Research Assistant Professor |School of Life Sciences, Department of Neuroscience
My research mainly focuses on the structure and function of synaptic GTPase regulatory proteins and key proteins and protein complexes in inhibitory synaptic postsynaptic density.
Personal Profile
Research
1. Molecular mechanisms of dynamic assembly and phase separation regulation of the inhibitory postsynaptic density protein complex.
2. Mechanisms of Small G proteins and their regulatory factors in synaptic formation and plasticity regulation.
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1. Guanhua Bai, Yu Wang, and Mingjie Zhang*. (2021). Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation. Cell Research 31, 312-325. 10.1038/s41422-020-00433-1.
2. Guanhua Bai#, Hao Li#, Pengwei Qin, Yiqing Guo, Wanfa Yang, Yinmiao Lian, Fei Ye, JianxinChen, Meiling Wu, Ruifeng Huang, Jinsong Li, Youming Lu, Mingjie Zhang*. (2023). Ca2+-induced release of IQSEC2/BRAG1 autoinhibition under physiological and pathological conditions. J. Cell Biol. 222. 10.1083/jcb.202307117.
3. Guanhua Bai#, Ruifeng Huang#, Xinyue Nan#, Mengru Zhuang, Meiling Wu, Yinmiao Lian, Qixu Cai, Honglei Tian, Youming Lu, Hao Li,*, and Mingjie Zhang*. (2025). IQSEC2/BRAG1 May Modulate Postsynaptic Density Assembly Through Ca2+-Induced Phase Separation. J. Cell Biol. 224. 10.1083/jcb.202503076.
4. Guanhua Bai and Mingjie Zhang*. (2022). Inhibitory postsynaptic density from the lens of phase separation. Oxford Open Neuroscience 1. 10.1093/oons/kvac003.
5. Guanhua Bai and Mingjie Zhang*. (2021). Mesophasic Assembly of Inhibitory Postsynaptic Density. Neuroscience bulletin 37, 141-143. 10.1007/s12264-020-00623-2.
6. Guanhua Bai and Mingjie Zhang*. (2021). Clustering acetylcholine receptors in neuromuscular junction by phase-separated Rapsn condensates. Neuron 109, 1907-1909. 10.1016/j.neuron.2021.05.024.
7. Menglong Zeng, Guanhua Bai, and Mingjie Zhang*. (2017). Anchoring high concentrations of SynGAP at postsynaptic densities via liquid-liquid phase separation. Small GTPases 10, 1-9. 10.1080/21541248.2017.1320350.
8. Bowen Jia#, Zeyu Shen#, Shihan Zhu, Jingguo Huang, Zhitao Liao, Shuaizhu Zhao, Hao Li, Shiwen Chen, Yang Xu, Yu Wang, Haitang Peng, Guanhua Bai, Youming Lu, Penger Tong, Wucheng Tao, and Mingjie Zhang*. (2025). Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity. Cell. 10.1016/j.cell.2025.07.047.
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Contact Address
1088 Xueyuan Avenue, Shenzhen 518055, P.R. China
Office Phone
baigh@sustech.edu.cn