Chair Professor |School of Life Sciences, Department of Neuroscience
Xiaochen Wang，Chair Professor，School of Life Sciences
Professor Xiaochen Wang obtained her Ph.D. degree at Peking University in 1999 and completed postdoc training at University of Colorado, Boulder, USA in 2006. Then she established her own laboratory at National Institute of Biological Sciences (NIBS, Beijing) in 2006 and was promoted to associate investigator in 2011. From 2016 to 2023, Dr. Wang has been an investigator in Institute of Biophysics, Chinese Academy of Science. In 2023, she joined the School of Life Sciences at SUSTech as Chair professor. Prof. Wang was selected as an international early career scientist of Howard Hughes Medical Institute (HHMI) in 2012. She received National Young Women Scientist Award and Distinguished Young Scholar Fellowship in 2013.
Personal Profile
Research
Our research focuses on lysosome-mediated cellular degradation processes. Employing C. elegans as a model system and taking a combinatory approach of genetics, cell biology, and biochemistry, we investigate how lysosome homeostasis is regulated and contributes to animal physiology and pathology, and how apoptotic cells are cleared via lysosome-dependent pathways.
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- Zhang Q, Li Y, Jian Y, Li M, Wang X* (2023). Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation. J Cell Biol. 222(6):e202210063.
- Sun Y, Li M, Zhao D, Li X, Yang C, Wang X*(2020). Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C.elegans. eLife 9:e55745
- Miao R, Li M, Zhang Q, Yang C, Wang X*(2020). An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Dev Cell. 52:21-37
- Liu Y, Zou W, Yang P, Wang L, Ma Y, Zhang H, Wang X*(2018). Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotidehomeostasis during C. elegans development. eLlife. 7: e36588.
- Yin J#, Huang Y#, Guo P, Hu S, Yoshina S, Xuan N, Gan Q, Mitani S, Yang C, Wang X*(2017). GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans. J Cell Biol. 216(6):1775-1794.
- Li Y, Chen B, Zou W, Wang X, Wu Y, Zhao D, Sun Y, Liu Y, Chen L, Miao L, Yang C, Wang X* (2016). The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity. J Cell Biol, 215 (2):167-185.
- Cheng S, Wang K, Zou W, Miao R, Huang Y, Wang H, Wang X* (2015). PtdIns(4,5)P2 and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance. J Cell Biol, 210(3):485-502.
- Zhang Y, Wang H, Kage-Nakadai E, Mitani S,Wang X* (2012). C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment. Current Biol, 22(14):1276-1284.
- Liu B#, Du H#, Rutkowski R, Gartner A, Wang X*(2012). LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science, 337(6092):351-354.
- Guo P, Hu T, Zhang J, Jiang S, Wang X*(2010). Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation. Proc Natl Acad Sci U S A, 107(42):18016-18021.
- Wang X*,Li W, Zhao D, Liu B, Shi Y, Chen B, Yang H, Guo P, Geng X, Shang Z, Peden E, Kage-Nakadai E, Mitani S, Xue D* (2010). Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nat Cell Biol, 12(7):655-664.
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Contact Us
Contact Address
Room 316, Research Building 2, 1088 Xueyuan Avenue, Nanshan District, Shenzhen, P.R. China
Office Phone
wangxc7@sustech.edu.cn