Associate Professor |School of Life Sciences, Department of Biology

We use structural biology, biochemical and biophysical approaches to study the structure and mechanism of key membrane proteins in lipid metabolism or some other physiologically important membrane proteins.

Personal Profile


◆ Structural insights into the cellular lipid metabolism

◆ Molecular mechanisms of membrane proteins


◆ Protein Engineering

◆ Bioseparations

Publications Read More

Selected Publication  (*, co-first authors; #, co-corresponding authors)

◆ Li W*, Wang L*, Wierbowski BM*, Lu M, Dong F, Liu W, Li S, Wang P, Salic A#Gong X#Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nature Communications. 2021 Nov 29;12(1):6966.

◆ Xie T*, Zhang Z*, Fang Q, Du B, Gong X#Structural basis of substrate recognition and translocation by human ABCA4.  Nature Communications2021 Jun 22;12(1):3853.

◆ Li S*, Xie T*, Liu P*, Wang L, Gong X#. Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex. Nature Structural & Molecular Biology2021 Mar; 28(3)249–257. (Cover Story)

◆ Ma L, Guan Z, Wang Q, Yan X, Wang J, Wang J, Cao J, Zhang D, Gong X#Yin P#. Structural insights into the photoactivation of Arabidopsis CRY2. Nature Plants2020. Nov 16; 6(12), 1432-1438.

◆ Qian H*,Cao P*, Hu M, Gao S, Yan N#Gong X#. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nature Communications2019 May 24; 10(1): 2320.


Prior to 2019

◆ Qian H*, Zhao X, Cao P, Lei J, Yan N#, and Gong X*, #. Structure of the human lipid exporter ABCA1. Cell. 2017 Jun 15; 169(7), 1228–1239.

◆ Gong X*, Qian H*, Cao P*, Zhao X, Zhou Q, Lei J, Yan N#. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018 Aug 10;361(6402).

 Gong X*, Qian H*, Zhou X*, Wu J*, Wan T*, Cao P, Huang W, Zhao X, Wang X, Wang P, Shi Y, Gao GF, Zhou Q#, Yan N#. Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell2016 Jun 2;165(6):1467-78.

 Gong X*, Qian H*, Shao W*, Li J, Wu J, Liu J, Li W, Wang H, Espenshade P#, Yan N#. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Research2016 Nov;26(11):1197-1211.

 Gong X*, Li J*, Shao W*, Wu J, Qian H, Ren R, Espenshade P#, Yan N#. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Research2015 Apr;25(4):401-11.

News More

  • Revealing proteolytic activation of human Dispatched1 for Hedgehog morphogen release

  • Congratulations to ZHANG Zike & LIU Peng on winning the 2021 National Scholarship!

  • Revealing substrate recognition and translocation mechanism of human ABCA4 in retinoid cycle


Lab members Read More

Join us

Postdoctoral Research Associate

We are seeking highly motivated Postdoc Research Associates to join Dr. GONG Xin’s lab at SUSTech. Successful candidates will lead research projects focusing on structural mechanisms of membrane proteins.  We use cryo-EM, biophysical, and biochemical approaches to study the structure and function of membrane proteins. The lab has fully access to the cryo-EM facility in SUSTech, which houses six 300kV Titan Krios electron microscopes, all of them equipped with K2 or K3 detectors.

This position is always open.

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