◆Mechanistic studies in bone & joint diseases and tumors

◆Translational medicine in bone & joint diseases and tumors

1. Fu X, Zhou B, Yan Q, Tao C, Qin L, Wu X, Lin S, Chen S, Lai Y, Zou X, Shao Z, Wang M, Chen D, Jin W, Song Y, Cao H, Zhang G, Xiao G. Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduction and Targeted Therapy. 2020 Dec 26;5(1):297. doi: 10.1038/s41392-020-00328-y.
2. Fu X, Li Y, Huang T, Yu Z, Ma K, Yang M, Liu Q, Pan H, Wang H, Wang J, Guan M. Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate Containing Bone Apatite Formation. Advanced Science. 2018 Jan 28;5(4):1700755. doi: 10.1002/advs.
3. Lei Y, Fu X*, Li P, Lin S, Yan Q, Lai Y, Liu X, Wang Y, Bai X, Liu C, Chen D, Zou X, Cao X, Cao H, Xiao G. LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice. Bone Research. 2020 Oct 13;8:37. doi: 10.1038/s41413-020-00108-y.
4. Qin L, Fu X*, Ma J, Lin M, Zhang P, Wang Y, Yan Q, Tao C, Liu W, Tang B, Chen D, Bai

X, Cao H, Xiao G. Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes. Communications Biology. 2021 Mar 25;4(1):402. doi: 10.1038/s42003-021-01950-4.

5. Li F, Wu X, Fu X*, Liu J, Song W, Xiao GG, Lu A, Zhang G. Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation. International Journal of Biological Sciences. 2022 Jan 9;18(3):1238-1253. doi: 10.7150/ijbs.58784.