Assistant Professor Department of Biology

Dr. Sicong He received his B. Eng. in Optical Engineering at Zhejiang University in 2012, and his Ph.D. in Electronic and Computer Engineering at Hong Kong University of Science and Technology in 2017. He worked as a postdoctoral fellow at Hong Kong University of Science and Technology in 2017-2020. He is currently a Tenure-Track Assistant Professor in School of Life Sciences at Southern University of Science and Technology. His research interests include development of novel optical imaging techniques and their biological applications. He has published over 20 papers in high-impact international scientific journals, including Elife, Light: Science & Applications, Science Advances, Developmental Cell, etc.

Personal Profile

Research

1. Adaptive-optics multiphoton fluorescence microscopy for high spatial-temporal resolution imaging

2. High resolution infrared laser-mediated gene induction microscopy for in vivo single-cell labeling and lineage tracing

3. Multimodal nonlinear optical microscopy integrating multiphoton fluorescence imaging, second/third harmonic generation, and stimulated Raman scattering


Publications Read More

  1. Congping Chen, Zhongya Qin, Sicong He, Shaojun Liu, Shun-Fat Lau, Wanjie Wu, Dan Zhu, Nancy Y. Ip and Jianan Y. Qu*, “High-resolution two-photon transcranial imaging of brain using direct wavefront sensing”, Photonics Research, Vol. 9, Issue 6, pp. 1144-1156 (2021)
  2. Zhongya Qin, Congping Chen, Sicong He, Ye Wang, Kam Fai Tam, Nancy Y. Ip* and Jianan Y. Qu*, “Adaptive optics two-photon endomicroscopy enables deep brain imaging at synaptic resolution over large volumes”, Science Advances, 30 Sep 2020: Vol. 6, no. 40, eabc6521 DOI: 10.1126/sciadv.abc6521
  3. Qixin Wei, Sicong He, Jianan Y. Quand Jiang Xia*, “Synthetic multienzyme complexes assembled on virus-like particles for cascade biosynthesis in cellulo”, Bioconjugate Chemistry, 2020, 31, 10, 2413–2420
  4. Sicong He, JinXu, Jianan  Qu* and Zilong Wen*, “Lightening the way of hematopoiesis: infrared laser-mediated lineage tracing with high spatial-temporal resolution”, Experimental hematology, V.85, P.3-7 (2020) 
  5. Miao Liu, Sicong He, Lixin Cheng, Jianan Qu and Jiang Xia*, “Phase-separated multienzyme biosynthesis”, Biomacromolecules, V.21, P.2391-2399 (2020)
  6. Zhongya Qin#, Sicong He#, Chao Yang, Jasmine Sum-Yee Yung, Congping Chen, Christopher Kai-Shun Leung, Kai Liu and Jianan Y. Qu*, “Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo“, Light: Science & Applications, (2020)9:79, https://doi.org/10.1038/s41377-020-0317-9
  7. Sicong He, Ye Tian, Shachuan Feng, Yi Wu, Xinwei Shen, Kani Chen, Yingzhu He, Qiqi Sun, Xuesong Li, Jin Xu*, Zilong Wen* andJianan Y. Qu*, In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy”, eLife 2020;9:e52024, DOI: 10.7554/eLife.52024
  8. Sicong He, Xiuqing Wei, Zhongya Qin, Congping Chen, Zhenguo Wu* and Jianan Y. Qu*, “In vivostudy of metabolic dynamics and heterogeneity in brown and beige fat by label-free multiphoton redox and fluorescence lifetime microscopy”, Journal of Biophotonics, e201960057 (2019) 
  9. Wei Kang, Tian Ma, Min Liu, Jiale Qu, Zhenjun Liu, Huawei Zhang, Bin Shi, Shuai Fu, Juncai Ma, Louis Tung Faat Lai, Sicong He, Jianan Qu, Shannon Wing-Ngor Au, Byung Ho Kang, Wilsn Chun Yu Lau, Zixin Deng, Jiang Xia*, Tiangang Liu*,”Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux.” Nature communications,  10, No. 1, 1-11 (2019)
  10. Xuesong Li, Yan Li, Meijuan Jiang, Wanjie Wu, Sicong He, Congping Chen, Zhongya Qin, Ben Zhong Tang, Ho Yi Mak*, Jianan Y Qu*, “Quantitative Imaging of Lipid Synthesis and Lipolysis Dynamics in Caenorhabditis elegans by Stimulated Raman Scattering Microscopy“,Analytical Chemistry, 91(3), 2279-2287 (2019) 
  11. ZhongyaQin, Qiqi Sun, Yue Lin, Sicong He, Xuesong Li, Congping Chen, Wanjie Wu, Yi Luo and Jianan Y. Qu*, “New fluorescent compounds produced by femtosecond laser surgery in biological tissues: the mechanisms”, Biomedical Optics Express, Vol. 9, No. 7, 3373-90 (2018) 
  12. Sicong He, Jiahao Chen, Yunyun Jiang, Yi Wu, Lu Zhu, Wan Jin, Changlong Zhao, Tao Yu, Tienan Wang,Shuting Wu, Jianan Qu, Zilong Wen, Wenqing Zhang and Jin Xu*, “Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells”, eLife, 7, e36131 (2018) 
  13. Sicong He, Yitai An, Xuesong Li, Xiuqing Wei, Qiqi Sun, Zhenguo Wu*, and Jianan Y. Qu*, “In vivometabolic imaging and monitoring of brown and beige fat.” Journal of Biophotonics, e201800019 (2018)
  14. Qiqi Sun, Zhongya Qin, Wanjie Wu, Yue Lin, Congping Chen, Sicong He, Xuesong Li, Zhenguo Wu, Yi Luo and Jianan Y. Qu*, “In vivoimaging-guided microsurgery based on femtosecond laser produced new fluorescent compounds in biological tissues”, Biomedical Optics Express, Vol. 9, No. 2, 581-90 (2018) 
  15. Ye Tian, Jin Xu, Shachuan Feng, Sicong He, Shizheng Zhao, Lu Zhu, Wan Jin, Yimei Dai, Lingfei Luo, Jianan Y Qu, Zilong Wen*, “The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells“, Journal of Experimental Medicine, jem-20170488 (2017)
  16. Sicong He, Wenqian Xue, Zhigang Duan, Qiqi Sun, Xuesong Li, Huiyan Gan, Jiandong Huang* and Jianan Y. Qu*, “Multimodal nonlinear optical microscopy reveals critical role of kinesin-1 in cartilage development”, Biomedical Optics Express, Vol. 8, 1771-1782 (2017)
  17. Tingzhong Li, Sicong He, Jianan Qu, Hao Wu, Shuizhu Wu, Zujin Zhao, Anjun Qin, Rongrong Hu*, Ben Zhong Tang*, “Thermoresponsive AIE polymers with fine-tuned response temperature”, Journal of Materials Chemistry C, V. 4, 2964-2970 (2016)
  18. Jin Xu, Lu Zhu, Sicong He, Yi Wu, Wan Jin, Tao Yu, Jianan Y. Qu* and Zilong Wen*, “Temporal-spatial resolution fate mapping reveals distinct origins for embryonic and adult microglia in zebrafish”, Developmental Cell, V. 34, 632-641 (2015)
  19. Xuesong Li, Wen Jiun Lam, Zhe Cao, Yan Hao, Qiqi Sun, Sicong He, Ho Yi Mak* and Jianan Y. Qu*, “Integrated femtosecond stimulated Raman scattering and two-photon fluorescence imaging of subcellular lipid and vesicular structures”, Journal of Biomedical Optics, V. 20, 110501 (2015)
  20. Sicong He, Cong Ye, Qiqi Sun, Christopher K.S. Leung* and Jianan Y. Qu*, “Label-free nonlinear optical imaging of mouse retina”, Biomedical Optics Express, Vol.6, No.1 (2015) 
  21. Yan Zeng, Bo Yan, Jin Xu, Qiqi Sun, Sicong He, Jun Jiang, Zilong Wen* and Jianan Y. Qu*, “In vivononlinear optical imaging of immune responses: tissue injury and infection”, Biophysical Journal, V.107, Issue of Nov. 18 (2014) 
  22. Yan Zeng, Bo Yan, Qiqi Sun, Sicong He, Jun Jiang, Zilong Wen* and Jianan Y. Qu*, “In vivo micro-vascular imaging and flow cytometry in zebrafish using two-photon excited endogenous fluorescence”, Biomedical Optics Express, V.5, 653-663 (2014)
  23. Qiqi Sun, Yanfeng Li, Sicong He, Chenghao Situ, Zhenguo Wu* and Jianan Y. Qu*, “Label-free multimodal nonlinear optical microscopy reveals fundamental insights of skeletal muscle development”, Biomedical Optics Express, V.5, 158-166 (2014)

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Contact Address

Room 416, Building B, 1088 Xueyuan Avenue, Nanshan District, Shenzhen 518055, P.R. China

Office Phone

0755-88015096

Email

hesc@sustech.edu.cn

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