谢寒寒
2021-04-21
谢寒寒，研究助理教授
谢寒寒博士，主要研究方向为二维纳米材料的制备及其在生物医学领域中的应用。近年来发表SCI论文20余篇，其中以第一作者或共同第一作者身份在Angewandte Chemie International Edition，Small，Biomaterials，ACS Applied Materials & Interfaces等国际权威期刊发表SCI论文9篇。其中2篇论文被选为“封面故事”，1篇论文被选为“卷首”。申请中国发明专利8项，已授权3项，主持或参与国家自然科学基金、中国博士后科学基金等在内的科研项目3项。
谢寒寒博士，主要研究方向为二维纳米材料的制备及其在生物医学领域中的应用。近年来发表SCI论文20余篇，其中以第一作者或共同第一作者身份在Angewandte Chemie International Edition，Small，Biomaterials，ACS Applied Materials & Interfaces等国际权威期刊发表SCI论文9篇。其中2篇论文被选为“封面故事”，1篇论文被选为“卷首”。申请中国发明专利8项，已授权3项，主持或参与国家自然科学基金、中国博士后科学基金等在内的科研项目3项。
工作与学习经历
2021.04.08-至今 南方科技大学 研究助理教授
2018.07-2021.03 深圳市人民医院 博士后
2018.07-2021.03 中国科学院深圳先进技术研究院 客座博士后
2013.09-2018.06 武汉大学 博士
2009.09-2013.06 安庆师范大学 学士
主持/参与科研项目
◆ 黑磷基光响应形状记忆复合材料的构建与医学应用探索，2018-2021，中国博士后科学基金，主持
◆ 基于二维材料光热效应的多功能组织工程支架，国家自然科学基金项目，2017-2019，参与
◆ 磁性温敏微凝胶载药体系的构建及其在膀胱癌热灌注化疗中的应用研究，国家自然科学基金项目，2016-2018，参与
发明专利
◆ 一种显影剂及其制备方法和一种指纹显现方法。专利号：CN107629784B
◆ 一种小尺寸黑磷片及其制备方法。专利号：CN105600760B
◆ 一种聚合物包裹的黑磷及其制备方法与应用。专利号：CN106267201B
研究方向
研究方向主要是构建一种多功能纳米平台，以实现癌症诊断和治疗的一体化。首先构建了一种聚多巴胺修饰的负载有二价铁离子的MnPS3纳米片的新型二维纳米平台。这种基于Fe-MnPS3的二维纳米片显示出优异的芬顿催化活性，能够实现癌症化学动力学治疗(CDT)。同时该材料的光热效应会进一步提升CDT的治疗效率，从而实现PTT/CDT协同的癌症治疗效果。除此之外，该材料还可以实现优异的核磁共振成像以及光声成像，用于成像引导的癌症治疗。该研究将通过构建一种基于二维纳米材料的多功能诊疗平台为癌症治疗提供新的思路。
期刊论文
[1] HH Xie, MQ Liu, BH You, GH Luo, Y Chen, BL Liu, ZY Jiang, PK Chu, JD Shao, and XF Yu. Biodegradable Bi2O2Se Quantum Dots for Photoacoustic Imaging-Guided Cancer Photothermal Therapy. Small, 2020, 16, 1905208.
[2] HH Xie, PH Li, JD Shao, H Huang, Y Chen, ZY Jiang, PK Chu, XF Yu. Electrostatic Self-Assembly of Ti3C2Tx MXene and Gold Nanorods as an Efficient Surface-Enhanced Raman Scattering Platform for Reliable and High-Sensitivity Determination of Organic Pollutants. ACS Sensors, 2019, 4: 2303-2310.
[3] HH Xie#, JD Shao#, YF Ma#, JH Wang, H Huang, N Yang, HY Wang, CS Ruan, YF Luo, QQ Wang, PK Chu, XF Yu. Biodegradable near-infrared-photoresponsive shape memory implants based on black phosphorus nanofillers. Biomaterials, 2018, 164: 11-21.
[4] JD Shao#, HH Xie#, HY Wang, WH Zhou, Q Luo, XF Yu, PK Chu. 2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy. ACS Applied Materials & Interfaces, 2018, 10: 1155-1163.
[5] HH Xie, JD Shao, JH Wang, ZB Sun, XF Yu, QQ Wang. Near-infrared optical performances of two Bi2Se3 nanosheets. RSC Advances, 2017, 7: 50234-50238.
[6] HH Xie, ZB Li, ZB Sun, JD Shao, XF Yu, ZN Guo, JH Wang, QL Xiao, HY Wang, QQ Wang, H Zhang, PK Chu. Metabolizable ultrathin Bi2Se3 nanosheets in imaging-guided photothermal therapy. Small, 2016, 12: 4136-4145.
[7] ZB Sun#, HH Xie#, SY Tang, XF Yu, ZN Guo, JD Shao, H Zhang, H Huang, HY Wang, PK Chu. Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents. Angewandte Chemie International Edition, 2015, 54: 11526-11530.
[8] HH Xie, Q Wen, H Huang, TY Sun, PH Li, Y Li, XF Yu, QQ Wang. Synthesis of bright upconversion submicrocrystals for high-contrast imaging of latent-fingerprints with cyanoacrylate fuming. RSC Advances, 2015, 5: 79525-79531.
[9] HH Xie, M Wu, H Huang, F Qi, L Gu, HY Zhu, XF Yu, QY Gong. Facile Synthesis of Multifunctional Nanocomposites with Magnetic/Upconversion Fluorescence and Singlet Oxygen Generating Capacity. Nanoscience and Nanotechnology Letters, 2015, 7: 375-380.
[10] JD Shao, CS Ruan, HH Xie, PK. Chu, XF Yu. Photochemical Activity of Black Phosphorus for Near‐Infrared Light Controlled In Situ Biomineralization. Advanced Science, 2020, 7, 2000439.
[11] YH Kang, HH Xie, DN Liu, M. Gao, PK Chu, S Ramakrishna, XF Yu. Facile mass production of self-supported two-dimensional transition metal oxides for catalytic applications. Chemical Communications, 2019, 55: 11406-11409.
[12] JD Shao, CS Ruan, HH Xie, ZB Li, HY Wang, PK Chu, XF Yu. Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer. Advanced Science, 2018, 5:1700848.
[13] XZ Wang, JD Shao, MAE Raouf, HH Xie, H Huang, HY Wang, PK Chu, XF Yu, Y Yang, ABM AbdEl-Aal, NHM Mekkawy, RJ Miron, YF Zhang. Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration. Biomaterials, 2018,179: 164. [14] ZH Song, YZ Chang, HH Xie, XF Yu, PK Chu, TF Chen. Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy. NPG Asia Materials, 2017, 9: e439.
[15] ZB Li, JD Shao, Q Luo, XF Yu, HH Xie, HD Fu, SY Tang, HY Wang, GL Han, PK Chu. Cell-Borne 2D Nanomaterials for Efficient Cancer Targeting and Photothermal Therapy. Biomaterials, 2017, 133: 37-48.
[16] HD Fu, ZB Li, HH Xie, ZB Sun, BK Wang, H Huang, GL Han, HY Wang, PK Chu, XF Yu. Different-sized black phosphorus nanosheets with good cytocompatibility and high photothermal performance. RSC Advances, 2017, 7: 14618.
[17] XH Li, RK Liu, HH Xie, Y Zhang, B Lyu, P Wang, JH Wang, Q Fan, Y Ma, SH Tao, S Xiao, XF Yu, YL Gao, J He. Tri-phase all-optical switching and broadband nonlinear optical response in Bi2Se3 nanosheets. Optics Express, 2017, 25: 18346-18354.
[18] YH Xu, HH Xie, GB Jiang, LL Miao, K Wang, SY Tang, XF Yu, H Zhang, QL Bao. Bilayer Bismuth Selenide nanoplatelets based saturable absorber for ultra-short pulse generation. Optics Communications, 2017, 395：55-60.
[19] JD Shao, HH Xie, H Huang, ZB Li, ZB Sun, YH Xu, QL Xiao, XF Yu, YT Zhao, H Zhang, HY Wang, PK Chu. Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy. Nature Communications, 2016, 7: 12967.
[20] Y Yang, J Gao, Z Zhang, S Xiao, HH Xie, ZB Sun, JH Wang, CH Zhou, YW Wang, XY Guo, PK Chu, XF Yu. Black Phosphorus Based Photocathodes in Wideband Bifacial Dye-Sensitized Solar Cells. Advanced Materials, 2016, 28: 8937-8944.
[21] YT Zhao, HY Wang, H Huang, QL Xiao, YH Xu, ZN Guo, HH Xie, JD Shao, ZB Sun, WJ Han, XF Yu, PH Li, PK Chu. Surface Coordination of Black Phosphorus for Excellent Air and Water Stability, Angewandte Chemie International Edition, 2016, 128: 5087-5091.
[22] SY Tang, ZN Guo, JD Shao, XF Yu, HH Xie, Y Li, PH Li, L Zhang, RKY Fu, HY Wang, PK Chu. Drawing-fabrication of multifarious nanoplasmonic platform on PLLA paper for optimized SERS performance. Journal of Raman Spectroscopy, 2016, 14: 687-691.
[23] ZN Guo, H Zhang, SB Lu, ZT Wang, SY Tang, JD Shao, ZB Sun, HH Xie, HY Wang, XF Yu, PK Chu. From Black Phosphorus to Phosphorene: Basic Solvent Exfoliation, Evolution of Raman Scattering, and Applications to Ultrafast Photonics. Advanced Functional Materials, 2015, 25: 6996-7002.
[24] H Huang, JH Wang, WH Jin, PH Li, M Chen, HH Xie, XF Yu, HY Wang, ZG Dai, XH Xiao, PK Chu. Competitive Reaction Pathway for Site-Selective Conjugation of Raman Dyes to Hotspots on Gold Nanorods for Greatly Enhanced SERS Performance. Small, 2014, 10: 4012-4019.
[2] HH Xie, PH Li, JD Shao, H Huang, Y Chen, ZY Jiang, PK Chu, XF Yu. Electrostatic Self-Assembly of Ti3C2Tx MXene and Gold Nanorods as an Efficient Surface-Enhanced Raman Scattering Platform for Reliable and High-Sensitivity Determination of Organic Pollutants. ACS Sensors, 2019, 4: 2303-2310.
[3] HH Xie#, JD Shao#, YF Ma#, JH Wang, H Huang, N Yang, HY Wang, CS Ruan, YF Luo, QQ Wang, PK Chu, XF Yu. Biodegradable near-infrared-photoresponsive shape memory implants based on black phosphorus nanofillers. Biomaterials, 2018, 164: 11-21.
[4] JD Shao#, HH Xie#, HY Wang, WH Zhou, Q Luo, XF Yu, PK Chu. 2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy. ACS Applied Materials & Interfaces, 2018, 10: 1155-1163.
[5] HH Xie, JD Shao, JH Wang, ZB Sun, XF Yu, QQ Wang. Near-infrared optical performances of two Bi2Se3 nanosheets. RSC Advances, 2017, 7: 50234-50238.
[6] HH Xie, ZB Li, ZB Sun, JD Shao, XF Yu, ZN Guo, JH Wang, QL Xiao, HY Wang, QQ Wang, H Zhang, PK Chu. Metabolizable ultrathin Bi2Se3 nanosheets in imaging-guided photothermal therapy. Small, 2016, 12: 4136-4145.
[7] ZB Sun#, HH Xie#, SY Tang, XF Yu, ZN Guo, JD Shao, H Zhang, H Huang, HY Wang, PK Chu. Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents. Angewandte Chemie International Edition, 2015, 54: 11526-11530.
[8] HH Xie, Q Wen, H Huang, TY Sun, PH Li, Y Li, XF Yu, QQ Wang. Synthesis of bright upconversion submicrocrystals for high-contrast imaging of latent-fingerprints with cyanoacrylate fuming. RSC Advances, 2015, 5: 79525-79531.
[9] HH Xie, M Wu, H Huang, F Qi, L Gu, HY Zhu, XF Yu, QY Gong. Facile Synthesis of Multifunctional Nanocomposites with Magnetic/Upconversion Fluorescence and Singlet Oxygen Generating Capacity. Nanoscience and Nanotechnology Letters, 2015, 7: 375-380.
[10] JD Shao, CS Ruan, HH Xie, PK. Chu, XF Yu. Photochemical Activity of Black Phosphorus for Near‐Infrared Light Controlled In Situ Biomineralization. Advanced Science, 2020, 7, 2000439.
[11] YH Kang, HH Xie, DN Liu, M. Gao, PK Chu, S Ramakrishna, XF Yu. Facile mass production of self-supported two-dimensional transition metal oxides for catalytic applications. Chemical Communications, 2019, 55: 11406-11409.
[12] JD Shao, CS Ruan, HH Xie, ZB Li, HY Wang, PK Chu, XF Yu. Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer. Advanced Science, 2018, 5:1700848.
[13] XZ Wang, JD Shao, MAE Raouf, HH Xie, H Huang, HY Wang, PK Chu, XF Yu, Y Yang, ABM AbdEl-Aal, NHM Mekkawy, RJ Miron, YF Zhang. Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration. Biomaterials, 2018,179: 164. [14] ZH Song, YZ Chang, HH Xie, XF Yu, PK Chu, TF Chen. Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy. NPG Asia Materials, 2017, 9: e439.
[15] ZB Li, JD Shao, Q Luo, XF Yu, HH Xie, HD Fu, SY Tang, HY Wang, GL Han, PK Chu. Cell-Borne 2D Nanomaterials for Efficient Cancer Targeting and Photothermal Therapy. Biomaterials, 2017, 133: 37-48.
[16] HD Fu, ZB Li, HH Xie, ZB Sun, BK Wang, H Huang, GL Han, HY Wang, PK Chu, XF Yu. Different-sized black phosphorus nanosheets with good cytocompatibility and high photothermal performance. RSC Advances, 2017, 7: 14618.
[17] XH Li, RK Liu, HH Xie, Y Zhang, B Lyu, P Wang, JH Wang, Q Fan, Y Ma, SH Tao, S Xiao, XF Yu, YL Gao, J He. Tri-phase all-optical switching and broadband nonlinear optical response in Bi2Se3 nanosheets. Optics Express, 2017, 25: 18346-18354.
[18] YH Xu, HH Xie, GB Jiang, LL Miao, K Wang, SY Tang, XF Yu, H Zhang, QL Bao. Bilayer Bismuth Selenide nanoplatelets based saturable absorber for ultra-short pulse generation. Optics Communications, 2017, 395：55-60.
[19] JD Shao, HH Xie, H Huang, ZB Li, ZB Sun, YH Xu, QL Xiao, XF Yu, YT Zhao, H Zhang, HY Wang, PK Chu. Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy. Nature Communications, 2016, 7: 12967.
[20] Y Yang, J Gao, Z Zhang, S Xiao, HH Xie, ZB Sun, JH Wang, CH Zhou, YW Wang, XY Guo, PK Chu, XF Yu. Black Phosphorus Based Photocathodes in Wideband Bifacial Dye-Sensitized Solar Cells. Advanced Materials, 2016, 28: 8937-8944.
[21] YT Zhao, HY Wang, H Huang, QL Xiao, YH Xu, ZN Guo, HH Xie, JD Shao, ZB Sun, WJ Han, XF Yu, PH Li, PK Chu. Surface Coordination of Black Phosphorus for Excellent Air and Water Stability, Angewandte Chemie International Edition, 2016, 128: 5087-5091.
[22] SY Tang, ZN Guo, JD Shao, XF Yu, HH Xie, Y Li, PH Li, L Zhang, RKY Fu, HY Wang, PK Chu. Drawing-fabrication of multifarious nanoplasmonic platform on PLLA paper for optimized SERS performance. Journal of Raman Spectroscopy, 2016, 14: 687-691.
[23] ZN Guo, H Zhang, SB Lu, ZT Wang, SY Tang, JD Shao, ZB Sun, HH Xie, HY Wang, XF Yu, PK Chu. From Black Phosphorus to Phosphorene: Basic Solvent Exfoliation, Evolution of Raman Scattering, and Applications to Ultrafast Photonics. Advanced Functional Materials, 2015, 25: 6996-7002.
[24] H Huang, JH Wang, WH Jin, PH Li, M Chen, HH Xie, XF Yu, HY Wang, ZG Dai, XH Xiao, PK Chu. Competitive Reaction Pathway for Site-Selective Conjugation of Raman Dyes to Hotspots on Gold Nanorods for Greatly Enhanced SERS Performance. Small, 2014, 10: 4012-4019.