◆Discovery and Analysis of Biosynthetic Pathways of Plant Natural Products

◆Development and Utilization of Multi-Omics Technologies

◆Small Molecule-Mediated Plant-Microbe Interactions

1] Luo, F.#; Zhou, Q.#; Chen, F.; Liu, X.; Chiu, T.-Y.; Zhu, G.-Y.; Huang, A.C.* Divergent multifunctional P450s-empowered biosynthesis of bioactive tripterifordin and cryptic atiserenoids in Aconitum implies convergent evolution. Nature Communications, 16, 5857 (2025).

[2]  Xie, J.#; Tian, J. #; Khan, S.; Chen, F.; Yu, J.; Hao, Y.; Xiong, H.-M.; Zhang, F.; Zhou, Q.; Zhu, G.-Y.; Huang, A.C.* Glyceollin biosynthesis in a plant chassis engineered for isoflavone production. Nature Chemical Biology, 2025, 21(10):1497-1508.

[3] Zhou, Q.; Sun, P.; Xiong, H.; Xie, J.; Zhu, G.; Tantillo, Dean J.; Huang, AC.* (2023) Insight into neo-functionalization of 2,3-oxidosqualene cyclases in B,C-ring-opened triterpene biosynthesis in quinoa. New Phytologist, 2024, 241(2): 764-778.  

[4] Hong, Y.#; Yu, Z.#; Zhou, Q.; Chen C.; Hao, Y.; Wang, Z.; Zhu, J.; Guo, H.; Huang, A.C.* (2024) NAD⁺ deficiency primes defense metabolism via ¹O₂-escalated jasmonate biosynthesis in plants. Nature Communications, 15(1):6652.

[5] Hong, Y.#, Zhou, Q.#; Hao, Y.; Huang, AC.* (2021) Crafting plant root metabolome for improved microbe-assisted stress resilience. New Phytologist, 2022, 234(6): 1945-1950.

[6] Zhou, Q.#; Fu, H.#; Yang, D.; Ye, C.; Zhu, S.; Lin, J.; Ye, W.; Ji, G.; Ye, X.; Wu, X.*, Li, QQ.* (2018) Differential alternative polyadenylation contributes to the developmental divergence between two rice subspecies Japonica and Indica.The Plant Journal, 2019, 98(2):260-276.

[7] Zhou, Q.; Guo, J.; He, C.; Shen, C.; Huang, Y.; Chen, J.; Guo, J.; Yuan, J.; Yang, Z.* (2016) Comparative transcriptome analysis between low-and high-cadmium-accumulating genotypes of pakchoi (Brassica chinensis L.) in response to cadmium stress. Environmental science & technology, 50(12): 6485-6494

#co-first author; * Corresponding author.