梁征宇

科研项目

助理教授 |生命科学学院, 系统生物学系

梁征宇2012年本科毕业于华中科技大学生物信息技术专业，2018年博士毕业于清华大学生物学专业（导师张奇伟教授），2018-2023年于加州大学圣地亚哥分校细胞与分子医学系从事博士后研究（导师付向东教授），于2023年4月全职回国加入南方科技大学生命科学学院，担任助理教授，博士生导师，独立课题组长（PI）。

梁征宇博士致力于功能基因组学的研究，运用生物信息学及细胞和分子生物学方法，研究基因组三维空间结构、基因转录调控、RNA代谢及功能等系列科学问题，特别是研究肿瘤中染色体外DNA（extrachromosomal DNA）的结构与功能，以第一作者（含共同）身份在Cell、Circulation、Nature Communication、Cell Reports等国际期刊上发表研究论文多篇。

个人简介

研究领域

◆ 三维基因组的检测技术开发和功能研究

◆ 转录调控机制研究

◆ RNA代谢及参与基因组功能研究

◆ 肿瘤中染色体外DNA的结构与功能研究

学术成果查看更多

Xiao, R.*, Chen, J.-Y.*, Liang, Z.*, Luo, D., Chen, G., Lu, Z.J., Chen, Y., Zhou, B., Li, H., and Du, X. (2019). Pervasive chromatin-RNA binding protein interactions enable RNA-based regulation of transcription. Cell 178, 107-121. e118.
Liang, Z., Li, G., Wang, Z., Djekidel, M.N., Li, Y., Qian, M.-P., Zhang, M.Q., and Chen, Y. (2017). BL-Hi-C is an efficient and sensitive approach for capturing structural and regulatory chromatin interactions. Nature communications 8, 1622.
Liang, Z., and Fu, X.-D. (2021). 3D genome encoded by LINE and SINE repeats. Cell Research 31, 603-604.
Wu, T.*, Liang, Z.*, Zhang, Z., Liu, C., Zhang, L., Gu, Y., Peterson, K.L., Evans, S.M., Fu, X.-D., and Chen, J. (2022). PRDM16 is a compact myocardium-enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle. Circulation 145, 586-602.
Song, Y.*, Liang, Z.*, Zhang, J.*, Hu, G.*, Wang, J., Li, Y., Guo, R., Dong, X., Babarinde, I.A., and Ping, W. (2022). CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming. Cell Reports 39, 110626.
Qian, H., Kang, X., Hu, J., Zhang, D., Liang, Z., Meng, F., Zhang, X., Xue, Y., Maimon, R., and Dowdy, S.F. (2020). Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 582, 550-556.
Gou, L.-T., Lim, D.-H., Ma, W., Aubol, B.E., Hao, Y., Wang, X., Zhao, J., Liang, Z., Shao, C., and Zhang, X. (2020). Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1-catalyzed protamine phosphorylation. Cell 180, 1212-1227. e1214.
Qiu, Z., Zhao, L., Shen, J.Z., Liang, Z., Wu, Q., Yang, K., Min, L., Gimple, R.C., Yang, Q., and Bhargava, S. (2022). Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem CellsTargeting Transcription Machinery Potentiates Immunotherapy. Cancer discovery 12, 502-521.
Zhu, S., Nguyen, A., Pang, J., Zhao, J., Chen, Z.e., Liang, Z., Gu, Y., Huynh, H., Bao, Y., and Lee, S. (2022). Mitochondrial Stress Induces an HRI-eIF2α Pathway Protective for Cardiomyopathy. Circulation 146, 1028-1031.