Hanhan Xie
2021-04-21
Research Assistant Professor--Hanhan Xie
Dr. Xie is mainly engaged in the preparation of two-dimensional nanomaterials and their applications in the field of biomedicine. In recent years, she has published more than 20 SCI papers, including 9 SCI papers in Angewandte Chemie International Edition, Small, Biomaterials, ACS Applied Materials & Interfaces and other international authoritative journals as the first author or co-first author. Among them, two of the papers are selected as the "cover story", and one paper is selected as the "front volume". Moreover, she has applied for 8 Chinese invention patents, 3 have been authorized. Besides, she has hosted or participated in 3 scientific research projects including the National Natural Science Foundation of China and the China Postdoctoral Science Foundation.
Work&Education Experience
2021.04-Till now Southern University of Science and Technology , Research Assistant Professor
2018.07-2021.03 Shenzhen People’s Hospital, Postdoctoral Fellow
2018.07-2021.03 Shenzhen Institutes ofAdvanced Technology, Chinese Academy of Sciences, Visiting Postdoctoral Fellow
2013.09-2018.06 Wuhan University, Ph. D
2009.09-2013.06 Anqing Normal University, Bachelor
Fund
◆ Construction and medical application exploration of black phosphorous-based light-responsive shape memory composite materials, China Postdoctoral Science Foundation, 2018-2021, chair
◆ Multifunctional tissue engineering scaffold based on the photothermal effect of two-dimensional materials, National Natural Science Foundation of China, 2017-2019, participation
◆ Construction of magnetic thermosensitive microgel drug-carrying system and its application in bladder cancer hyperthermic perfusion chemotherapy, National Natural Science Foundation of China, 2016-2018, participation
◆ Construction and medical application exploration of black phosphorous-based light-responsive shape memory composite materials, China Postdoctoral Science Foundation, 2018-2021, chair
◆ Multifunctional tissue engineering scaffold based on the photothermal effect of two-dimensional materials, National Natural Science Foundation of China, 2017-2019, participation
◆ Construction of magnetic thermosensitive microgel drug-carrying system and its application in bladder cancer hyperthermic perfusion chemotherapy, National Natural Science Foundation of China, 2016-2018, participation
Granted patents
◆ A developer and its preparation method, and a method of fingerprinting displaying. Authorization number: CN107629784B.
◆ Small-sized black phosphorus sheets and its preparation method. Authorization number: CN105600760B.
◆ Polymer-encapsulated black phosphorus and its preparation method and applications. Authorization number: CN106267201B.
◆ A developer and its preparation method, and a method of fingerprinting displaying. Authorization number: CN107629784B.
◆ Small-sized black phosphorus sheets and its preparation method. Authorization number: CN105600760B.
◆ Polymer-encapsulated black phosphorus and its preparation method and applications. Authorization number: CN106267201B.
Research
My research focuses on building a multifunctional nanoplatform to realize the integration of cancer diagnosis and treatment. Here, a novel 2D nanoplatform based on biocompatible MnPS3 nanosheets are fabricated. Such MnPS3-based 2D nanosheets show superior Fenton catalytic activity facilitated by their ultrahigh specific surface area, simultaneously enabling cancer chemodynamic therapy (CDT).The efficiency of CDT could be further remarkably enhanced by its photothermal effect, leading to cancer synergistic PTT/CDT. This research will provide a paradigm for cancer CDT and PTT via a single 2D nanoplatform with desired therapeutic effect.
Publications
[1] HH Xie, MQ Liu, BH You, GH Luo, Y Chen, BL Liu, ZY Jiang, PK Chu, JD Shao, and XF Yu. Biodegradable Bi2O2Se Quantum Dots for Photoacoustic Imaging-Guided Cancer Photothermal Therapy. Small, 2020, 16, 1905208.
[2] HH Xie, PH Li, JD Shao, H Huang, Y Chen, ZY Jiang, PK Chu, XF Yu. Electrostatic Self-Assembly of Ti3C2Tx MXene and Gold Nanorods as an Efficient Surface-Enhanced Raman Scattering Platform for Reliable and High-Sensitivity Determination of Organic Pollutants. ACS Sensors, 2019, 4: 2303-2310.
[3] HH Xie#, JD Shao#, YF Ma#, JH Wang, H Huang, N Yang, HY Wang, CS Ruan, YF Luo, QQ Wang, PK Chu, XF Yu. Biodegradable near-infrared-photoresponsive shape memory implants based on black phosphorus nanofillers. Biomaterials, 2018, 164: 11-21.
[4] JD Shao#, HH Xie#, HY Wang, WH Zhou, Q Luo, XF Yu, PK Chu. 2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy. ACS Applied Materials & Interfaces, 2018, 10: 1155-1163.
[5] HH Xie, JD Shao, JH Wang, ZB Sun, XF Yu, QQ Wang. Near-infrared optical performances of two Bi2Se3 nanosheets. RSC Advances, 2017, 7: 50234-50238.
[6] HH Xie, ZB Li, ZB Sun, JD Shao, XF Yu, ZN Guo, JH Wang, QL Xiao, HY Wang, QQ Wang, H Zhang, PK Chu. Metabolizable ultrathin Bi2Se3 nanosheets in imaging-guided photothermal therapy. Small, 2016, 12: 4136-4145.
[7] ZB Sun#, HH Xie#, SY Tang, XF Yu, ZN Guo, JD Shao, H Zhang, H Huang, HY Wang, PK Chu. Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents. Angewandte Chemie International Edition, 2015, 54: 11526-11530.
[8] HH Xie, Q Wen, H Huang, TY Sun, PH Li, Y Li, XF Yu, QQ Wang. Synthesis of bright upconversion submicrocrystals for high-contrast imaging of latent-fingerprints with cyanoacrylate fuming. RSC Advances, 2015, 5: 79525-79531.
[9] HH Xie, M Wu, H Huang, F Qi, L Gu, HY Zhu, XF Yu, QY Gong. Facile Synthesis of Multifunctional Nanocomposites with Magnetic/Upconversion Fluorescence and Singlet Oxygen Generating Capacity. Nanoscience and Nanotechnology Letters, 2015, 7: 375-380.
[10] JD Shao, CS Ruan, HH Xie, PK. Chu, XF Yu. Photochemical Activity of Black Phosphorus for Near‐Infrared Light Controlled In Situ Biomineralization. Advanced Science, 2020, 7, 2000439.
[11] YH Kang, HH Xie, DN Liu, M. Gao, PK Chu, S Ramakrishna, XF Yu. Facile mass production of self-supported two-dimensional transition metal oxides for catalytic applications. Chemical Communications, 2019, 55: 11406-11409.
[12] JD Shao, CS Ruan, HH Xie, ZB Li, HY Wang, PK Chu, XF Yu. Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer. Advanced Science, 2018, 5:1700848.
[13] XZ Wang, JD Shao, MAE Raouf, HH Xie, H Huang, HY Wang, PK Chu, XF Yu, Y Yang, ABM AbdEl-Aal, NHM Mekkawy, RJ Miron, YF Zhang. Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration. Biomaterials, 2018,179: 164.
[14] ZH Song, YZ Chang, HH Xie, XF Yu, PK Chu, TF Chen. Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy. NPG Asia Materials, 2017, 9: e439.
[15] ZB Li, JD Shao, Q Luo, XF Yu, HH Xie, HD Fu, SY Tang, HY Wang, GL Han, PK Chu. Cell-Borne 2D Nanomaterials for Efficient Cancer Targeting and Photothermal Therapy. Biomaterials, 2017, 133: 37-48.
[16] HD Fu, ZB Li, HH Xie, ZB Sun, BK Wang, H Huang, GL Han, HY Wang, PK Chu, XF Yu. Different-sized black phosphorus nanosheets with good cytocompatibility and high photothermal performance. RSC Advances, 2017, 7: 14618.
[17] XH Li, RK Liu, HH Xie, Y Zhang, B Lyu, P Wang, JH Wang, Q Fan, Y Ma, SH Tao, S Xiao, XF Yu, YL Gao, J He. Tri-phase all-optical switching and broadband nonlinear optical response in Bi2Se3 nanosheets. Optics Express, 2017, 25: 18346-18354.
[18] YH Xu, HH Xie, GB Jiang, LL Miao, K Wang, SY Tang, XF Yu, H Zhang, QL Bao. Bilayer Bismuth Selenide nanoplatelets based saturable absorber for ultra-short pulse generation. Optics Communications, 2017, 395：55-60.
[19] JD Shao, HH Xie, H Huang, ZB Li, ZB Sun, YH Xu, QL Xiao, XF Yu, YT Zhao, H Zhang, HY Wang, PK Chu. Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy. Nature Communications, 2016, 7: 12967.
[20] Y Yang, J Gao, Z Zhang, S Xiao, HH Xie, ZB Sun, JH Wang, CH Zhou, YW Wang, XY Guo, PK Chu, XF Yu. Black Phosphorus Based Photocathodes in Wideband Bifacial Dye-Sensitized Solar Cells. Advanced Materials, 2016, 28: 8937-8944.
[21] YT Zhao, HY Wang, H Huang, QL Xiao, YH Xu, ZN Guo, HH Xie, JD Shao, ZB Sun, WJ Han, XF Yu, PH Li, PK Chu. Surface Coordination of Black Phosphorus for Excellent Air and Water Stability, Angewandte Chemie International Edition, 2016, 128: 5087-5091.
[22] SY Tang, ZN Guo, JD Shao, XF Yu, HH Xie, Y Li, PH Li, L Zhang, RKY Fu, HY Wang, PK Chu. Drawing-fabrication of multifarious nanoplasmonic platform on PLLA paper for optimized SERS performance. Journal of Raman Spectroscopy, 2016, 14: 687-691.
[23] ZN Guo, H Zhang, SB Lu, ZT Wang, SY Tang, JD Shao, ZB Sun, HH Xie, HY Wang, XF Yu, PK Chu. From Black Phosphorus to Phosphorene: Basic Solvent Exfoliation, Evolution of Raman Scattering, and Applications to Ultrafast Photonics. Advanced Functional Materials, 2015, 25: 6996-7002.
[24] H Huang, JH Wang, WH Jin, PH Li, M Chen, HH Xie, XF Yu, HY Wang, ZG Dai, XH Xiao, PK Chu. Competitive Reaction Pathway for Site-Selective Conjugation of Raman Dyes to Hotspots on Gold Nanorods for Greatly Enhanced SERS Performance. Small, 2014, 10: 4012-4019.
[2] HH Xie, PH Li, JD Shao, H Huang, Y Chen, ZY Jiang, PK Chu, XF Yu. Electrostatic Self-Assembly of Ti3C2Tx MXene and Gold Nanorods as an Efficient Surface-Enhanced Raman Scattering Platform for Reliable and High-Sensitivity Determination of Organic Pollutants. ACS Sensors, 2019, 4: 2303-2310.
[3] HH Xie#, JD Shao#, YF Ma#, JH Wang, H Huang, N Yang, HY Wang, CS Ruan, YF Luo, QQ Wang, PK Chu, XF Yu. Biodegradable near-infrared-photoresponsive shape memory implants based on black phosphorus nanofillers. Biomaterials, 2018, 164: 11-21.
[4] JD Shao#, HH Xie#, HY Wang, WH Zhou, Q Luo, XF Yu, PK Chu. 2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy. ACS Applied Materials & Interfaces, 2018, 10: 1155-1163.
[5] HH Xie, JD Shao, JH Wang, ZB Sun, XF Yu, QQ Wang. Near-infrared optical performances of two Bi2Se3 nanosheets. RSC Advances, 2017, 7: 50234-50238.
[6] HH Xie, ZB Li, ZB Sun, JD Shao, XF Yu, ZN Guo, JH Wang, QL Xiao, HY Wang, QQ Wang, H Zhang, PK Chu. Metabolizable ultrathin Bi2Se3 nanosheets in imaging-guided photothermal therapy. Small, 2016, 12: 4136-4145.
[7] ZB Sun#, HH Xie#, SY Tang, XF Yu, ZN Guo, JD Shao, H Zhang, H Huang, HY Wang, PK Chu. Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents. Angewandte Chemie International Edition, 2015, 54: 11526-11530.
[8] HH Xie, Q Wen, H Huang, TY Sun, PH Li, Y Li, XF Yu, QQ Wang. Synthesis of bright upconversion submicrocrystals for high-contrast imaging of latent-fingerprints with cyanoacrylate fuming. RSC Advances, 2015, 5: 79525-79531.
[9] HH Xie, M Wu, H Huang, F Qi, L Gu, HY Zhu, XF Yu, QY Gong. Facile Synthesis of Multifunctional Nanocomposites with Magnetic/Upconversion Fluorescence and Singlet Oxygen Generating Capacity. Nanoscience and Nanotechnology Letters, 2015, 7: 375-380.
[10] JD Shao, CS Ruan, HH Xie, PK. Chu, XF Yu. Photochemical Activity of Black Phosphorus for Near‐Infrared Light Controlled In Situ Biomineralization. Advanced Science, 2020, 7, 2000439.
[11] YH Kang, HH Xie, DN Liu, M. Gao, PK Chu, S Ramakrishna, XF Yu. Facile mass production of self-supported two-dimensional transition metal oxides for catalytic applications. Chemical Communications, 2019, 55: 11406-11409.
[12] JD Shao, CS Ruan, HH Xie, ZB Li, HY Wang, PK Chu, XF Yu. Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer. Advanced Science, 2018, 5:1700848.
[13] XZ Wang, JD Shao, MAE Raouf, HH Xie, H Huang, HY Wang, PK Chu, XF Yu, Y Yang, ABM AbdEl-Aal, NHM Mekkawy, RJ Miron, YF Zhang. Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration. Biomaterials, 2018,179: 164.
[14] ZH Song, YZ Chang, HH Xie, XF Yu, PK Chu, TF Chen. Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy. NPG Asia Materials, 2017, 9: e439.
[15] ZB Li, JD Shao, Q Luo, XF Yu, HH Xie, HD Fu, SY Tang, HY Wang, GL Han, PK Chu. Cell-Borne 2D Nanomaterials for Efficient Cancer Targeting and Photothermal Therapy. Biomaterials, 2017, 133: 37-48.
[16] HD Fu, ZB Li, HH Xie, ZB Sun, BK Wang, H Huang, GL Han, HY Wang, PK Chu, XF Yu. Different-sized black phosphorus nanosheets with good cytocompatibility and high photothermal performance. RSC Advances, 2017, 7: 14618.
[17] XH Li, RK Liu, HH Xie, Y Zhang, B Lyu, P Wang, JH Wang, Q Fan, Y Ma, SH Tao, S Xiao, XF Yu, YL Gao, J He. Tri-phase all-optical switching and broadband nonlinear optical response in Bi2Se3 nanosheets. Optics Express, 2017, 25: 18346-18354.
[18] YH Xu, HH Xie, GB Jiang, LL Miao, K Wang, SY Tang, XF Yu, H Zhang, QL Bao. Bilayer Bismuth Selenide nanoplatelets based saturable absorber for ultra-short pulse generation. Optics Communications, 2017, 395：55-60.
[19] JD Shao, HH Xie, H Huang, ZB Li, ZB Sun, YH Xu, QL Xiao, XF Yu, YT Zhao, H Zhang, HY Wang, PK Chu. Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy. Nature Communications, 2016, 7: 12967.
[20] Y Yang, J Gao, Z Zhang, S Xiao, HH Xie, ZB Sun, JH Wang, CH Zhou, YW Wang, XY Guo, PK Chu, XF Yu. Black Phosphorus Based Photocathodes in Wideband Bifacial Dye-Sensitized Solar Cells. Advanced Materials, 2016, 28: 8937-8944.
[21] YT Zhao, HY Wang, H Huang, QL Xiao, YH Xu, ZN Guo, HH Xie, JD Shao, ZB Sun, WJ Han, XF Yu, PH Li, PK Chu. Surface Coordination of Black Phosphorus for Excellent Air and Water Stability, Angewandte Chemie International Edition, 2016, 128: 5087-5091.
[22] SY Tang, ZN Guo, JD Shao, XF Yu, HH Xie, Y Li, PH Li, L Zhang, RKY Fu, HY Wang, PK Chu. Drawing-fabrication of multifarious nanoplasmonic platform on PLLA paper for optimized SERS performance. Journal of Raman Spectroscopy, 2016, 14: 687-691.
[23] ZN Guo, H Zhang, SB Lu, ZT Wang, SY Tang, JD Shao, ZB Sun, HH Xie, HY Wang, XF Yu, PK Chu. From Black Phosphorus to Phosphorene: Basic Solvent Exfoliation, Evolution of Raman Scattering, and Applications to Ultrafast Photonics. Advanced Functional Materials, 2015, 25: 6996-7002.
[24] H Huang, JH Wang, WH Jin, PH Li, M Chen, HH Xie, XF Yu, HY Wang, ZG Dai, XH Xiao, PK Chu. Competitive Reaction Pathway for Site-Selective Conjugation of Raman Dyes to Hotspots on Gold Nanorods for Greatly Enhanced SERS Performance. Small, 2014, 10: 4012-4019.