（1）研究生理病理条件下，骨骼发育及稳态维持过程中调节成骨细胞、破骨细胞、软骨细胞的形成的机制；

（2）研究局部黏附蛋白（如 Kindlin-2、Migfilin、Pinch1/2）在骨骼发育与稳态中的作用；

（3）糖、脂代谢的调节机制研究；

（4）骨-骨外组织、器官的相互调节研究

医学院临床专业，《生理学》。

指导的博士生、硕士生多次获得国家奖学金。

全长研究论文:

1. Yu S., Franceschi R.T., Luo M., Fan J., Jiang D., Cao H., Kwon T.G., Lai Y., Zhang J., Patrene K., Hankenson K., Roodman G.D., and Xiao G., Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone. PLoS One, 2009. 4(10): p. e7583. PMCID: PMC2762317
2. Cao H.#, Yu S.#, Yao Z., Galson D.L., Jiang Y., Zhang X., Fan J., Lu B., Guan Y., Luo M., Lai Y., Zhu Y., Kurihara N., Patrene K., Roodman G.D., and Xiao G., Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest, 2010. 120(8): p. 2755-66. PMCID: PMC2912190
3. Yang S., Xu H., Yu S., Cao H., Fan J., Ge C., Fransceschi R.T., Dong H.H., and Xiao G., Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem, 2011. 286(21): p. 19149-58. PMID: 21471200.

4. Xiao G.#*, Cheng H.#, Cao H.#, Chen K., Tu Y., Yu S., Jiao H., Yang S., Im H.J., Chen D., Chen J.*, and Wu C.*, Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem, 2012. 287(25): p. 21450-60. PMID: 22556421

6. Teramachi J., Hiruma Y., Ishizuka S., Ishizuka H., Brown J.P., Michou L., Cao H., Galson D.L., Subler M.A., Zhou H., Dempster D.W., Windle J.J., Roodman G.D., and Kurihara N., Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget’s disease. J Bone Miner Res, 2013. 28(6): p. 1489-50. PMID:23426901
7. Zhu K., Jiao H., Li S., Cao H., Galson D.L., Zhao Z., Zhao X., Lai Y., Fan J., Im H.J., Chen D., and Xiao G., ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res, 2013. 28(9): p. 1870-1884. PMID:23649506
8. Cao H., Zhu K., Qiu L., Li S., Niu H., Hao M., Yang S., Zhao Z., Lai Y., Anderson J.L., Fan J., Im H.J., Chen D., Roodman G.D., and Xiao G., Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis. J Biol Chem, 2013. 288(42): p. 30399-410. PMID:24005670

8. Qin T.T., Xu G.C., Qi J.W., Yang G.L., Zhang K., Liu H.L., Xu L.X., Xiang R., Xiao G., Cao H., Wei Y., Zhang Q.Z., and Li L.Y., Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells. J Pathol, 237(3): p. 307-18. PMID: 26096340

9. Wu C. #*, Jiao H.#, Lai Y.#, Zheng W., Chen K., Qu H., Deng W., Song P., Zhu K., Cao H., Galson D.L., Fan J., Im H.J., Liu Y., Chen J., Chen D., and Xiao G.*, Kindlin-2 controls TGF-beta signalling and Sox9 expression to regulate chondrogenesis. Nat Commun, 2015. 6: p. 7531. PMID: 26151572

10. Yang X., Xia R., Yue C., Zhai W., Du W., Yang Q., Cao H., Chen X., Obando D., Zhu Y., Chen X., Chen J.J., Piganelli J., Wipf P., Jiang Y., Xiao G., Wu C., Jiang J., and Lu B., ATF4 Regulates CD4(+) T Cell Immune Responses through Metabolic Reprogramming. Cell Rep, 23(6): p. 1754-1766. PMID:29742431

11. Gao H.#, Guo Y.#, Yan Q.#, Yang W., Li R., Lin S., Bai X., Liu C., Chen D., Cao H.*, and Xiao G.*, Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2. JCI Insight, 2019. 4(13). PMID:31292295

12. Wang Y., Yan Q., Zhao Y., Liu X., Lin S., Zhang P., Ma L., Lai Y., Bai X., Liu C., Wu C., Feng J.Q., Chen D., Cao H.*, and Xiao G.*, Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice. JCI Insight, 2019. 4(22). PMID: 31723057

13. Cao H.#*, Yan Q.#, Wang D.#, Lai Y., Zhou B., Zhang Q., Jin W., Lin S., Lei Y., Ma L., Guo Y., Wang Y., Wang Y., Bai X., Liu C., Feng J.Q., Wu C., Chen D., Cao X., and Xiao G.*, Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice. Bone Research, 2020. 8(1): p. 2. PMID: 31934494.

14. Zhu K., Lai Y., Cao H., Bai X., Liu C., Yan Q., Ma L., Chen D., Kanaporis G., Wang J., Li L., Cheng T., Wang Y., Wu C.*, and Xiao G.*, Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice. Nat Commun, 2020. 11(1): p. 484. PMID: 31980627

15. Chen S., Qin L., Wu X., Fu X., Lin S., Chen D., Xiao G., Shao Z.*, and Cao H.*, Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells. Front Cell Dev Biol, 2020. 8: p. 127. PMID: 32195253

16. Yiming Lei#, Xuekun Fu#, Pengyu Li#, Sixiong Lin, Qinnan Yan, Yumei Lai, Xin Liu, Yishu Wang, Xiaochun Bai, Chuanju Liu, Di Chen, Huiling Cao*, Guozhi Xiao*. LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice. Bone Research, Oct 13, 2020, 8(37). DOI:1038/s41413-020-00108-y.

17. Fu X.#, Zhou B.#, Yan Q.#, Tao C., Qin L., Wu X., Lin S., Chen S., Lai Y., Zou X., Shao Z., Wang M., Chen D., Jin W., Song Y., Cao H.*, Zhang G.*, Xiao G.*­, Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduct Target Ther. Dec 26, 2020, 5(1). DOI: 1038/s41392-020-00328-y.

18. Lei Qin, Xuekun Fu, Jing Ma, Manxia Lin, Peijun Zhang, Yishu Wang, Qingnan Yan, Chu Tao, Wen Liu, Bing Tang, Di Chen, Xiaochun Bai*, Huiling Cao*, Guozhi Xiao*. Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes. Communications Biology, Mar 25, 2021,4(1). DOI: 10.1038/s42003-021-01950-4.

19. Huanqing Gao^#, Yiming Zhong^#, Zhen Ding^#, Sixiong Lin^#, Xiaoting Hou, Wanze Tang, Xiaoqian Zhou, Xuenong Zou, Jie Shao, Fan Yang, Xiaochun Bai, Chuanju Liu, Huiling Cao*, Guozhi Xiao*. Pinch loss ameliorates obesity, glucose intolerance and fatty liver by modulating adipocyte apoptosis in mice. Diabetes, 2021 Nov;70(11):2492-2505. doi: 10.2337/db21-0392

20. Sheng Chen, Xiaohao Wu, Yumei Lai, Di Chen, Xiaochun Bai, Sheng Liu, Yongchao Wu, Huiling Cao*, Zengwu Shao*, Guozhi Xiao*. Kindlin-2 inhibits NLRP3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc. Bone Res., Jan 10, 2022, 10 (5). Doi: 10.1038/s41413-021-00179-5

21. Xiaohao Wu, Yumei Lai, Sheng Chen, Chunlei Zhou, Chu Tao, Xuekun Fu, Jun Li, Jian Huang, Wei Tong, Hongtao Tian, Zengwu Shao, Chuanju Liu, Di Chen, Xiaochun Bai*, Huiling Cao*, Guozhi Xiao*. Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis. Nature Aging, Feb 10, 2022. https://doi.org/10.1038/s43587-021-00165-w

22. Huanqing Gao^1#, Liang Zhou^2#, Yiming Zhong^1#, Zhen Ding^1#, Sixiong Lin^1,3, Xiaoting Hou¹, Xiaoqian Zhou⁴, Jie Shao⁵, Fan Yang⁵, Xuenong Zou³, Huiling Cao^1*, Guozhi Xiao^1*, Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice, Nat Commun, Feb 23, 13:1025 | https://doi.org/10.1038/s41467-022-28692-z.

23. Zhengwei Liu^1#, Wanze Tang^1#, Jiayi Liu^2#, Yingying Han¹, Qinnan Yan¹, Yuechao Dong¹, Xiaomei Liu^1a, Dazhi Yang³, Guixing Ma^1*, Huiling Cao^1*, A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound. Bioact Mater, volume 20, February 2023, Pages 610-626. https://doi.org/10.1016/j.bioactmat.2022.06.008

23. Huanqing Gao^#, Yiming Zhong^#, Liang Zhou^#, Sixiong Lin^#, Xiaoting Hou^#, Zhen Ding, Yan Li, Qing Yao, Huiling Cao, Xuenong Zou, Di Chen, Xiaochun Bai, Guozhi Xiao. Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function. 2023 Jan 9;12:e81792. doi: 10.7554/eLife.81792.

24. Wanze Tang^1#, Zhen Ding^1#, Huanqing Gao^1#, Qinnan Yan^1#, Jingping Liu², Yingying Han¹, Xiaoting Hou¹, Zhengwei Liu¹, Litong Chen¹, Dazhi Yang^1*, Guixing Ma^1*, Huiling Cao^1*, Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting Fas/PPARγ/Fabp4 signaling in mice. Acta Pharmaceutica Sinica B. Jul 07, 2023. https://doi.org/10.1016/j.apsb.2023.07.001.

25. Yuechao DONG^1#, Xiaoting HOU^1#, Yingying HAN¹, Zhen DING¹, Wanze TANG¹, Yangshan CHEN¹, Kaosheng Lv¹, Guixing Ma^1* and Huiling CAO^1*. Kindlin-2 controls angiogenesis through modulating Notch1 signaling.Cell Mol Life Sci. October 2023. 13(10): 3963-3987.  doi: 10.1016/j.apsb.2023.06.016.

26. Xiaoting Hou^1#, Yangshan Chen^1#, Bo Zhou¹, Wanze Tang^1,1a, Zhen Ding¹, Litong Chen¹, Wei Pang¹, Yun Wu², Hongyu Yang², Changzheng Du¹, Dazhi Yang^1a, Guixing Ma¹*, and Huiling Cao¹*. Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice.  Cell Death & Disease, Oct 31, 2023. 14 (10) Pages 709-723, DOI: 10.1038/s41419-023-06235-8.

27. Guixing Ma^1#*, Yingying Han^1#, Wanze Tang^1a, Bo Zhou¹, Litong Chen¹, Zhen Ding¹, Siyuan Cheng¹, Dazhi Yang^1a, Huiling Cao^1*. Endothelial-to-Osteoblast Conversion maintains bone homeostasis. Submitted.

综述及专著章节:

1. Xu H, Cao H, Xiao G. Signaling via PINCH: functions, binding partners and implications in human diseases. Gene. 2016 Aug 30. PMID: 27590440

2. Cao H^#*, Xiao G* (2018): Kindlin Signaling and Bone. 《Encyclopedia of Bone Biology 》(Book chapter) by Dr. Mone Zaidi et al. Available online 29 July 2019. ISBN 978-0-12-814081-9. https://doi.org/10.1016/B978-0-12-801238-3.11176-6

3. 曹惠玲, 杨玮，肖国芝 (2018): 软骨细胞.《骨发育与骨疾病的现代研究》(书号：ISBN 978-7-313-20582-7, Book chapter)

4. Qin Lei, Liu Wen. Cao Huiling*, Xiao Guozhi*. Molecular mechanosensors in osteocytes. Bone Res. 8, 23 (2020, Jun). https://doi.org/10.1038/s41413-020-0099-y.

5. Qin L, He T, Chen S, Cao H*, Xiao G*. Role of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues. Bone Res. 9:44 (2021, Oct) https://doi.org/10.1038/s41413-021-00168-8

6. 陈胜，陈明珏，林嗣雄，曹惠玲，邵增务，肖国芝，线粒体功能障碍与椎间盘退变的研究进展，生物骨科材料与临床研究，

7. Lei Qin, Dazhi Yang, Weihong Yi*, Huiling Cao*, Guozhi Xiao*. Roles of leader and follower cells in the collective cell migration. Mol Biol Cell, Jul 1, 2021, 32(14). DOI: 1091/mbc. E20-10-0681.

8. Sheng Chen, Mingjue Chen, Xiaohao Wu, Sixiong Lin, Chu Tao, Huiling Cao*, Zengwu Shao*, Guozhi Xiao*. Global, regional and national burden of low back pain 1990-2019: a systematic analysis of the Global Burden of Disease Study J Orthop Translat. 2022, Jan.

9. Lei Qin^1#, Nian Liu^1#, Chaolemeng Bao^2#, Dazhi Yang¹, Guixing Ma³, Weihong Yi^1*, Guozhi Xiao^3*, Huiling Cao^3*, Mesenchymal Stem Cells in Fibrotic Diseases – the two sides of the same coin. Acta Pharmacologica Sinica (2022) 0:1–20; https://doi.org/10.1038/s41401-022-00952-0

10. Sorour Sadeghzade, Jingyi Liu, Huiru Wang, Xin Li, Jinrui Cao, Huiling Cao, BinTang, Hongyan Yuan. Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review). Materials Today Bio, Oct 25, 2022. https://doi.org/10.1016/j.mtbio.2022.100473

11. Yuechao DONG^1#, Yangshan CHEN^1#, Guixing MA¹, Huiling CAO^1*. The role of E3 ubiquitin ligases in bone homeostasis and related diseases. Acta Pharmaceutica Sinica B. Jul 06, 2023.  doi: 10.1016/j.apsb.2023.06.016.

专利:

1. 专利号：ZL 2017 1 0180991.X，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗糖尿病的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-04-28，公告（公开）日期：2017-09-01。
2. 专利号：ZL 2017 1 0169753.9，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗肾炎的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-07-31，公告（公开）日期：2017-09-08。
3. 专利号：ZL 2017 1 0170718.9，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗骨性关节炎的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-07-31，公告（公开）日期：2017-09-08。
4. 专利申请号：2021101129689，发明专利，名称：抑制肝细胞中Kindlin-2蛋白表达量的试剂在制备治疗脂肪肝产品中的应用，发明人：肖国芝，曹惠玲，高焕庆，实审阶段，申请日期：2021/1/27。
5. 专利申请号：202210513385.6，发明专利，名称：一种水凝胶喷雾及其制备方法与应用，发明人：曹惠玲，马贵兴，刘正伟，实审，申请日期：2022/05/12。
6. 专利申请号：202210877899X，Kindlin-2作为靶点在治疗骨质疏松及预防癌症骨转移中的应用，发明人：曹惠玲，马贵兴，实审阶段，申请日期：2022/07/25。
7. 专利申请号：202211211629.1，Kindlin-2作为靶点在皮肤创伤修复中的应用，发明人：曹惠玲，马贵兴，实审阶段，申请日期：2022/09/30。