Associate Professor Department of Biology

Dr Ancheng Huang obtained his Ph.D. degree in natural product chemistry from The University of Adelaide, Australia, in December 2014, receiving the 'Dean's Commendation for Doctoral Thesis Excellence'. After a short post-doc stay with Professor Zhi-hong Jiang (PVC) at the State Key Laboratory of Quality Research in Chinese Medicine in Macau University of Science and Technology, Dr Huang moved to the John Innes Centre, UK, working on natural product biosynthesis under the supervision of Professor Anne Osbourn (FRS) in 2015 with the support of a Marie Curie Individual Fellowship. He returned to China and joined the Department of Biology in SUSTech as an Assistant Professor in August 2019. Dr Huang’s research is centered on the interface of plant chemistry and biology, with a particular focus on natural product biosynthesis. His team employs multi-disciplinary approaches ranging from chemistry and genetics to bioinformatics to address fundamental questions concerning how and why natural products are made in nature and mechanisms underpinning enzyme catalysis. We translate the knowledge we learned from natural product biosynthesis into developing production platforms for high-value natural products using synthetic biology.

Personal Profile

Research

◆ Plant specialized metabolism

◆ Natural product biosynthesis-pathway discovery and elucidation

◆ Synthetic biology and metabolic engineering

◆ Mechanisms concerning enzyme-mediated catalysis and protein engineering

◆ Metabolomics


Publications Read More

Selected Publication:

[20] Yu, J.; Tu, X.; Huang, A.C.*Functions and biosynthesis of plant signaling metabolites mediating plant-microbe interactions. Natural Product Reports, 2022, in press.

[19] Luo, F.#; Yu, Z.#; Zhou, Q. Huang, A.C.*Multi-Omics-Based Discovery of Plant Signaling Molecules. Metabolites, 2022, 12, 76.

[18] Hong, Y.#; Zhou, Q.#; Hao, Y.; Huang, A.C.Crafting the plant root metabolome for improved microbe-assisted stress resilience. New Phytologist, 2022, 234(6), 1945-1950.

[17] Liu, Xin; Jing Fu; Ji Yang; Ancheng C. Huang; Run-Feng Li; Li-Ping Bai; Liang Liu; Zhi-Hong Jiang; and Guo-Yuan Zhu. Linderaggrenolides A–N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera Aggregata. ACS Omega2021, 6(8): 5898–5909. https://doi.org/10.1021/acsomega.0c06349.

[16] Bai, Y; Calvo, P. F.; Ritter, A.; Huang, A.C.; Herrera, S.M.; Bicalho, K.U.; Karady, M.; Pauwels, L.; Buyst, D.; Njo, M.; Ljung, K.; Martins, J.C.; Vanneste, S.; Beeckman, T.; Osbourn, A.; Goossens, A.; Pollier, J. Modulation of Arabidopsis root growth by specialized triterpenes. New Phytologist, 2020, doi:10.1111/nph.17144

[15] Zhou, Q.; Huang, A.C.* Recent progress on modulation of microbiota by plant root metabolites. Plant Physiology Journal. 2020, 56(11):2288-2295. [(In Chinese) 周倩,黄安诚*. 植物根系化合物调控微生物菌群研究进展.植物生理学报.2020, 56(11):2288-2295]

[14] Huang, A.C.#; Chen,C.Y.#; Wang, J.Y.; Jiang, Z.H. Three new C21 steroidal glycosides from Tylophora atrofolliculata. Phytochemistry Letters, 2020, 36, 111-114 (# Co-first author)

[13] Huang, A.C.#; Jiang, T.#; Liu, Y.X.; Bai, Y.C.; Reed, J.; Qu, B; Goossens, A.; Nutzmann, H.-W.; Bai, Y.; Osbourn, A. A specialized metabolic network selectively modulates Arabidopsis root microbiota. Science, 2019, 364(6440): eaau6389. (# Co-first author)

[12] Huang, A.C., Osbourn, A. Plant terpenes that mediate below‐ground interactions: prospects for bioengineering terpenoids for plant protection. Pest Management Science, 2019, 75(9), 2368-2377.

[11] Huang, A.C.; Hong, Y. J.; Bond, A. D.; Tantillo, D. J.; Osbourn, A. Diverged terpene synthases reroute the carbocation cyclization path towards the formation of unprecedented 6/11/5 and 6/6/7/5 sesterterpene scaffolds. Angewandte Chemie International Edition, 2018, 57(5), 1291-1295.

[10] Xue Z.; Tan Z.; Huang A.; Zhou Y.; Sun J.; Wang X.; Thimmappa R. B.; Stephenson M. J.; Osbourn A.; Qi X. Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species. New Phytologist. 2018, 218(3):1076-1088.

[9] Huang, A.C.; Kautsar S. A..; Hong, Y. J.; Bond, A. D.; Madema M. H.; Tantillo, D. J.; Osbourn, A. Unearthing a sesterterpene biosynthetic repertoire in the Brassicaceae through genome mining reveal convergent evolution. Proceedings of the National Academy of Science, U.S.A., 2017, 114(29), E6005-6014.

[8] Owen C.; Patron N. J.; Huang A.; Osbourn A. Harnessing plant metabolic diversity. Current Opinion in Chemical Biology, 2017, 40, 24-30.

[7] Nützmann H.-W.; Huang A.; Osbourn A. Plant metabolic clusters-from genetics to genomics. New Phytologist. 2016, 211(3), 711-789.

[6] Huang, A.-C.; Sefton, M. A.; Sumby, C. J.; Tiekink, E. R.T.; Taylor, D. K. Mechanistic studies on the autoxidation of a-guaiene: The structural diversity of the sesquiterpenoid downstream products. Journal of Natural Products, 2015, 78, 131-145.

[5] Davies, C; Böttcher, C; Nicholson, E. L.; Burbidge, C. A.; Bastian, S; Harvey, K. E.; Huang, A.-C.; Taylor, D. K.; Boss, P. K. Shiraz wines made from grape berries (Vitis vinifera) delayed in ripening by plant growth regulator treatment have elevated rotundone levels and ‘pepper’ flavor and aroma. Journal of Agricultural and Food Chemistry, 2015, 63(8), 2137-2144.

[4] Huang, A.-C.; Sefton, M. A.; Taylor, D. K. Comparison of the formation of peppery and woody sesquiterpenes derived from aguaiene and a-bulnesene under aerial oxidative conditions. Journal of Agricultural and Food Chemistry, 2015, 63(8), 2137-2144

[3 Huang, A.-C.; Sumby, C. J.; Tiekink, E. R.T.; Taylor, D. K. Synthesis of guaia-4(5)-en-11-ol, guaia-5(6)-en-11-ol, aciphyllene, 1-epi-melicodenone C and E and other guaiane-type sesquiterpenoids via the diastereoselective epoxidation of guaiol. Journal of Natural Products, 2014, 77(11), 2522-2536.

[2] Huang, A.-C.; Burrett, S.; Sefton, M. A.; Taylor, D. K. Production of the pepper aroma compound, (-)-rotundone by aerial oxidation of α-guaiene. Journal of Agricultural and Food Chemistry, 2014, 62 (44), 10809–10815.

[1] Huang, A.-C.; Wilde, A.; Ebmeyer, J.; Skouroumounis, G. K.; Taylor, D. K. Examination of the phenolic profile and antioxidant activity of the leaves of the Australian native plant Smilax glyciphylla. Journal of Natural Products, 2013, 76 (10), 1930-1936.

Authored Books

 [1] Huang, A.C.*; Nützmann, H.-W*. Chromatin Analysis of Metabolic Gene Clusters in 

 Plants. Method in Molecular Biology, 2020, 2093, 129-146. (*Co-corresponding author)

News More

  • 2019 Undergraduate Commencement for SUSTech College of Life and Health Sciences

    2019-11-04
  • SUSTech Annual Research Symposium 2019 comes to a successful close

    2019-11-04
  • SUSTech approved for four new post-doctoral research stations

    2019-11-04

Lab members Read More

Join us

We have postdoc positions open constantly. We are looking for talented postdocs with natural product chemistry , analytical chemistry, bioinformatics, metabolomics and/or genetics backgrounds and interested in working on plant specialized metabolisms. Please contact Dr Huang directly for inquiry (huangac@sustech.edu.cn).

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Contact Us

Contact Address

Room 337, Research Building 1, Southern University of Science and Technology 1088 Xueyuan Avenue, Nanshan District, Shenzhen 518055, P.R. China

Office Phone

0755-88018496

Email

huangac@sustech.edu.cn

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