• Journal Papers

Selected Publication:

(*Co-first Author,#Corresponding Author, for complete publication list, please see

  • Liu Y, Li L, Yu C, Zeng F, Niu F#,  Wei Z#. Cargo Recognition Mechanisms of Yeast Myo2 Revealed by AlphaFold2-Powered Protein Complex Prediction. Biomolecules, 12(8).(2022)
  • Xu Y, Guo C, Pan W, Zhao C, Ding Y, Xie X, Wei Z#, Sun Y#, Yu C#. Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A. JBC, 297(2):100958 (2021).
  • Liang M, Jin G, Xie X, Zhang W, Li K, Niu F, Yu C#, Wei Z#.Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep. 34:108901. (2021)
  • Yang H, Lin L, Sun K, Zhang T, Chen W, Li L, Xie Y, Wu C, Wei Z, Yu C.Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics. eLife. 10.(2021)
  • Niu F*, Sun K*, Wei W, Yu C#, Wei Z#. F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis. Sci Adv. 6:eabb1307 (2020)
  • Xiao Q, Wang L, Supekar S, Shen T, Liu H, Ye F, Huang J, Fan H#, Wei Z#, Zhang C#. Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride. Nat Commun. 11:5430 (2020)
  • Xie X, Luo L, Liang M, Zhang W, Zhang T, Yu C, Wei Z#. Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity. Nat Commun. 11:169 (2020)
  • Tang K#, Li Y, Yu C, Wei Z#. Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2. J Biol Chem294:5896-5906. (2019)
  • Liang M*, Xie X*, Pan J, Jin G, Yu C#, Wei Z#. Structural basis of the target-binding mode of the G protein-coupled receptor kinase-interacting protein in the regulation of focal adhesion dynamics. J Biol Chem294:5827-5839. (2019)
  • Wang L, Yao D, Deepak RNVK, Liu H, Xiao Q, Fan H, Gong W, Wei Z#, Zhang C#. Structures of the human PGD2 receptor CRTH2 reveal novel mechanisms for ligand recognition. Mol Cell. 72:48-59.e4. (2018)
  • Pan W*, Sun K*, Tang K*, Xiao Q, Ma C, Yu C, Wei Z#. Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion. J Biol Chem. 293:1944-1956. (2018)
  • Li H*, Deng Y*, Sun K, Yang H, Liu J, Wang M, Zhang Z, Lin J, Wu C#, Wei Z#, Yu C#. Structural basis of kindlin-mediated integrin recognition and activation. Proc Natl Acad Sci U S A. 114(35):9349-9354. (2017)
  •  Wei Z*, Xu Z*, Liu X, Lo WS, Ye F, Lau CF, Wang F, Zhou JJ, Nangle LA, Yang XL, Zhang M, Schimmel P#. Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase. Nucleic Acids Res. Feb 18;44(3):1247-55(2016)
  • Zhao H, Sheng G, Wang J, Wang M, Bunkoczi G, Gong W, Wei Z#, Wang Y#. Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli. Nature. 515:147-150 (2014)
  • Li Y*, Wei Z*, Yan Y, Wan Q, Du Q, Zhang M#. Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex. Proc Natl Acad Sci USA. 111:17444-17449. (2014)
  • Wang C*, Wei Z*, Chen K, Ye F, Yu C, Bennett V, Zhang M#. Structural basis of diverse membrane target recognitions by ankyrins. Elife. 3. (2014)
  • Wei Z#, Liu X, Yu C, Zhang M#. Structural basis of cargo recognitions for class V myosins. Proc Natl Acad Sci USA.110: 11314-11319. (2013)
  • Wang C, Yu C, Ye F, Wei Z#, Zhang M#. Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function. Proc Natl Acad Sci USA. 109:4822-4827 (2012)
  • Wei Z*, Zheng S*, Spangler SA, Yu C, Hoogenraad C, Zhang M#. Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures. Mol Cell. 43:586-598 (2011)
  • Wei Z*, Yan J*, Lu Q, Pan L, Zhang M#. Cargo Recognition Mechanism of Myosin X Revealed by the Structure of its Tail MyTH4-FERM Tandem in Complex with the DCC P3 Domain. Proc Natl Acad Sci USA. 108:3572-3577 (2011)
  • Wu L*, Pan L*, Wei Z, Zhang M#. Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. Science. 331:757-60 (2011)
  • Liu W*, Wen W*, Wei Z, Yu J, Ye F, Liu C, Hardie RC, Zhang M#. The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Cell. 145:1088-1101 (2011)
  • Cheng Z, Biechele T, Wei Z, Morrone S, Moon R, Wang L, Xu W#. Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat Struct Mol Biol. 18:1204-1210 (2011)
  • Wang R*, Wei Z*, Jin H, Wu H, Yu C, Wen W, Chan LN, Wen Z, Zhang M#. Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor. Mol Cell. 27: 692-703 (2009)
  • Yu C*, Feng W*, Wei Z, Miyanoiri Y, Zhao Y, Zhang M#. Myosin VI Undergoes Cargo-Mediated Dimerization. Cell. 138: 537-548 (2009)

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