Associate Professor(Research Scientist) Department of Biology

We use structural biology, biochemical and biophysical approaches to study the structure and function of disease-related cholesterol and lipid metabolism regulatory proteins

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Protein Engineering

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(*,co-first author; #, co-corresponding author).

◆ Qian H*,Cao P*, Hu M, Gao S, Yan N#, Gong X#. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nature Communications. 2019 May 24; 10(1): 2320.

◆ Gong X*, Qian H*, Cao P*, Zhao X, Zhou Q, Lei J, Yan N#. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018 Aug 10;361(6402).

◆ Qian H*, Zhao X, Cao P, Lei J, Yan N#, and Gong X*, #. Structure of the human lipid exporter ABCA1. Cell. 2017 Jun 15; 169(7), 1228–1239.

◆ Gong X*, Qian H*, Shao W*, Li J, Wu J, Liu J, Li W, Wang H, Espenshade P#, Yan N#. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Research. 2016 Nov;26(11):1197-1211.

◆ Gong X*, Qian H*, Zhou X*, Wu J*, Wan T*, Cao P, Huang W, Zhao X, Wang X, Wang P, Shi Y, Gao GF, Zhou Q#, Yan N#. Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell. 2016 Jun 2;165(6):1467-78.

◆ Gong X*, Li J*, Shao W*, Wu J, Qian H, Ren R, Espenshade P#, Yan N#. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Research. 2015 Apr;25(4):401-11.

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