Professor |School of Life Sciences, Department of Biology

Dr. Tao Dong is a full professor in the School of Life Sciences at SUSTech. He obtained his BSc from Shandong University and PhD from McMaster University. He then moved to Boston for his postdoctoral training with John Mekalanos at Harvard Medical School, during which he received the prestigious Banting fellowship. He became an assistant professor in 2013 at the University of Calgary and was promoted to tenured associate and later full professor before he joined SUSTech.

(https://orcid.org/0000-0003-3557-1850)

Personal Profile

Research

Dr. Dong’s research is focused on understanding the molecular adaptation mechanisms that enable bacteria to survive in diverse natural and host environments, finding novel antimicrobials, and understanding how protein secretion systems function during host-pathogen interactions.


Publications Read More

(1)  Hersch, S. J.; Lam, L.; Dong, T. G. Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase. mBio 2021, 12 (4), 2021.05.11.443660. https://doi.org/10.1128/mBio.01115-21.

(2) Manera, K.; Caro, F.; Li, H.; Pei, T.-T.; Hersch, S. J.; Mekalanos, J. J.; Dong, T. G. Sensing of Intracellular Hcp Levels Controls T6SS Expression in Vibrio Cholerae. Proc. Natl. Acad. Sci. 2021, 118 (25), e2104813118. https://doi.org/10.1073/pnas.2104813118.

(3) Hersch, S. J.; Watanabe, N.; Stietz, M. S.; Manera, K.; Kamal, F.; Burkinshaw, B.; Lam, L.; Pun, A.; Li, M.; Savchenko, A.; Dong, T. G. Envelope Stress Responses Defend against Type Six Secretion System Attacks Independently of Immunity Proteins. Nat. Microbiol. 2020, 5 (5), 706–714. https://doi.org/10.1038/s41564-020-0672-6.

(4) Pei, T.-T.; Li, H.; Liang, X.; Wang, Z.-H.; Liu, G.; Wu, L.-L.; Kim, H.; Xie, Z.; Yu, M.; Lin, S.; Xu, P.; Dong, T. G. Intramolecular Chaperone-Mediated Secretion of an Rhs Effector Toxin by a Type VI Secretion System. Nat. Commun. 2020, 11 (1), 1865. https://doi.org/10.1038/s41467-020-15774-z.

(5) Stietz, M. S.; Liang, X.; Li, H.; Zhang, X.; Dong, T. G. TssA–TssM–TagA Interaction Modulates Type VI Secretion System Sheath-Tube Assembly in Vibrio Cholerae. Nat. Commun. 2020, 11 (1), 5065. https://doi.org/10.1038/s41467-020-18807-9.

(6) Liang, X.; Kamal, F.; Pei, T.-T.; Xu, P.; Mekalanos, J. J.; Dong, T. G. An Onboard Checking Mechanism Ensures Effector Delivery of the Type VI Secretion System in Vibrio Cholerae. Proc. Natl. Acad. Sci. 2019, 116 (46), 23292–23298. https://doi.org/10.1073/pnas.1914202116.

(7) Burkinshaw, B. J.; Liang, X.; Wong, M.; Le, A. N. H.; Lam, L.; Dong, T. G. A Type VI Secretion System Effector Delivery Mechanism Dependent on PAAR and a Chaperone–Co-Chaperone Complex. Nat. Microbiol. 2018, 3 (5), 632–640. https://doi.org/10.1038/s41564-018-0144-4.

(8) Liang, X.; Moore, R.; Wilton, M.; Wong, M. J. Q.; Lam, L.; Dong, T. G. Identification of Divergent Type VI Secretion Effectors Using a Conserved Chaperone Domain. Proc. Natl. Acad. Sci. 2015, 112 (29), 9106–9111. https://doi.org/10.1073/pnas.1505317112.

Lab members Read More

Join us

Multiple positions are currently open for international postdoctoral fellows and graduate students who are interested in host-microbe interactions. Internationally competitive fellowships and scholarships will be provided to successful applicants. For all enquiries, please email Professor Dong directly with your CV, representative publications, and transcripts (for students). 

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Contact Us

Contact Address

School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

Office Phone

(86)-(0755)-88018724

Email

dongt@sustech.edu.cn

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