Associate Professor(Research Scientist) Department of Biology

We use structural biology, biochemical and biophysical approaches to study the structure and function of disease-related cholesterol and lipid metabolism regulatory proteins

Personal Profile


1. Regulation of Cholesterol Homeostasis

2. Intracellular Cholesterol Trafficking

3. Reverse Cholesterol Transport

4. Hedgehog Signaling

5. Phospholipid and Sphingolipid Metabolism


◆Protein Engineering

◆Bioseparations laboratory

Publications Read More

(*,co-first author; #, co-corresponding author).

◆ Xie T*, Zhang Z*, Du B, Fang Q, Gong X#. Structural basis of substrate recognition and translocation by human ABCA4. BioRxiv. 2021 Feb 27.

◆ Li S*, Xie T*, Liu P*, Wang L, Gong X#. Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex. Nature Structural & Molecular Biology. 2021. Mar; 28(3), 249–257. (Highlight in News & Views, Cover Story)

◆ Ma L, Guan Z, Wang Q, Yan X, Wang J, Wang J, Cao J, Zhang D,  Gong X#,Yin P#. Structural insights into the photoactivation of Arabidopsis CRY2. Nature Plants. 2020. Nov 16; 6(12), 1432-1438.

◆ Qian H*,Cao P*, Hu M, Gao S, Yan N#, Gong X#. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nature Communications. 2019 May 24; 10(1): 2320.

Gong X*, Qian H*, Cao P*, Zhao X, Zhou Q, Lei J, Yan N#. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018 Aug 10;361(6402).

◆ Qian H*, Zhao X, Cao P, Lei J, Yan N#, and Gong X*, #. Structure of the human lipid exporter ABCA1. Cell. 2017 Jun 15; 169(7), 1228–1239.

Gong X*, Qian H*, Shao W*, Li J, Wu J, Liu J, Li W, Wang H, Espenshade P#, Yan N#. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Research. 2016 Nov;26(11):1197-1211.

Gong X*, Qian H*, Zhou X*, Wu J*, Wan T*, Cao P, Huang W, Zhao X, Wang X, Wang P, Shi Y, Gao GF, Zhou Q#, Yan N#. Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell. 2016 Jun 2;165(6):1467-78.

Gong X*, Li J*, Shao W*, Wu J, Qian H, Ren R, Espenshade P#, Yan N#. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Research. 2015 Apr;25(4):401-11.

News More

  • GONG Lab‘s Happy Hour!

  • SUSTech uncovers the assembly and substrate selectivity of human SPT-ORMDL3 complex in sphingolipid biosynthesis


Lab members Read More

Join us

Postdoctoral Research Associate

We are seeking highly motivated Postdoc Research Associates to join Dr. GONG Xin’s lab at SUStech. Successful candidates will lead research projects focusing on structural mechanisms of membrane proteins.  We use cryo-EM, biophysical, and biochemical approaches to study the structure and function of membrane proteins. The lab has fully access to the cryo-EM facility in SUStech, which houses six 300kV Titan Krios electron microscopes, all of them equipped with K2 or K3 detectors.

This position is always open.

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