吴长锋

2019-10-30

个人简介

吴长锋，南方科技大学生物医学工程系教授，国家自然科学优秀青年科学基金获得者，中国生物医学工程学会生物光子学专委会委员。主要研究方向为生物光子学、分子探针及成像技术、光电功能高分子材料、生物分析检测与生物传感器。2001-2004年于中国科学院长春光学精密机械与物理研究所凝聚态物理专业攻读博士学位。2005-2008年在美国克莱姆森大学化学系学习并获得博士学位。期间与导师Dr. Jason McNeill合作，在国际上开拓了有机半导体聚合物用于生物光学成像的研究，发展了小尺寸、高亮度的聚合物点（Polymer Dots）光学探针技术。2008-2012年赴华盛顿大学Dr. Daniel Chiu研究组从事博士后研究工作，实现了聚合物点的生物功能化、细胞特异性标记及对活体动物肿瘤的靶向性输送等。当前，主要围绕半导体聚合物的设计合成、光学功能调控及生物医学应用开展研究，期望在超分辨光学成像、可植入智能化生物传感、肿瘤光学治疗等方面取得可以转化的研究成果。迄今在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.、Nano Lett.、ACS Nano、Laser & Photonics Rev.、Opt. Lett.等领域内重要期刊共发表SCI 收录论文100多篇。SCI期刊引用7000多次，当前H因子为41。申请8项PCT，4项获得美国专利授权，部分专利获得产品转化。

实验室主页：http://wulab.bme.sustech.edu.cn/

教育背景
1994-1998 齐鲁工业大学材料科学与工程学院本科
1998-2001 吉林大学材料科学与工程学院硕士
2001-2004 中科院长春光机与物理研究所凝聚态物理博士
2005-2008 美国克莱姆森大学化学系物理化学博士

工作经历
2004-2005 美国克莱姆森大学物理系生物光学博士后
2008-2012 美国华盛顿大学化学系生物分析博士后
2012-2016 吉林大学电子科学与工程学院教授
2016年-至今南方科技大学生物医学工程系教授

项目负责人
2018-2021 国家自然科学基金面上项目 “聚合物量子点植入型葡萄糖传感器及相关微光学系统的研究”
2017-2019 深圳市基础研究（自由探索）项目 “窄带荧光聚合物量子点的设计制备与生物细胞多目标成像研究”
2014-2018 年国家自然科学基金重点项目“开关/闪烁可控聚合物量子点的设计制备及纳米分辨动态光学成像研究”
2012 年国家自然科学优秀青年基金项目“生物医学光子学”

论文

发表论文
1. Zhang, B.; Wang, F.; Zhou, H.; Gao, D.; Yuan, Z.; Wu, C.*; Zhang, X.*, Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy. Angewandet Chemie- International Edition 2019, 58(9), 2744-2748.
2. Chen, H.; Wang, F.; Liu, M.; Qian, M.; Men, X.; Yao, C.; Xi, L.; Qin, W.; Qin, G.*; Wu, C.*, Near-Infrared Broadband Polymer-Dot Modulator with High Optical Nonlinearity for Ultrafast Pulsed Lasers. Laser & Photonics Reviews 2019, 13(2), 1800326.
3. Sun, K.; Yang, Y.; Zhou, H.; Yin, S.; Qin, W.; Yu, J.; Chiu, D.T.; Yuan, Z.; Zhang, X.; Wu, C.*, Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone, ACS Nano 2018, 12 (6), 5176–5184
4. Chen, H.; Fang, X.; Jin, Y.; Hu, X.; Yin, M.; Men, X.; Chen, N.; Fan, C.; Chiu, D. T.; Wan Y.*; Wu, C.*, Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery. Small 2018, 14(21), 1800239.
5. Chang, K.; Liu, Z.; Fang, X.; Chen, H.; Men, X.; Yuan, Y.; Sun, K.; Zhang, X.; Yuan, Z.; Wu, C.*, Enhanced Phototherapy by Nanoparticle-Enzyme via Generation and Photolysis of Hydrogen Peroxide. Nano Letters 2017, 17 (7), 4323-4329.
6. Chen, X.; Liu, Z.; Li R.; Shan, C.; Zeng, Z.; Xue, B.; Yuan, W.; Mo, P.; Xi, P.*; Wu, C.*; Sun, Y.*, Multicolor Super-resolution Fluorescence Microscopy with Blue and Carmine Small Photoblinking Polymer Dots. ACS Nano 2017, 11 (8), 8084-8091.
7. Chen, X.; Li R.; Liu, Z.; Sun, K.; Sun, Z.; Chen, D.; Xu, G.; Xi, P.; Wu, C.*; Sun, Y.*, Small Photoblinking Semiconductor Polymer Dots for Fluorescence Nanoscopy. Advanced Materials 2017, 29 (5), 1604859.
8. Chen, D.; Wu, I. C.; Liu, Z.; Tang, Y.; Chen, H.; Yu, J.; Wu, C.*; Chiu, D. T.*, Semiconducting Polymer Dots with Bright Narrow-Band Emission at 800 nm for Biological Applications. Chemical Science 2017, 8 (5), 3390-3398.
9. Chen, H.; Zhang, J.; Chang, K.; Men, X.; Fang, X.; Zhou, L.; Li, D.; Gao, D.; Yin, S.; Zhang, X.; Yuan, Z.; Wu C.*; Biomaterials. 2017, 144, 42-52.
10. Chen, D.; Li, Q.; Meng, Z.; Guo, L.; Tang, Y.; Liu, Z.; Yin, S.; Qin, W.; Yuan, Z.; Zhang, X.; Wu. C.*, Bright Polymer Dots Tracking Stem Cell Engraftment and Migration to Injured Mouse Liver. Theranostics 2017, 7(7), 1820-1834.
11. Sun, K.; Tang, Y.; Li, Q.; Yin, S.; Qin, W.; Yu, J.; Chiu, D. T.; Liu, Y.; Yuan, Z.; Zhang, X.; Wu, C.*, In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer. ACS Nano 2016, 10 (7), 6769-6781.
12. Wu, C.; Chiu, D. T., Highly Fluorescent Semiconducting Polymer Dots for Biology and Medicine. Angewandet Chemie- International Edition 2013, 52 (11), 3086-3109.
13. Yu, J.; Wu, C.; Zhang, X.; Ye, F.; Gallina, M. E.; Rong, Y.; Wu, I. C.; Sun, W.; Chan, Y. H.; Chiu, D. T., Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross‐Linking and Their Application for Specific Cellular Imaging. Advanced Materials 2012, 24 (26), 3498-3504.
14. Wu, C.; Hansen, S. J.; Hou, Q.; Yu, J.; Zeigler, M.; Jin, Y.; Burnham, D. R.; McNeill, J. D.; Olson, J. M.; Chiu, D. T., Design of Highly Emissive Polymer Dot Bioconjugates for in Vivo Tumor Targeting. Angewandet Chemie- International Edition 2011, 50 (15), 3430-3434.
15. Wu, C.; Schneider, T.; Zeigler, M.; Yu, J.; Schiro, P. G.; Burnham, D. R.; McNeill, J. D.; Chiu, D. T., Bioconjugation of Ultrabright Semiconducting Polymer Dots for Specific Cellular Targeting. Journal of American Chemical Society 2010, 132 (43), 15410-15417.
16. Wu, C.; Jin, Y.; Schneider, T.; Burnham, D. R.; Smith, P. B.; Chiu, D. T., Ultrabright and Bioorthogonal Labeling of Cellular Targets Using Semiconducting Polymer Dots and Click Chemistry. Angewandet Chemie- International Edition 2010, 49 (49), 9436-9440.
17. Wu, C.; Bull, B.; Christensen, K.; McNeill, J., Ratiometric Single‐Nanoparticle Oxygen Sensors for Biological Imaging. Angewandet Chemie- International Edition 2009, 48 (15), 2741-2745.
18. Yu, J.; Wu, C.; Sahu, S. P.; Fernando, L. P.; Szymanski, C.; McNeill, J., Nanoscale 3D tracking with conjugated polymer nanoparticles. Journal of American Chemical Society 2009, 131(51), 18410-18414.
19. Wu, C.; Zheng, Y.; Szymanski, C.; McNeill, J., Energy transfer in a nanoscale multichromophoric system: fluorescent dye-doped conjugated polymer nanoparticles. Journal of Physical Chemistry C 2008, 112(6), 1772-1781.
20. Wu, C.; Bull, B.; Szymanski, C.; Christensen, K.; McNeill, J., Multicolor Conjugated Polymer Dots for Biological Fluorescence Imaging. ACS Nano 2008, 2 (11), 2415-2423.
21. Wu, C.; Szymanski, C.; Cain, Z.; McNeill, J., Conjugated Polymer Dots for Multiphoton Fluorescence Imaging. Journal of American Chemical Society 2007, 129 (43), 12904-12905.
22. Wu, C.; Peng, H.; Jiang, Y.; McNeill, J., Energy transfer mediated fluorescence from blended conjugated polymer nanoparticles. Journal of Physical Chemistry B 2006, 110(29), 14148-14154.
23. Wu, C.; Szymanski, C.; McNeill, J., Preparation and encapsulation of highly fluorescent conjugated polymer nanoparticles. Langmuir 2006, 22(7), 2956-2960.