助理教授 |医学院

陈浩,南方科技大学医学院博士生导师,分别于武汉大学生物学基地班和复旦大学生物医学研究院获得本科和博士学位,2015年2月至2019年12月在哈佛医学院进行博士后训练,2020年加入南方科技大学。研究方向为肿瘤及代谢类疾病(糖尿病、肥胖等)发生的表观遗传学机制,本课题组使用生物化学技术,结合多组学方法,鉴定和研究新型RNA/DNA表观遗传学修饰酶的分布模式和生物学功能;同时,致力于开发新的表观研究技术,探索表观遗传学修饰失调引起各类疾病发生的分子机制,寻找治疗癌症及各种代谢类疾病的表观遗传学靶点。

近年来一直从事解析新型RNA/DNA表观遗传学修饰调节异常促进疾病发生的分子机制。近年来取得多项成果:1)对RNA修饰进行系统性研究,发现多种新型RNA修饰酶,其中包括METTL4 (Cell Research, 2020; Cell Discovery, 2020);METTL5 (EMBO Reports, 2020; bioRxiv, 2020); METTL15 (JBC, 2020); ZCCH4 (NCB,2019 ), PCIF1(Mol Cell,2019), METTL3/14 (Nature, 2017); 2)阐明糖尿病导致的糖代谢异常促进肿瘤发生的分子机制(Nature,2018; Cell Research, 2019);3)通过分析影响表观遗传核心蛋白稳定性的调节因子,揭示外界刺激如何信号传导通路调控表观遗传学建立及维持的新机制(PNAS,2012;MCB,2013);至今,已发表研究论文共计18篇,其中,以一作(含共一)或/和共同通讯,在Nature,Cell Research,EMBO Reports等杂志发表论文9篇,多篇文章被highlight于Nature Reviews等杂志或标记为F1000 recommended。

个人简介

研究领域

1. 肿瘤及代谢类疾病(糖尿病及肥胖等)发生的表观遗传学机制;

2. 新型表观遗传学修饰的鉴定与功能研究。


教学

医学表观遗传学

Advanced biological sciences


学术成果 查看更多

近三年代表性论文:

1.Xing,M.#, Liu, Q.#, Mao, C., Zeng, H., Zhang, X., Zhao, S., Chen, L., Liu, M., Shen, B., Guo, X.,Ma,H.*, Chen, H.*,and Zhang, J.*. The 18S rRNA m6A methyltransferase regulates mouse embryonic stem cell differentiation. EMBO Reports. ( *co-corresponding author)

2.Chen, H.#, Gu, L.#, Orellana, E., Wang, Y., Guo, J., Liu, Q., Gregory, R., Xing, Y., Shi, Y. (2020). METTL4 is an m6Am methyltransferase that regulates RNA splicing. Cell Research. doi:10.1038 /s41422-019-0270-4 (#co-first author, F1000 recommended)

3.Wu, D.#, Hu, D.#, Chen, H.#, Shi, G.#, Fetahu, I. S., Wu, F., . . . Shi, Y. G. (2018). Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature. 559(7715), 637-641. (#co-first author)

4.Chen, H., Yu, D., Fang, R., Rabidou, K., Wu, D., Hu, D., . . Shi, Y. G. (2019). TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer. Cell Research. 29, 248–250.

5.Chen, H., Shi, Z., Guo, J., Chang, K., Chen, Q., Yao, C., Haigis,M., Shi, Y. (2020). The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for proper mitochondrial function. Journal of Biological Chemistry. jbc. RA119. 012127

6.Gu, L.#,Wang, L.#, Chen, H.#, Hong, J.#, Shen, Z., Dhall, A., Lao, T., . . . Wu, H., Shi, Y. (2020). CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila. Cell DIscovery (#co-first author)

7.Chen, H.#, Liu, Q.#, Yu, D., Natchiar, K., Zhou, C., Hsu, C.-h., Hsu, P.-H., Zhang, X., Klaholz, B., Gregory, R. and Shi, Y. (2020) METTL5, an 18S rRNA-specific m6A methyltransferase, modulates expression of stress response genes. bioRxiv. doi: https://doi.org/10.1101/2020.04.27.064162 (#co-first author)

8.Sendinc, E., Valle-Garcia, D., Dhall, A., Chen, H., Henriques, T., Navarrete-Perea, J., Sheng, W., Gygi, S., Adelman, K., Shi, Y.(2019). PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression. Molecular Cell.

9.Ma, H., Wang, X., Cai, J., Dai, Q., Natchiar, S. K., Lv, R., . . Chen, H., . . He,C. (2019). N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nature Chemical Biology. 15(1), 88.

10.Lee, Y., Chen, M., Lee, J., Zhang, J., Lin, S., Fu, T., Chen, H., Ishikawa, T., Chiang, S., Katon, J., …. Wei W., Pandolfi P.(2019). Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 364,6441

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