Leilei Tian
Education
2003-2008 Jilin University (PhD, Polymer Chemistry and Physics)
1999-2003 Jilin University (Bachelor, Chemical Engineering and Technology)
Research experiences
2015-present: South University of Science and Technology of China Position: associate professor
2014-2015: The University of Chicago Position: Research Fellow
2011-2014: The University of Chicago Position: Post-doctoral Scholar
2009-2010: Clemson University (CU) Position: Post-doctoral Scholar
2008-2009: University of South Carolina (USC) Position: Post-doctoral Scholar
Honours and Awards
Shenzhen Peacock Award, Shenzhen Municipality China
Journal Papers
(30)Li, L. Q.a; Shao, C.a; Liu, T.a; Chao, Z. C.; Chen, H. L.; Xiao, F.; He, H. M.; Wei, Z. X.; Zhu, Y. L.; Wang, H.; Zhang, X. D.; Wen, Y. T.; Yang, B.; He, F.; Tian, L. L.*“NIR-II Emissive Photosensitizer for Hypoxia-Tolerance Photodynamic Theranostics”Adv. Mater. 2020, In Press
(29)Xiao, F.; Chen, Z.; Wei, Z. X.; Tian, L. L.* “Hydrophobic Interaction: A Promising Driving Force for theBiomedical Applications of Nucleic Acids” Adv. Sci. 2020, 2001048.
(28)Chao, Z. C.; Lu, H. W.; Xiao, F.; Shao, C.; Wei, Z. X.; Yu, J. T.; Zhang, X. D.; Li, L.; Tian, L. L.* “Robust and Tumor-Environment-Activated DNA Crosslinker Driving Nanoparticle Accumulation for Enhanced Therapeutics” CCS Chemistry 2020, 2, 349–361.
(27)Xiao, F.; Li, L.; Chao, Z. C.; Shao, C.; Chen, Z.; Wei, Z. X.; Lu, J. X.; Huang, Y. S.; Li, L. Q.; Liu, Q.; Liang, Y. Y.; Tian, L. L.* “Organic Spherical Nucleic Acids Facilitate NIR-II Emitting Dye to Cross Blood-Brain Barrier.” Angew. Chemie 2020, 10.1002/anie.202002312.
(26)Xiao, F.; Wei, Z. X.; Wang, M.; Hoff, A.; Bao, Y.*; Tian, L. L.* “Oligonucleotide-Polymer Conjugates: From Molecular Basics to Practical Application” Topics in Current Chemistry 2020, 378: 24.
(25)Chen, Z.; Lu, J. X.; Xiao, F.; Huang, Y. S.; Zhang, X. J.*; Tian, L. L.* “A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission” Chem. Commun. 2020, 56, 1501-1504.
(24)Wang, M. J.; Han, L.; Zhu, Y. L.; Qi, R.; Tian, L. L.*; He, F.* “Formation of Hierarchical Architectures with Dimensional and Morphological Control in the Self-Assembly of Conjugated Block Copolymers” Small Methods 2020, 4, 1900470.
(23)Shao, C.; Xiao, F.; Guo, H.; Yu, J. T.; Jin, D.; Wu, C. F.; Xi, L.*; Tian, L. L.* “Utilizing Polymer Micelle to Control Dye J-aggregation and Enhance Its Theranostic Capability” iScience 2019, 22, 229–239.
(22)Yu, J. T.; Li, J.; Zhai, S. Y.; Li, L.; Wang, K.; Tang, B.; Meng, H.; Tian, L. L.* “Enzymatically Synthesized DNA Polymer as Co-carrier for Enhanced RNA Interference” ACS Appl. Bio Mater. 2019, 2, 5204−5215.
(21)He, S. H.; Yu, J. T.; Wang, F. F.*; Tian, L. L.* “Well-Optimized Conjugated GO-DNA Nanosystem for Sensitive Ratiometric pH Detection in Live Cells” Langmuir. 2019, 35, 13745−13752.
(20)Li, J.; Li, L.; Yu, J. T.; Zhai, S. Y.; Liu, G. Y.; Tian, L. L.* “Fabrication and Biomedical Applications of “Polymer-Like” Nucleic Acids Enzymatically Produced by Rolling Circle Amplification” ACS Appl. Bio Mater. 2019, 2, 4106−4120.
(19)Mo, D. Z.; Chen, Z.; Han, L.; Lai, H. J.; Chao, P. J.; Zhang, Q. W.*; Tian, L. L.*; He, F.* “Highly stable and bright fluorescent chlorinated polymer dots for cellular imaging” New J. Chem. 2019, 43, 2540-2549.
(18)Li, P.a; Chen, Z.a; Huang, Y. S.; Li, J.; Xiao, F.; Zhai, S. Y.; Wang, Z. M.*; Zhang, X. J.*; Tian, L. L.* “A pH Responsive Fluorescent Probe Based on Dye Modified i-motif Nucleic Acids” Organic & Biomolecular Chemistry. 2018, 16, 9402-9408.
(17)Yuan, X. X.a; Xiao, F.a; Zhao, H. R.; Huang, Y. S.; Shao, C.; Weizmann, Y.*; Tian, L. L.* “High-Yield Method To Fabricate and Functionalize DNA Nanoparticles from the Products of Rolling Circle Amplification” ACS Appl. Bio Mater. 2018, 1, 511−519.
(16)Li, J.; Yu, J. T.; Huang, Y. S.; Zhao, H. R.; Tian, L. L.* “Highly Stable and Multiemissive Silver Nanoclusters Synthesized in Situ in a DNA Hydrogel and Their Application for Hydroxyl Radical Sensing” ACS Appl. Mater. Interfaces. 2018, 10, 26075−26083.
(15)Chen, Z.; Ding, Z. Y.; Zhang, G. Y.; Tian, L. L.*; Zhang, X. J.* “Construction of Thermo-Responsive Elastin-Like Polypeptides (ELPs)-Aggregation-Induced-Emission (AIE) Conjugates for Temperature Sensing” Molecules. 2018, 23, 1725.
(14)Zhao, H. R.; Yuan, X. X.; Yu, J. T.; Huang, Y. S.; Shao, C.; Xiao, F.; Li, L.; Li, Y.; Tian, L. L.* “Magnesium Stabilized Multifunctional DNA Nanoparticles for Tumor-Targeted and pH-Responsive Drug Delivery” ACS Appl. Mater. & Interfaces. 2018, 10, 15418-15427.
(13)Yu, J. T.; He, S. H.; Shao, C.; Zhao, H. R.; Li, J.; Tian, L. L.* “A Common Anchor Facilitated GO-DNA Nano-system for Multiplex MicroRNA Analysis in Live Cells” Nanoscale. 2018, 10, 7067-7076.
(12)Xu, W. L.; Huang, Y. S.; Zhao, H. R.; Li, P.; Liu, G. Y.; Li, J.; Zhu, C. S.; Tian, L. L.* “DNA Hydrogel with Tunable pH-Responsive Properties Produced by Rolling Circle Amplification” Chem. Eur. J. 2017, 23, 18276.
(11)Shao, C.; Liang, J.; He, S. H.; Luan, T. Q.; Yu, J. T.; Zhao, H. R.; Xu, J. Y.; Tian, L. L.* “pH-Responsive Graphene Oxide-DNA Nano-System for Living Cell Imaging and Detection” Anal. Chem. 2017, 89, 5445-5452.
(10)Huang, Y. S.; Xu, W. L.; Liu, G. Y.; Tian, L. L.* “A Pure DNA Hydrogel with Stable Catalytic Ability Produced by One-step Rolling Circle Amplification”, Chem. Commun. 2017, 53, 3038.
(9)Tian, L. L.; Cronin, T. M.; Weizmann, Y.* “Enhancing-effect of Gold Nanoparticles on DNA Strand Displacement Amplifications and Their Application to an Isothermal Telomerase Assay”, Chem. Sci., 2014, 5, 4153 (Front Cover).
(8)Tian, L. L.; Weizmann, Y.* “Real-Time Detection of Telomerase Activity Using the Exponential Isothermal Amplification of Telomere Repeat Assay”, J. Am. Chem. Soc., 2013, 135, 1661.
(7)Tian, L. L.; Sun, Y. P.*; et al. “Graphene Oxides Dispersing and Hosting Graphene Sheets for Unique Nanocomposite Materials”, ACS Nano, 2011, 5, 3052.
(6)Tian, L. L.; Meziani, M. J.; Lu, F. S.; Kong, C. Y.; Cao, L.; Thorne, T. J.; Sun, Y. P.* “Graphene Oxides for Homogeneous Dispersion of Carbon Nanotubes”, ACS Appl. Mater. Inter., 2010, 2, 3217.
(5)Tian, L. L.; Wang, X.; Cao, L.; Meziani, M. J.; Kong, C. Y.; Lu, F. S.; Sun, Y. P.* “Preparation of Bulk C13-Enriched Graphene Materials”, J. Nanomater., 2010, 742167.
(4)Tian, L. L.; Wang, C.; Dawn, S.; Smith, M. D.; Krause, J. A.; Shimizu, L. S.* “Macrocycles with Switchable exo/endo Metal Binding Sites”, J. Am. Chem. Soc., 2009, 131, 17620.
(3)Tian, L. L.; He, F.; Zhang, H. Y.; Xu, H.; Ma, Y. G.*; Shen, J. C. “Thermal Cycloaddition Facilitated by Orthogonal π-π Organization Through Conformational Transfer in a Swivel-Cruciform Oligo(phenylenevinylene)”, Angew. Chem. Int. Ed., 2007, 46, 3245.
(2)Tian, L. L.; Zhang, W.; Yang, B.; Lu, P.; Zhang, M.; Ma, Y. G.*; Shen, J. C. “Zinc (II)-induced Color-tunable Fluorescence Emission in the π-Conjugated Polymers Composed of the Bipyridine Unit: A Way to Get White-light Emission”, J. Phys. Chem. B, 2005, 109, 6944.
(1)Tian, L. L.; Zhang, M.; Lu, P.; Zhang, W.; Yang, B.; Ma, Y. G.* “Fluorescence Quenching Effect of Metal Ions for α, α’-Diamine Containing Conjugated Polymers in Solid Films”, Chinese Sci. Bull., 2004, 49, 246.
Research
1. 国家自然科学基金青年科学基金项目(2016-2018)
“共轭聚合物-DNA自组装体系的制备、光学性质表征、及药物的控制性释放”(主持);
2. 深圳市基础研究项目-自由探索(2015-2017)
“基于DNA 纳米技术制备小干扰RNA 药物输送载体的研究”(主持);
3. 深圳市基础研究项目-学科布局(2016-2019)
“功能性DNA双亲性嵌段聚合物的合成及应用研究”(主持);
4. 深圳市科创委重点实验室项目(2016-2018)
“深圳市有机半导体印刷材料与器件重点实验室”(参与);
5.深圳市科创委基础研究-自由探索项目(2018.03~2020.03)
“生物环境中稳定进行高特异性检测的氧化石墨烯-核酸体系的制备及传感研究”(主持)
Teaching
《物理化学》
《材料化学》