The synthesis of natural products that feature good biologically active applications have been the source of significant research, but their often congested organic structures make their chemical synthesis extremely challenging. A group of researchers in Shenzhen has been working on this challenge for many years, and has found a number of unique solutions. 2019 […]
The genus Daphniphyllum comprises evergreen trees and shrubs native to the Asia-Pacific region, which have long been used in traditional Chinese medicine. Various Daphniphyllum alkaloids have exhibited diverse bioactivities, such as antitubulin polymerization, anticarcinogenic, anti-HIV, vasorelaxant, and cytotoxic activities. More than 330 Daphniphyllum alkaloids have been isolated from the genus Daphniphyllum to date, comprising a structurally fascinating and diverse natural product family. From a […]
The Daphniphyllum alkaloids are a structurally fascinating and remarkably diverse family of natural products. General strategies for the chemical synthesis of their challenging architectures are highly desirable for efficiently accessing these intriguing alkaloids and addressing their pharmaceutical potential. Recently, Associate Professor Xu Jing from the Department of Chemistry and the Shenzhen Grubbs Institute at Southern University of […]
Nature Reviews – Chemistry is a top review journal for chemistry, from the Nature group of journals. Associate Professor Xu Jing from the Department of Chemistry of Southern University of Science and Technology (SUSTech) was recently invited to publish an article called “Innovation in protecting-group-free natural product synthesis.” This reflects SUSTech’s continuous advances in complex […]
Atropurpuran is from a class of natural chemical compounds that are thought to relieve pain, particularly in folk medicine in the northern hemisphere. A new study from Southern University of Science and Technology (SUSTech) has found a more efficient way to synthesize this unique compound, thereby reducing the reliance on previous methods that were more […]
Our group has accomplished a remarkable total synthesis of a three-decade-unsolved synthetic challenge, astellatol. This research, entitled with Total Synthesis of Astellatol, was published online as VIP (Very Important Paper) in Angew. Chem. Int. Ed on the Chinese New Year’s Eve. In this paper, a nearly-30-year-old unanswered synthetic puzzle, astellatol, has been solved in […]
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