Dr. Shengtao Hou is a Professor of Neurobiology. He is the Founding Director for SUSTech Brain Research Center, Executive Director for SUSTech Institute of Neuroscience. He is also the Deputy Chair for the Department of Biology and Founding Director for SUSTech Global Engagement Office. He received his doctoral degree from the Faculty of Medicine, University of Glasgow in 1991. After completing his postdoctoral trainings at King’s College London (1991-1993) and the Department of Biochemistry, University of Bristol (1993-1996), Dr. Hou was recruited by the National Research Council of Canada as an Assistant Research Officer in May 1996. Since then, Dr Hou has risen to the rank of Group leader, Senior Research Officer (tenured position, since 2005). He is also an Adjunct full Professor at the Department of Biochemistry, Immunology and Microbiology of the University of Ottawa (since 2002) to train doctoral and postdoctoral students. Professor Hou’s research is focused on identifying novel molecular targets in the complex cascade of post stroke brain and developing novel experimental strategies and drugs relevant to clinical therapeutics.

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Professor Hou’s research is focused on identifying novel molecular targets in the complex cascade of post stroke brain and developing novel experimental strategies and drugs relevant to clinical therapeutics.


BIO311-14 Animal Physiology (3rd Yr)

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1. Zheng, L., Yu, M., Lin, R., Wang, Y., Zhuo, Z., Cheng, N., Wang, M., Tang, Y., Wang, L., Hou, S.-T. * (2020). Rhythmic light flicker rescues hippocampal low gamma and protects ischemic neurons by enhancing presynaptic plasticity. Nat Commun 11, 3012.

2. Lifeng Zheng, Chengbin Xie, Ju Zheng, Qiangrui Dong, Tengxiao Si, Jing Zhang, and Sheng-Tao Hou* (2020) An imbalanced ratio between PC(16:0/16:0) and LPC(16:0) revealed by lipidomics supports the role of the Lands’ cycle in ischemic brain injury. J. Biol. Chem. jbc.RA120.016565. doi:10.1074/jbc.RA120.016565.

3. Yu M, Chen X, Liu J, Ma Q, Zhuo Z, Chen H, Zhou L, Yang S, Zheng L, Ning C, Xu J, Gao T, Hou ST* (2019)Gallic acid disruption of Aβ1-42 aggregation rescues cognitive decline of APP/PS1 double transgenic mouse. Neurobiol Dis 124:67-80.

4. Hou ST*, Jiang SX, Zaharia L, Han X, Benson CL, Slinn J, Abrams SR (2016)Phaseic Acid, an Endogenous and Reversible Inhibitor of Glutamate Receptors in Mouse Brain. J Biol Chem. 291(53):27007-27022.

5. Zhang WD, Hou ST, Stanimirovic D (2015) Blood Brain Barrier Protection in Stroke: Taming tPA. In Chapter 10, “The blood-Brain Barrier in Health and Disease, Vol II: Pathophysiology and Pathology”. (Ed: Dorovini-Zis, K. Pages 394), CRC Press pp. 226-246.

6. Hou ST* (2013) Neuronal Guidance. In “Encyclopedia of Genetics” (Sydney Brenner Ed). Academic Press. 1138-1140.

7. Jiang SX, Whitehead S, Aylsworth A, Slinn J, Zurakowski B, Chan K, Li J, Hou ST*. (2010) Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons. J Biol Chem. 285:9908-18.

8. Jiang SX, Sheldrick M, Desbois A, Slinn J, Hou ST* (2007) Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo. Mol Cell Biol. 27:1696-1705.

9. Hou, ST*, Jiang SX, Desbois D, Huang DQ, Kelly J, Tessier L, Karchewski L, Kappler J (2006) Calpain-Cleaved Collapsin Response Mediator Protein-3 Induces Neuronal Death after Glutamate Toxicity and Cerebral Ischemia. J Neurosci 26: 2241-2249.

10. Jiang SX, Lertvorachon J, Hou ST*, Konishi Y, Webster J, Mealing G, Brunette E, Tauskela J, Preston E. (2005) Chlortetracycline and demeclocycline protect mouse neurons agasint glutamate toxicity and cerebral ischemia through inhibition of calpain. J Biol Chem 280:33811-33818.

11. Weaver JGR, Tarze A, Moffat TC,…Kroemer R, Hou ST, Bennett SAL, Lynch DH, Kroemer G, Badley AD. (2005) Inhibition of Adenine Nucleotide Translocator Pore Function and Protection Against Apoptosis in vivo by an HIV Protease Inhibitor. J Clin Invest 115:1828-1838.

12. Hou,ST*. Xie,X., Baggley,A., Park,D.S., Chen,G., and Walker,T. (2002) Activation of the Rb/E2F1 pathway by the non-proliferative p38 MAP kinase during Fas (APO1/CD95)-mediated neuronal apoptosis. J Biol Chem. 277, 48764-48770.

13. O’Hare, M.J., Hou, ST., Morris, E.J., Cregan, S.P., Xu, Q., Slack, R.S., Park, D.S. (2000) Induction and modulation of cerebellar granule neuron death by E2F-1. J Biol Chem. 275:25358-64.

14. Giovanni, A., Keramaris, E., Morris, E.J., Hou, ST., O’Hare, M., Dyson, N., Robertson, G.S., Slack, R.S., Park, D.S. (2000) E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3. J Biol Chem. 275:11553-60.

15. Tu, Y*., Hou, S.T.*, Huang, Z., Robertson, G.S., MacManus, J.P. (1998) Increased Mdm2 expression in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1998 18:658-69. (co-first author).

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Welcome to the Department of Biology! Since its establishment in 2012, the Department of Biology has attracted internationally renowned professors to join as leaders and dozens of young scientists to start their independent academic career here pursuit of excellence in research and teaching. The research interests of our faculty members include diverse topics such as cell biology, neuro biology, plant biology & food safety, bioinformatics, systems biology, structural biology and biophysics. The primary goals of our faculty are to address the most significant fundamental biological questions and to develop new strategies to treat various complex diseases. Such efforts will benefit from the shared inter-disciplinary collaborative spirit deeply rooted in the minds of all the faculty members working in different departments at SUSTech.


Mentoring the next generation biologists with the highest standards is another primary task of the Department of Biology. Our professors choose internationally acclaimed textbooks to teach core courses biological sciences, biotechnology and bioinformatics. Undergraduates are encouraged to join the laboratory early to get firsthand working experience in basic and/or applied biological research, which helps them to consolidate the mastering of basic techniques, to broaden their knowledge horizons and to acquire the capabilities of problem identifying, hypothesis formulating and problem solving.


Life science, one of the fastest developing natural scientific disciplines, has been the driving force behind the growth of the world economy and provides the know for the development of new technologies serving to improve the human health and welfare at large. Wit generous financial support from the Shenzhen municipal government, we are confident that the Department of Biology in SUSTech will surely grow into a top tier globally-renowned research and teaching center!

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