mentor: Dr. Keji Zhao
Jan.2012-Dec.2012 Assistant researcher, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB), SIBS, CAS
Education
Sept.2006-Dec.2011 Ph.D. in Computational Biology, PICB and University of Chinese Academies of Sciences
Supervisors: Prof. Felix Li Jin (CAS member) and Dr. Shuhua Xu
Feb.2006-April.2006 Intern, Institute of Biochemistry and Cell Biology, SIBS, CAS
Mentors: Prof. Mofang Liu and Prof. Enduo Wang (CAS member)
Sept.2001-July.2006 B.Sc. in Biotechnology, Zhengzhou University, China
Awards and Honors
2019 Pearl River Youth Talents, Guangdong
2018 Outstanding Advisor of College, Zhixin College, SUSTech
2018 National level leading expert, Shenzhen
2017 Shenzhen Peacock Plan B
2017 Distinguished Scientist Award, NIH-CSSA
2016 Orloff innovation Awards, NHLBI, USA
2016 Fellows Award for Research Excellence (FARE), NIH, USA
2014 Springer Theses, Springer
2013 Excellent Doctoral Dissertation, Chinese Academy of Sciences
2012 First-author Awards, PICB
2012 Outstanding Graduate Award, University of Chinese Academy of Sciences
2012 SIBS-Eli Lilly Outstanding Ph.D. Thesis Awards, Eli Lilly
2011 Travel Awards, 12th International Congress of Human Genetics (ICHG)/61th ASHG
2011 Pfizer Awards, Shanghai Institutes for Biological Sciences
2010 Di’ao scholarship Awards, Chinese Academy of Sciences
Research
The long-term goal of Jin lab is developing precision diagnosis and treatment for cancers. Currently, our lab mainly works on designing single cell multi-omics approaches to address questions in development and medicine, particularly focus on:
1) Developing single cell sequencing to study tumor microenvironment and model tumor development
2) Investigating the cellular heterogeneity and its mechanism via single cell technology
Teaching
Courses:
Computational Biology
Bioinformatics
Genomics Data Analysis
Publications Read More
Selected Representative Publications from 40 papers (#equal contribution; * corresponding author)
18. Preprint: Xu W#, Yang W#, Zhang Y, Chen Y, Zhang Q, Wang X, Song K, Jin W*, Chen X*. ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells. Biorxiv. 476488. doi: https://doi.org/10.1101/2022.01.16.476488
17. Preprint: Wang J#, Chen W#, Hou W, Hong N, Zhong H, Ni T*, Qi Y*, Jin W*. Comprehensive mapping of the alternative polyadenylation site usage and its dynamics at single cell resolution. Biorxiv. 471022. doi: https://doi.org/10.1101/2021.12.02.471022
16. Wang X#, Shen X#, Chen S, Liu H, Hong N, Zhong H, Chen X, Jin W*. (2022) Reinvestigation of Classic T Cell Subsets and Identification of Novel Cell Subpopulations by Single-Cell RNA Sequencing. J Immunol. 208(2):396-406. https://doi.org/10.4049/jimmunol.2100581
15. Yi G, Lin Y, Lin C, Jin W*. (2021) Kssd: sequence dimensionality reduction by k-mer substring space sampling enables real-time large-scale datasets analysis. Genome Biol. 22:84. doi: 10.1186/s13059-021-02303-4
14. Qin P#, Pang Y#, Hou W#, Fu R#, Zhang Y#, Wang X#, Meng G, Liu Q, Zhu X, Hong N*, Cheng T* and Jin W* (2021) Integrated decoding hematopoiesis and leukemogenesis using single cell sequencing and its medical implication. Cell Discov. 7:2. doi: 10.1038/s41421-020-00223-4
13. Hou W#, Duan L#, Huang C#, Li X, Xu X, Qin P, Hong N, Wang D*, Jin W*. (2021) Cross-Tissue Characterization of Heterogeneities of Mesenchymal Stem Cells and Their Differentiation Potentials. Front Cell Dev Biol. 9:781021. doi:https://doi.org/10.3389/fcell.2021.781021
12. Fu R, Qin P, Zou X, Hu Z, Hong N*, Wang Y* and Jin W* (2021) A Comprehensive Characterization of Monoallelic Expression During Hematopoiesis and Leukemogenesis via Single-Cell RNA-Sequencing. Front Cell Dev Biol. 9:702897. doi: 10.3389/fcell.2021.702897
11. Han Z, Cui K, Placek K, Hong N, Lin C, Chen W, Zhao K*, Jin W*, (2020) Diploid genome architecture revealed by multi-omic data of hybrid mice. Genome Res. 30:1097-1106.
10. Wang W, Ren G, Hong N*, Jin W*. (2019) Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq. BMC Genomics. 20:1015. doi: 10.1186/s12864-019-6379-5.
9. Lai B#, Tang Q# Jin W#, Hu G#, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. (2018). Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 15:741-747.
8. Lai B, Gao W, Cui K, Xie W, Tang Q, Jin W, Hu G, Ni B, Zhao K. (2018) Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing. Nature. 562:281-285
7. Ren G#, Jin W#, Cui K, Rodrigez J, Hu G, Zhang Z, Larson DR, Zhao K. (2017). CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression. Mol Cell 67: 1049-1058.
6. Jin W#, Tang Q#, Wan M, Cui K, Zhang Y, Ren G, Ni B, Sklar J, Przytycka T, Childs R, Levens D, Zhao K. (2015) Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples. Nature. 528:142-146
5. Jin W#, Li R#, Zhou Y, Xu S. (2014) Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping. Euro J Hum Genet. 22:930-937.
4. Kraushaar DC#, Jin W#, Maunakea A, Abraham B, Ha M, Zhao K. (2013) Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3. Genome Biol. 14:R121.
3. Jin W, Wang S, Wang H, Jin L, Xu S. (2012) Exploring population admixture dynamics via empirical and simulated genome-wide distribution of ancestral chromosomal segments. Am J Hum Genet. 91:849-862.
2. Jin W, Qin P, Lou H, Jin L, Xu S. (2012) A systematic characterization of genes underlying both complex and Mendelian diseases. Hum Mol Genet. 21: 1611-1624.
1. Jin W, Xu S, Wang H, Yu Y, Shen Y, Wu B, Jin L. (2012) Genome-wide detection of natural selection in African Americans pre- and post-admixture. Genome Res. 22:519-527.
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Lab members Read More
Join us
We are seeking highly motivated postdoctoral fellows, PhD students, graduate students and interns with interesting in single cell sequencing and precision medicine to join our lab. Dr. Wenfei Jin’s lab in the Southern University of Science and Technology is interested in 1) single cell sequencing and its applications in cancer biology; 2) identifying genetic/epigenetic changes that drive oncogenesis; 3) developing cancer prediction and treatment model for precision medicine. The long-term goal of the lab is to develop efficient personalized treatment for cancers based on patients’ genetic background. In near future, the lab will focus on investigating genetic/epigenetic heterogeneity and micro-evolution of cancer cells using single cell sequencing related technologies. The lab is well funded by multiple programs including "National Key R&D Program" and "National Science Foundation of China (NSFC)".
- Postdoc’s annual total salary usually is about 330,000 RMB(48,000 USD) per year, (Applicants should have a track-record of high quality publications).
- Scholarship is highly competitive (about >80,000 RMB per year for PhD student; about >40,000 RMB per year for graduate student)
- Stipends for intern will depends on applicant’s performance.
Contact
If you are interested in joining Dr. Jin’s lab, please send your C.V. and the names of 2-3 references to Dr. Jin (jinwf@sustech.edu.cn). We look forward to hearing from you!
Contact Us
Contact Address
1088 Xueyuan Avenue # Faculty Research Building NO.1, Room 206
Office Phone
(+86) 0755-88018478
jinwf@@sustech.edu.cn