杜长征

副教授 |医学院

专业从事胃肠道恶性肿瘤的外科治疗多年,擅长消化道肿瘤的手术与多学科综合治疗,临床经验丰富。在国内首创直肠癌的非手术疗法,研究成果在2017年ASCO会议展出。擅长运用基础研究解决临床问题,研究方向为肿瘤分子生物学与表观遗传学,尤其注重研究成果的临床转化。已在国际知名期刊,如Cell Reports, Cancer Letters等杂志发表论文二十余篇。主持基金数项,包括国家自然科学基金面上项目和广东省教育厅生物医药与健康重点领域专项。担任数个学术任职,包括广东省药学会第一届肿瘤全程管理专家委员会委员,深圳市医师协会智能与数字外科专业委员会常务理事,深圳市医师协会胃肠外科医师分会第二届理事会常务理事等。

个人简介

研究领域

肿瘤学; 外科学; 表观遗传学; 分子生物学


教学

转化医学

面向研究生及本科三年级以上(含)


学术成果 查看更多

主要SCI论文:

  1. Du C, Li SW, Singh SX, Roso K, Sun MA, Pirozzi CJ, Yang R, Li JL, He Y. Epigenetic Regulation of Fanconi Anemia Genes Implicates PRMT5 Blockage as a Strategy for Tumor Chemosensitization. Mol Cancer Res. 2021 Dec;19(12):2046-2056

  2. Han Z, Li M, Chen J, Ji D, Zhan T, Peng Y, Xue W, Li Y, Cai Y, Sun Y, Wu Q, Du C, Gu J. Surgery may not benefit patients with locally advanced rectal cancer who achieved clinical complete response following neoadjuvant chemoradiotherapy. Asian J Surg. 2021 Apr 19; S1015-9584(21)00176-7

  3. Du C, Peng Y, He Y, Chen G, Chen H. Low levels of BRCA1 protein expression predict a worse prognosis in stage I-II colon cancer. Int J Biol Markers. 2021 Mar; 36(1):47-53.
  4. Dan C, Pei H, Zhang B, et al. Fanconi anemia pathway and its relationship with cancer[J]. Genome Instability & Disease, 2021: 1-9.
  5. Du C, Hansen LJ, Singh SX, Wang F, Sun R, Moure CJ, Roso K, Greer PK, Yan H, He Y. A PRMT5-RNF168-SMURF2 axis controls H2AX proteostasis. Cell rep. 2019, 28: 3199-3211.
  6. Du C, Huang D, Peng Y, Yao Y, Zhao Y, Yang Y, Wang H, Cao L, Zhu WG, Gu J. 5-Fluorouracil targets histone acetyltransferases p300/CBP in the treatment of colorectal cancer. Cancer Lett. 2017 Aug 1; 400:183-193.
  7. Du C, Xue W, Dou F, Peng Y, Yao Y, Zhao J, Gu J. Use of a combination of CEA and tumor budding to identify high-risk patients with stage II colon cancer. Int J Biol Markers. 2017 Jul 24; 32(3):e267-e273.
  8. Du C, Yao Y, Xue W, Zhu WG, Peng Y, Gu J. The expression of chemokine receptors CXCR3 and CXCR4 in predicting postoperative tumour progression in stages I-II colon cancer: a retrospective study. BMJ Open. 2014; 4(8):e005012.
  9. Du C, Zhao J, Xue W, Dou F, Gu J. Prognostic value of microsatellite instability in sporadic locally advanced rectal cancer following neoadjuvant radiotherapy. Histopathology. 2013 Apr; 62(5):723-30.
  10. Du C, Xue W, Li J, Cai Y, Gu J. Morphology and prognostic value of tumor budding in rectal cancer after neoadjuvant radiotherapy. Hum Pathol. 2012 Jul; 43(7):1061-7.
  11. Du CZ, Chen YC, Cai Y, Xue WC, Gu J. Oncologic outcomes of primary and post-irradiated early stage rectal cancer: a retrospective cohort study. World J Gastroenterol. 2011 Jul 21; 17(27):3229-34.
  12. Du CZ, Li J, Cai Y, Sun YS, Xue WC, Gu J. Effect of multidisciplinary team treatment on outcomes of patients with gastrointestinal malignancy. World J Gastroenterol. 2011 Apr 21; 17(15):2013-8.
  13. Du CZ, Xue WC, Cai Y, Li M, Gu J. Lymphovascular invasion in rectal cancer following neoadjuvant radiotherapy: a retrospective cohort study. World J Gastroenterol. 2009 Aug 14; 15(30):3793-8.
  14. Du CZ, Gu J. Adoptability and limitation of cancer treatment guidelines: a Chinese oncologist’s perspective. Chin Med J (Engl). 2012 Mar; 125(5):725-7.
  15. Cao LL, Du C*, Liu H, Pei L, Qin L, Jia M, Wang H. Lysine-specific demethylase 2A expression is associated with cell growth and cyclin D1 expression in colorectal adenocarcinoma. Int J Biol Markers. 2018 Apr 1:1724600818764069.(*co-first author)
  16. Hu D, Du C*, Xue W, Dou F, Yao Y, Gu J. The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ-specific for distant metastasis in colorectal cancer: a comparative study. Histopathology. 2013 Aug; 63(2):167-73. (*co-first author)
  17. Zhao J, Du CZ*, Sun YS, Gu J. Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment. World J Gastroenterol. 2012 Dec 21; 18(47):7015-20. (*co-first author)
  18. Huang D, Du C, Ji D, Xi J, Gu J. Overexpression of LAMC2 predicts poor prognosis in colorectal cancer patients and promotes cancer cell proliferation, migration, and invasion. Tumour Biol. 2017 Jun; 39(6):1010428317705849.
  19. Li Z, Yang L, Du C, Fang X, Wang N, Gu J. Characteristics and comparison of colorectal cancer incidence in Beijing with other regions in the world. Oncotarget. 2017 Apr 11; 8(15):24593-24603.
  20. Tang M, Lu X, Zhang C, Du C, Cao L, Hou T, Li Z, Tu B, Cao Z, Li Y, Chen Y, Jiang L, Wang H, Wang L, Liu B, Xu X, Luo J, Wang J, Gu J, Wang H, Zhu WG. Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer. Theranostics. 2017; 7(5):1346-1359.
  21. Pan HD, Wang L, Peng YF, Li M, Yao YF, Zhao J, Zhan TC, Du CZ, Gu J. Subcutaneous vacuum drains reduce surgical site infection after primary closure of defunctioning ileostomy. Int J Colorectal Dis. 2015 Jul; 30(7):977-82.

    Zhang P, Ji DB, Han HB, Shi YF, Du CZ, Gu J. Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer. World J Gastroenterol. 2014 Sep 14; 20(34):12241-8.

  22. Yao YF, Du CZ, Chen N, Chen P, Gu J. Expression of HER-2 in rectal cancers treated with preoperative radiotherapy: a potential biomarker predictive of metastasis. Dis Colon Rectum. 2014 May; 57(5):602-7.

    Zhan T, Gu J, Li M, Du C. Intermediate-fraction neoadjuvant radiotherapy for rectal cancer. Dis Colon Rectum. 2013 Apr; 56(4):422-32.

  23. Peng Y, Wang L, Du C, Gu J. Expression of vascular endothelial growth factor can predict distant metastasis and disease-free survival for clinical stage III rectal cancer following 30-Gy/10-f preoperative radiotherapy. Int J Colorectal Dis. 2012 Dec; 27(12):1555-60.
  24. Cai Y, Du C, Zhu X, Xu B, Gu J. Neoadjuvant therapy for advanced rectal carcinoma in China: Whether radiochemotherapy is superior to radiotherapy? Chin J Cancer Res. 2009 Jun; 21(4):295-262.
  25. Wang Q, Chen ZG, Du CZ, Wang HW, Yan L, Gu J. Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer. Histopathology. 2009 Sep; 55(3):284-93.

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