Li Kai Angelw, Southern University of science and technology: Receptor Engineering to Optimize Reactive Oxygen Species Production and Promote Phenotypic Reprogramming of Macrophages
Anti tumor macrophage (PDM1) is an effective strategy to overcome tumor related immune suppression. However, the relationship between reactive oxygen species (ROS) produced by type I and type II mechanisms and the polarization effect of macrophages is still unclear. Li Kai, a researcher of Southern University of science and technology, has designed and synthesized three kinds of donor receptor photosensitizers with aggregation enhancing ROS production. Their ROS production efficiency can be regulated by changing the receptors, thus producing different abilities to activate macrophages.
The main points of this paper are as follows
(1) It was found that extracellular ROS produced by type I mechanism was mainly responsible for reprogramming macrophages from M2 type to M1 type. In vivo experiments further proved that aiegen photosensitizer can trigger photodynamic immunotherapy and effectively inhibit the growth of tumor in mice, but the therapeutic effect of aiegen photosensitizer in the mouse model of macrophage reduction is obviously poor.
(2) In conclusion, this study provides a reference guide for the design of photosensitizer molecules that can activate macrophages, and provides new insights for understanding the working principle of macrophage activation in photodynamic immunotherapy.
Guang Yang. et al. Acceptor Engineering for Optimized ROS Generation Facilitates Reprogramming Macrophages to M1 Phenotype in Photodynamic Immunotherapy. Angewandte Chemie International Edition. 2020