• Journal Papers


Protecting‐Group‐Free Total Synthesis and Biological Investigation of Cabucine Oxindole A. S. Xie,+ C. Ning,+ Q. Yu,+ J. Hou, J. Xu,* Chin. J. Chem. 202139, 137. (+ equal contribution)

Invited manuscript for celebrating the 10th anniversary of the Department of Chemistry of SUSTech




Total Synthesis of Daphniphyllum Alkaloids: From Bicycles to Diversified Caged Structures. L.-D. Guo,+  Y. Chen,+  J. Xu,* Acc. Chem. Res. 2020532726–2737. (+ equal contribution) 





Asymmetric Total Synthesis of Yuzurimine-type Daphniphyllum Alkaloid (+)-Caldaphnidine J. L.-D. Guo, Y. Zhang,+ J. Hu,+ C. Ning, H. Fu, Y. Chen, J. Xu,* Nat. Commun. 202011, 3538. (+ equal contribution)




Enantioselective Total Synthesis of (−)-Caldaphnidine O via a Radical Cyclization Cascade. L.-D. Guo, J. Hu,+ Y. Zhang,+  W. Tu, Y. Zhang, F, Pu, J. Xu,* J. Am. Chem. Soc. 2019141, 13043−13048. (+ equal contribution)




Total Synthesis of Dapholdhamine B and Dapholdhamine B Lactone. L.-D. Guo, J. Hou,+ W. Tu,+ Y. Zhang, Y. Zhang, L. Chen, J. Xu,* J. Am. Chem. Soc. 2019141, 11713−11720. (+ equal contribution)




Synthesis of the Core Structure of Daphnimacropodines.  Y. Chen, J. Hu, L.-D. Guo, P. Tian, T. Xu, J. Xu*, Org. Lett. 201921, 4309−4312.




Asymmetric Total Synthesis of (+)-Astellatol and (−)-Astellatene. N. Zhao, S. Xie, P. Tian, R. Tong, C. Ning,* J. Xu,* Org. Chem. Front. 20196, 2014−2022.




A Concise Total Synthesis of (–)-Himalensine A. Y. Chen, J. Hu, L.-D. Guo, W. Zhong, C. Ning, J. Xu,Angew. Chem. Int. Ed. 201958, 7390−7394.




13-Step Total Synthesis of Atropurpuran. S. Xie,+ G. Chen,+ H. Yan,+ J. Hou, Y. He, T. Zhao, J. Xu,* J. Am. Chem. Soc. 2019141, 3435−3439. (+ equal contribution)

Featured as Top 10 most read articles from JACS, Feb. 2019




Innovation in Protecting-Group-Free Natural Product Synthesis. C. Hui, F. Chen,+ F. Pu,+ J. Xu,* Nature Reviews Chemistry 20193, 85−107. (+ equal contribution)




Gallic acid disruption of Aβ1–42 aggregation rescues cognitive decline of APP/PS1 double transgenic mouse. M. Yu, X. Chen, J. Liu, Q. Ma, Z. Zhuo, H. Chen, L. Zhou, S. Yang, L. Zheng, C. Ning, J. Xu, T. Gao, S.-T. Hou,* Neurobiol. Dis. 2019124, 67−80. 





Total Synthesis of Sesterterpenoids. Y. Chen, J. Zhao,* S.-P. Li, J. Xu,* Nat. Prod. Rep. 201936, 263−288.  (Invited manuscript) 




Efficient Synthesis of the AC Ring System of Daphnilactone B. Y. Zhang, L.-D. Guo,* J. Xu,*  Chin. J. Org. Chem. 201939, 1079−1084.




Stereoselective Synthesis of the ABC Ring System of Aspterpenacids. S. Xie, P. Ren, J. Hou, C. Ning,* J. Xu,*  J. Org. Chem. 2018, 83, 14152−14157.




 Total Synthesis of Astellatol: A Three-Decade Synthetic Puzzle. N. Zhao, S. Xie, H. Huang, J. Xu,* Synlett 201815, 1933−1936. (Invited Synpacts)




Total Synthesis of Astellatol. N. Zhao,+ S. Yin,+ S. Xie, H. Yan, P. Ren, G. Chen, F. Chen, J. Xu,* Angew. Chem. Int. Ed. 201857, 3386−3390. (+ equal contribution)
Featured as No. 1 most accessed articles from Angewandte Chemie, Feb. 2018
Featured as the VIP and Back Cover Article for Angew. Chem. Int. Ed. 2018, 57, Issue 13

Highlighted in SynfactsChemViews MagazineOrganic Chemistry Portal and SUSTech News.


  25.  Triptolide Derivatives as Potential Multifunctional Anti-Alzheimer Agents: Synthesis and Structure-Activity Relationship Studies. C. Ning, L. Mo, X. Chen, W. Tu, J. Wu,* S.-T. Hou,* J. Xu,* Bioorg. Med. Chem. Lett. 201828, 689−693.




Nine-Step Total Synthesis of (–)-Strychnofoline. Q. Yu, P. Guo, J. Jian, Y. Chen, J. Xu,* Chem. Comm. 201854, 1125−1128.


  23.    Enantioselective Synthesis of (−)-Phaseic Acid. W. Tu, C. Ning, J. Xu,* Org. Chem. Front. 20185, 29−31. (invited manuscript)



  22.   Metal Catalyzed Asymmetric Michael Addition in Natural Product Synthesis. S. Hui, F. Pu, J. Xu,* Chem. Eur. J. 201623, 4023−4036.



  21.  Concise Synthesis of Astellatol Core Skeleton. N. Zhao, S. Xie, G. Chen. J. Xu,* Chem. Eur. J. 201622, 12634−12636.



  20.  Palladium-Catalyzed sp3 C–H Oxidation Using Oxime as Directing Group—Applications in Total Synthesis. C. Hui, J. Xu,* Tetrahedron Lett. 201657, 2692−2696. (invited manuscript)




Before SUSTech:

19. Synthetic strategies toward the decalin motif of maklamicin and related spirotetronates, M. H. Lacoske, J. Xu, N. Mansour, C. Gao, E. A. Theodorakis*, Org. Chem. Front. 20152, 388. (invited manuscript)

18. Synthesis of mulinane diterpenoids, K. P. Reber, J. Xu, C. A. Guerrero*, J. Org. Chem. 201580, 2397.

17. Proximity enabled protein crosslinking (PEPC) via genetically en-coding haloalkane unnatural amino acids, Z. Xiang, V. Lacey, H. Ren, J. Xu, D. Burban, P. Jennings, L. Wang*, Angew. Chem. Int. Ed. 201453, 2190.

16. Fusarisetins: structure-function studies on a novel class of cell migration inhibitors, E. J.E. Caro-Diaz, A. Aung, J. Xu, S. Varghese, E. A. Theodorakis*, Org. Chem. Front. 2014, 1, 135-139. (invited manuscript)

15. Neurotrophic natural products: chemistry and biology, J. Xu, M. H. Lacoske and E. A. Theodorakis*, Angew. Chem. Int. Ed. 2014, 53, 956. (invited manuscript) 
      Featured as the Cover Article for Angew. Chem. Int. Ed. 2014, 53, Issue 4.

14. A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia Xanthones, K. M. Elbel, G. Guizzunti, M. TheodorakiJ. Xu, A. Batova, M. Dakanali and E. A. Theodorakis*, Org. Biomol. Chem. 201311, 3341.

13. Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies, L. Trzoss, J. Xu*, M. H. Lacoske, W. C. Mobley and E. A. Theodorakis*, Chem. Eur. J. 201319, 6398.

12. Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation, L. Trzoss, J. Xu, M. H. Lacoske, and E. A. Theodorakis*, Beilstein J. Org. Chem. 20139, 1135. (invited manuscript)

11. Fusarisetin A: Scalable total synthesis and related studies, J. Xu, E. J. E. Caro-Diaz, M. H. Lacoske, C.-I. Hung, C. Jamora* and E. A. Theodorakis*, Chem. Sci. 2012, 3, 3378. 
      Featured as Top 10 most read Chem. Sci. paper, October 2012;
      Highlighted on the Organic Chemistry Portal, August 2013;

10. Nature-inspired total synthesis of (–)-fusarisetin A, J. Xu, E. J. E. Caro-Diaz, L. Trzoss, and E. A. Theodorakis*, J. Am. Chem. Soc. 2012, 134, 5072. 
      Featured as No. 1 most read JACS paper, 2012-2013; 
      Highlighted on the C&EN news, 2012Vol. 90, Issue 26, page 10.

9. Formal synthesis of (–)-englerin A and discovery of truncated englerin analogues with cytotoxicity against leukemia cells, J. Xu, E. J. E. Caro-Diaz, A. Batova and E. A. Theodorakis*, Chem. Asian J. 2012, 7, 1052.

8. Enantioselective synthesis of (–)-jiadifenin, a potent neurotrophic modulator, L. Trzoss, J. Xu*, M. H. Lacoske, W. C. Mobley, E. A. Theodorakis*, Org. Lett. 201113, 4554.

7. Enantioselective total synthesis of (–)-jiadifenolide, J. Xu, L. Trzoss, W. K. Chang and E. A. Theodorakis*, Angew. Chem. Int. Ed. 201150, 3672. 
    Featured as Top 25 most accessed articles from Angewandte Chemie, October 2010 – January 2012;
    Highlighted on the Organic Chemistry Portal, February 2012

6. Synthesis of (–)-callicarpenal, a potent arthropod-repellent, T. T. Ling, J. Xu, R. Smith, A. Ali, C. L. Cantrell and E. A. Theodorakis*, Tetrahedron 201167, 3023.

5. Enantioselective formal synthesis of (–)-englerin A via a Rh-catalyzed [4+3] cycloaddition reaction, J. Xu, E. J. E. Caro-Diaz and E. A. Theodorakis*, Org. Lett. 201012, 3708.
    Highlighted on the Organic Chemistry Portal, April 2011

4. Serotonin derivatives as a new class of non-ATP competitive receptor tyrosine kinase inhibitors, A. Büttner, T. Cottin, J. Xu, L. Tzagkaroulaki, A. Giannis*, Bioorg. Med. Chem. 201018, 3387.

3. Development and biological evaluation of a novel Aurora A kinase inhibitor, T. Sardon, T. Cottin, J. Xu, A. Giannis*, I. Vernos*, ChemBioChem 200910, 464.

2. Synthesis of 5-amino-2-(N,N-dibenzylamino)-3-hydroxy-1,6-diphenylhexane, R.-H. Zhang*, P. Zhao, J. Xu, Z.-L. Zhu, Chin. J. Med. Chem. 200414, 357.

1. Synthesis process of cyclohexyl methyl dichlorosilane, R.-H. Zhang*, J. Xu, Y.-J. Li, Z.-L. Zhu, Y.-M. Ni, Chin. J. Syn. Chem. 200311, 421.







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