研究助理教授 理学院

陈根强,理学博士,硕士生导师。工作学习经历:2018年7月至今,研究助理教授,南方科技大学前沿与交叉科学研究院;2015年12月-2018年6月,南方科技大学,化学系,校长卓越博士后,合作导师:张绪穆;2010年9月-2015年6月,中国科学院上海有机化学研究所,有机化学博士,导师:施敏研究员;2006年9月-2010年6月,郑州大学,化学系,学士,导师:陶京朝教授。

个人简介

研究领域

主要研究领域包括:有机合成,手性配体,不对称催化,不对称氢化等。主要从事新型手性配体的设计合成,以及这些配体在不对称催化领域的应用。


学术成果 查看更多

目前在国际知名期刊JACS,Angew,Chem. Sci.,Chem. Commun.等国际知名期刊上发表十余篇学术论文。先后主持了深圳市自由探索项目(深圳市自由探索项目,项目编号:JCYJ20170817105056467,30万)和国自然青年基金项目(国家自然科学基金青年项目,项目编号:21901107,25万)。他开发的新型手性氧杂螺环配体在许多挑战的不对称催化反应中得到了应用,这些应用包括Bringmann内酯的动态动力学拆分,不饱和羧酸的不对称氢化以及重大药物LCZ696的高效合成等。

1. Chen, G.-Q.; Tang, X.-Y.; Shi, M., HOTf mediated cascade reactions of 1-arenoylcyclopropanecarboxylic acids with arenes. Chem. Commun. 2012, 48, 2340-2342.

2. Chen, G.-Q.; Shi, M., Rhodium-catalyzed tandem Pauson-Khand type reactions of 1,4-enynes tethered by a cyclopropyl group. Chem. Commun. 2013, 49, 698-700.

3. Zhang, X.-N.; Chen, G.-Q.; Dong, X.; Wei, Y.; Shi, M., Phosphine-Catalyzed Asymmetric [4+2| Annulation of Vinyl Ketones with Oxindole-Derived α,β-Unsaturated Imines: Enantioselective Syntheses of 2′,3′-Dihydro-1’H-spiro[indoline-3,4′-pyridin -2-ones. Adv. Synth. Catal. 2013, 355, 3351-3357.

4. Chen, G.-Q.; Tang, X.-Y.; Shi, M., Rhodium-catalyzed carbonylative skeleton rearrangement of 1,4-enynes tethered by a cyclopropane group. Synlett 2014, 25, 2311-2315.

5. Chen, G.-Q.; Tang, X.-Y.; Shi, M., Silver(I)-mediated dual cleavage of C-C and C-O bonds in the reaction of diarylmethylenecyclopropanes with tetrahydrofuran. Synthesis of 4-(3-halobut-3-enyloxy)butyl 2,2,2-trifluoroacetate derivatives. Eur. J. Org. Chem. 2014, 2014, 194-197.

6. Chen, G.-Q.; Zhang, X.-N.; Wei, Y.; Tang, X.-Y.; Shi, M., Catalyst-dependent divergent synthesis of pyrroles from 3-alkynyl imine derivatives: A noncarbonylative and carbonylative approach. Angew. Chem., Int. Ed. 2014, 53, 8492-8497.

7. Zhang, X.-N.; Chen, G.-Q.; Tang, X.-Y.; Wei, Y.; Shi, M., Phosphine-Catalyzed Annulations of 4,4-Dicyano-2-methylene-3-butenoates with Maleimides and Maleic Anhydride. Angew. Chem., Int. Ed. 2014, 53, 10768-10773.

8. Pan, D.; Chen, G.-Q.; Tang, X.-Y.; Shi, M., Palladium-catalyzed intramolecular rearrangement of vinylidenecyclopropanes through C-C bond activation. Org. Chem. Front. 2015, 2, 792-796.

9. Chen, G.-Q.; Fang, W.; Wei, Y.; Tang, X.-Y.; Shi, M., Gold(I)-catalyzed dehydrogenative cycloisomerization of 1,5-enynes. Chem. Commun. 2016, 52, 10799-10802.

10. Chen, G.-Q.; Fang, W.; Wei, Y.; Tang, X.-Y.; Shi, M., Divergent reaction pathways in gold-catalyzed cycloisomerization of 1,5-enynes containing a cyclopropane ring: dramatic ortho substituent and temperature effects. Chem. Sci. 2016, 7, 4318-4328.

11. Chen, G.-Q.; Lin, B.-J.; Huang, J.-M.; Zhao, L.-Y.; Chen, Q.-S.; Jia, S.-P.; Yin, Q.; Zhang, X., Design and Synthesis of Chiral oxa-Spirocyclic Ligands for Ir-Catalyzed Direct Asymmetric Reduction of Bringmann’s Lactones with Molecular H2. J. Am. Chem. Soc. 2018, 140, 8064-8068.

12. Hu, L. a.; Zhang, Y.; Chen, G.-Q.; Lin, B.-J.; Zhang, Q.-W.; Yin, Q.; Zhang, X., CuH-Catalyzed Atropoenantioselective Reduction of Bringmann’s Lactones via Dynamic Kinetic Resolution. Org. Lett. 2019, 21, 5575-5580.

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